Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| COLO 858 | Vemurafenib | PF562271 | 1.000 | 0.000 | uM | 72 | hr | 3 | 1510 | 705 | 0.1452 | 0.1377 | 0.4669 | 0.4424 |
| COLO 858 | Vemurafenib | PF562271 | 1.000 | 0.000 | uM | 72 | hr | 1 | 1250 | 489 | 0.1372 | 0.1377 | 0.3912 | 0.4424 |
| COLO 858 | Vemurafenib | (+)-JQ1 | 0.000 | 1.000 | uM | 72 | hr | 2 | 904 | 415 | 0.1484 | 0.1822 | 0.4591 | 0.4375 |
| COLO 858 | Vemurafenib | (+)-JQ1 | 0.000 | 1.000 | uM | 72 | hr | 3 | 1095 | 559 | 0.1627 | 0.1822 | 0.5105 | 0.4375 |
| COLO 858 | Vemurafenib | (+)-JQ1 | 0.000 | 1.000 | uM | 72 | hr | 1 | 1181 | 405 | 0.2356 | 0.1822 | 0.3429 | 0.4375 |
| A-375 | Vemurafenib | (+)-JQ1 | 1.000 | 1.000 | uM | 72 | hr | 1 | 1979 | 884 | 0.0774 | 0.0702 | 0.4467 | 0.4350 |
| A-375 | Vemurafenib | (+)-JQ1 | 1.000 | 1.000 | uM | 72 | hr | 2 | 1849 | 762 | 0.0769 | 0.0702 | 0.4121 | 0.4350 |
| A-375 | Vemurafenib | (+)-JQ1 | 1.000 | 1.000 | uM | 72 | hr | 3 | 1434 | 640 | 0.0562 | 0.0702 | 0.4463 | 0.4350 |
| WM-115 | Vemurafenib | (+)-JQ1 | 0.100 | 1.000 | uM | 72 | hr | 3 | 1722 | 787 | 0.2869 | 0.3130 | 0.4570 | 0.4335 |
| WM-115 | Vemurafenib | (+)-JQ1 | 0.100 | 1.000 | uM | 72 | hr | 2 | 1817 | 782 | 0.3175 | 0.3130 | 0.4304 | 0.4335 |
| WM-115 | Vemurafenib | (+)-JQ1 | 0.100 | 1.000 | uM | 72 | hr | 1 | 1859 | 768 | 0.3347 | 0.3130 | 0.4131 | 0.4335 |
| COLO 858 | Vemurafenib | I-BET | 1.000 | 0.000 | uM | 72 | hr | 1 | 916 | 420 | 0.1516 | 0.1880 | 0.4585 | 0.4335 |
| COLO 858 | Vemurafenib | I-BET | 1.000 | 0.000 | uM | 72 | hr | 2 | 975 | 407 | 0.1736 | 0.1880 | 0.4174 | 0.4335 |
| COLO 858 | Vemurafenib | I-BET | 1.000 | 0.000 | uM | 72 | hr | 3 | 1357 | 576 | 0.2388 | 0.1880 | 0.4245 | 0.4335 |
| COLO 858 | Vemurafenib | Defactinib | 0.000 | 3.160 | uM | 72 | hr | 1 | 1609 | 714 | 0.1063 | 0.1023 | 0.4438 | 0.4297 |
| COLO 858 | Vemurafenib | Defactinib | 0.000 | 3.160 | uM | 72 | hr | 3 | 1265 | 531 | 0.0871 | 0.1023 | 0.4198 | 0.4297 |
| COLO 858 | Vemurafenib | Defactinib | 0.000 | 3.160 | uM | 72 | hr | 2 | 1666 | 709 | 0.1136 | 0.1023 | 0.4256 | 0.4297 |
| WM-115 | Vemurafenib | I-BET151 | 1.000 | 1.000 | uM | 72 | hr | 3 | 1516 | 654 | 0.2471 | 0.2677 | 0.4314 | 0.4255 |
| WM-115 | Vemurafenib | I-BET151 | 1.000 | 1.000 | uM | 72 | hr | 2 | 1659 | 693 | 0.2769 | 0.2677 | 0.4177 | 0.4255 |
| WM-115 | Vemurafenib | I-BET151 | 1.000 | 1.000 | uM | 72 | hr | 1 | 1701 | 727 | 0.2792 | 0.2677 | 0.4274 | 0.4255 |
| COLO 858 | Vemurafenib | Belinostat | 1.000 | 0.000 | uM | 72 | hr | 3 | 1975 | 853 | 0.2574 | 0.2144 | 0.4319 | 0.4251 |
| COLO 858 | Vemurafenib | Belinostat | 1.000 | 0.000 | uM | 72 | hr | 2 | 1665 | 769 | 0.2056 | 0.2144 | 0.4619 | 0.4251 |
| COLO 858 | Vemurafenib | Belinostat | 1.000 | 0.000 | uM | 72 | hr | 1 | 1269 | 484 | 0.1801 | 0.2144 | 0.3814 | 0.4251 |
| MMAC-SF | Vemurafenib | PF562271 | 3.160 | 3.160 | uM | 72 | hr | 3 | 196 | 90 | 0.1073 | 0.1255 | 0.4592 | 0.4181 |
| MMAC-SF | Vemurafenib | PF562271 | 3.160 | 3.160 | uM | 72 | hr | 2 | 191 | 77 | 0.1154 | 0.1255 | 0.4031 | 0.4181 |