Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 1 1609 714 0.1063 0.1023 0.4438 0.4297
MMAC-SF Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 3 664 293 0.2841 0.2946 0.4413 0.4049
COLO 858 Vemurafenib JNK-IN-8 1.000 0.000
uM
 72
hr
 1 1470 646 0.1366 0.1323 0.4395 0.4743
COLO 858 Vemurafenib (+)-JQ1 1.000 0.000
uM
 72
hr
 3 1602 701 0.2735 0.2031 0.4376 0.4582
COLO 858 Vemurafenib I-BET151 1.000 0.000
uM
 72
hr
 2 1148 502 0.1493 0.1445 0.4373 0.4584
A-375 Vemurafenib Belinostat 0.316 1.000
uM
 72
hr
 3 1432 626 0.0615 0.0676 0.4372 0.4031
MMAC-SF Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 2 414 180 0.1442 0.1471 0.4348 0.4142
COLO 858 Vemurafenib Belinostat 1.000 0.000
uM
 72
hr
 3 1975 853 0.2574 0.2144 0.4319 0.4251
WM-115 Vemurafenib I-BET151 1.000 1.000
uM
 72
hr
 3 1516 654 0.2471 0.2677 0.4314 0.4255
WM-115 Vemurafenib (+)-JQ1 0.100 1.000
uM
 72
hr
 2 1817 782 0.3175 0.3130 0.4304 0.4335
WM-115 Vemurafenib JNK-IN-8 1.000 3.160
uM
 72
hr
 3 1841 792 0.2653 0.2705 0.4302 0.4169
COLO 858 Vemurafenib Belinostat 0.100 1.000
uM
 72
hr
 2 1114 477 0.1462 0.1426 0.4282 0.3974
WM-115 Vemurafenib I-BET151 1.000 1.000
uM
 72
hr
 1 1701 727 0.2792 0.2677 0.4274 0.4255
COLO 858 Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 2 2179 931 0.1482 0.1578 0.4273 0.3985
COLO 858 Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 2 1784 762 0.1213 0.1083 0.4271 0.4526
WM-115 Vemurafenib I-BET 1.000 1.000
uM
 72
hr
 3 1611 687 0.2651 0.3008 0.4264 0.4036
COLO 858 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 1 1420 605 0.1381 0.1369 0.4261 0.4519
COLO 858 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 2 1666 709 0.1136 0.1023 0.4256 0.4297
COLO 858 Vemurafenib I-BET 1.000 0.000
uM
 72
hr
 3 1357 576 0.2388 0.1880 0.4245 0.4335
COLO 858 Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 1 1513 641 0.1246 0.1453 0.4237 0.3955
WM-115 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 1 1576 666 0.2272 0.2193 0.4226 0.3870
WM-115 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 3 1300 547 0.2158 0.2243 0.4208 0.4138
A-375 Vemurafenib Belinostat 3.160 1.000
uM
 72
hr
 2 1407 591 0.0623 0.0484 0.4200 0.5323
COLO 858 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 3 1265 531 0.0871 0.1023 0.4198 0.4297
MMAC-SF Vemurafenib Defactinib 1.000 1.000
uM
 72
hr
 3 625 262 0.2237 0.2820 0.4192 0.3755