Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
FTase Inhibitor I
Ftase
MAPK
 100.0000 100.0000 100.0000 0.7715 0.8851 0.9752 0.7468 0.8851 0.9752 0.0000 0.0000 0.0000 0.0099 0.0556 0.0941 100.0000 100.0000 100.0000
Gefitinib
EGFR
ErbB
 6.6704 12.9191 28.3915 -0.2671 0.0424 0.3018 -0.8465 -0.5620 -0.2259 0.9170 1.3719 2.5436 0.0767 0.1382 0.2408 9.0805 26.2291 41.5832
Geldanamycin
HSP90
HSP90
 0.0092 0.0240 0.0425 -0.4324 -0.2962 -0.0904 -0.3507 -0.2347 -0.0323 1.6732 2.3748 3.3908 0.6486 0.7709 0.9035 0.0116 0.0269 0.0560
Gemcitabine
DNA replication
DNA replication
 0.0255 0.1767 1.3221 -0.1534 0.1060 0.2747 -0.1430 0.1441 0.3026 0.5558 1.2204 2.6334 0.3723 0.5392 0.7460 0.0153 0.0741 0.2614
Glycyl-H-1152
ROCK2
N/A
 7.8389 29.5632 100.0000 0.0725 0.4318 0.6407 -0.4259 0.0666 0.6245 0.3449 0.9010 2.0476 0.0704 0.1476 0.1891 2.5420 16.8696 100.0000
GSK1070916
AURK
AURK
 0.6046 3.0981 6.6549 -0.8474 -0.6391 -0.3610 -1.0000 -1.0000 -0.9999 0.6499 0.9902 1.5949 0.2113 0.2924 0.4314 3.5405 8.2453 15.6107
GSK1838705A
IGF1R
RTK
 4.0665 10.9435 23.1329 -0.6969 -0.3849 -0.1067 -0.7773 -0.4275 -0.2150 1.5275 2.6721 3.2208 0.2264 0.2964 0.4149 2.6121 7.6760 17.5013
GSK461364
PLK1
PLK
 0.0087 0.0183 0.0805 -0.6111 -0.4222 -0.2111 -0.4745 -0.3080 -0.0919 2.4728 2.7172 4.9263 0.4701 0.6125 0.7345 0.0105 0.0265 0.3325
GSK923295
CENPE
Kinesin
 0.0392 0.0651 0.2250 -0.5702 -0.2653 -0.0001 -0.5044 -0.2084 0.0089 1.0722 2.1595 3.4297 0.3588 0.4764 0.6241 0.0452 0.0615 1.0057
Ibandronate
FDPS
N/A
 49.3295 82.7741 100.0000 -0.5209 -0.1213 0.0387 -0.7048 -0.2169 -0.0113 0.9599 1.4483 1.9155 0.2062 0.2750 0.3199 66.6332 98.6899 100.0000
ICRF-193
TOP2
TOP
 8.5852 100.0000 100.0000 0.3561 0.5910 0.6710 0.2252 0.4446 0.6698 0.1440 0.6745 1.5658 0.1152 0.1622 0.2393 0.3708 3.7956 100.0000
IKK16
IKK
NFKB
 1.8767 3.1049 3.8519 -0.9668 -0.9445 -0.8619 -0.9890 -0.9578 -0.8641 2.2018 3.4729 4.3592 0.3739 0.4332 0.4763 3.1521 4.0389 4.8853
Imatinib
ABL/KIT/PDGFR
nRTK
 18.5481 21.7914 25.5570 -0.9852 -0.9632 -0.8948 -0.9969 -0.9814 -0.8936 2.2328 2.7060 3.3541 0.3997 0.4467 0.4851 27.9144 31.9309 36.9254
Ispinesib
KSP
Kinesin
 0.0263 0.0439 0.1261 -0.9817 -0.9567 -0.8688 -1.0000 -0.9800 -0.6258 0.4997 1.2912 3.1780 0.5293 0.6720 0.8104 0.0357 0.4315 1.3590
Ixabepilone
TUBB
TUBB
 0.0045 0.0114 0.0487 -0.9765 -0.9460 -0.8485 -0.9892 -0.7196 -0.5742 0.3937 0.7623 1.6684 0.6842 0.8505 0.9658 0.0102 0.0892 0.7025
JNK-IN-5A
JNK
JNK
 1.8491 14.2132 100.0000 -0.1818 0.1302 0.4971 -0.4099 0.0435 0.4984 0.0000 3.1821 4.9999 0.0989 0.2367 0.3549 1.4898 12.5032 100.0000
L-779450
BRAF
MAPK
 12.8318 28.9246 48.0158 -0.2622 0.2749 0.3891 -1.0000 -0.6190 -0.1023 1.0435 1.8204 3.7221 0.0544 0.0922 0.1394 20.7244 44.1580 61.2878
Lapatinib
EGFR/HER2
ErbB
 31.2806 100.0000 100.0000 0.4954 0.7950 0.9113 0.2428 0.7519 0.9066 0.0000 0.2457 1.3492 0.0247 0.0703 0.1302 1.5972 63.5403 100.0000
LBH589
HDAC
HDAC
 0.0792 0.1432 0.2719 -0.9159 -0.8072 -0.7128 -0.9155 -0.7955 -0.6832 1.1720 1.5004 2.1649 0.5471 0.6739 0.7846 0.1472 0.2600 0.4626
Lestaurtinib
FLT3/JAK2/TrkA
RTK
 0.2491 0.7096 1.5478 -0.9565 -0.8762 -0.7290 -1.0000 -1.0000 -0.9202 0.6212 0.8572 1.4388 0.3615 0.4228 0.5481 1.3258 2.5025 5.3389
Mebendazole
N/A
N/A
 0.2591 0.5241 2.5192 -0.2079 0.0053 0.2103 -0.2699 -0.1133 0.2272 0.7947 1.2360 1.9961 0.2868 0.3432 0.4692 0.3151 0.3915 2.6571
Methotrexate
DHFR
Metabolism
 0.1850 100.0000 100.0000 0.3067 0.6372 0.9078 0.3672 0.5884 0.9117 0.0000 2.3582 4.5415 0.0328 0.2767 0.4502 0.0331 0.1737 100.0000
MG-132
Proteasome
Proteasome
 0.1071 0.1768 0.5078 -0.8632 -0.7505 -0.5413 -0.8499 -0.6667 -0.5123 1.5044 2.4128 3.5768 0.6530 0.7329 0.8677 0.1559 0.2469 1.0059
Nelfinavir
N/A
N/A
 8.4034 9.7440 15.4339 -0.8211 -0.6445 -0.2989 -1.0000 -1.0000 -0.8006 1.6805 2.3548 2.7767 0.1130 0.1589 0.1970 12.4011 15.3815 22.7642
Nilotinib
ABL
nRTK
 100.0000 100.0000 100.0000 0.7849 0.9109 1.0055 0.7841 0.9109 1.0055 0.0000 0.0000 0.7234 0.0029 0.0487 0.0775 73.6076 100.0000 100.0000