Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
Valproic acid
HDAC
HDAC
 100.0000 100.0000 100.0000 -0.8969 -0.6820 -0.4277 -0.5381 -0.3207 -0.1180 1.1443 1.2884 1.4704 0.1935 0.2464 0.2891 100.0000 100.0000 100.0000
Oxamflatin
HDAC
HDAC
 0.6664 0.9513 1.6592 -0.9525 -0.8858 -0.8199 -1.0000 -0.9857 -0.8929 1.0334 1.2610 1.4776 0.4375 0.5175 0.6006 1.6681 2.6703 3.8183
ICRF-193
TOP2
TOP
 8.5852 100.0000 100.0000 0.3561 0.5910 0.6710 0.2252 0.4446 0.6698 0.1440 0.6745 1.5658 0.1152 0.1622 0.2393 0.3708 3.7956 100.0000
GSK1070916
AURK
AURK
 0.6046 3.0981 6.6549 -0.8474 -0.6391 -0.3610 -1.0000 -1.0000 -0.9999 0.6499 0.9902 1.5949 0.2113 0.2924 0.4314 3.5405 8.2453 15.6107
Vorinostat
HDAC
HDAC
 72.1503 100.0000 100.0000 -0.8970 -0.8099 -0.5591 -0.9320 -0.8403 -0.5970 1.0273 1.3201 1.6251 0.4794 0.5820 0.7389 100.0000 100.0000 100.0000
Ixabepilone
TUBB
TUBB
 0.0045 0.0114 0.0487 -0.9765 -0.9460 -0.8485 -0.9892 -0.7196 -0.5742 0.3937 0.7623 1.6684 0.6842 0.8505 0.9658 0.0102 0.0892 0.7025
Afatinib
EGFR/HER2
ErbB
 0.1253 1.5517 2.4757 -0.9553 -0.9200 -0.8460 -1.0000 -1.0000 -0.9391 0.5080 1.0283 1.7263 0.4620 0.5435 0.6679 1.1116 3.3143 4.9447
Trametinib
MEK
MAPK
 0.1119 60.3200 100.0000 0.2676 0.5669 0.7582 0.2515 0.4183 0.5896 0.4854 1.1532 1.7735 0.0718 0.1864 0.3779 0.0100 0.4479 33.6419
Erlotinib
EGFR
ErbB
 6.4716 35.2468 100.0000 0.0317 0.4006 0.6354 -0.8374 -0.1704 0.3788 0.3155 0.7139 1.8126 0.0351 0.1228 0.2396 13.2839 41.2968 100.0000
Pemetrexed
TYMS/DHFR/GARFT
TYMS
 70.1583 100.0000 100.0000 0.5012 0.6411 0.8577 0.5144 0.6941 0.8649 0.0000 0.7943 1.8547 0.0614 0.1870 0.3357 0.9463 34.1832 100.0000
CPT-11
TOP1
TOP
 3.1544 10.7270 20.8553 -0.5980 -0.2192 0.1666 -0.9688 -0.6234 -0.1292 0.8799 1.3528 1.8883 0.1220 0.2195 0.2928 7.3583 23.7091 36.8667
Ibandronate
FDPS
N/A
 49.3295 82.7741 100.0000 -0.5209 -0.1213 0.0387 -0.7048 -0.2169 -0.0113 0.9599 1.4483 1.9155 0.2062 0.2750 0.3199 66.6332 98.6899 100.0000
Bosutinib
Src
nRTK
 1.2187 1.7497 4.1420 -0.6727 -0.4219 -0.1512 -0.7662 -0.4684 -0.1288 0.9612 1.6575 1.9534 0.3079 0.3819 0.4639 1.7722 2.5602 5.3523
FR180204
ERK1/2
MAPK
 56.2203 100.0000 100.0000 0.4862 0.6317 0.8238 -0.1433 0.2500 0.7055 0.0180 0.6403 1.9539 0.0470 0.0722 0.1058 65.9938 100.0000 100.0000
Mebendazole
N/A
N/A
 0.2591 0.5241 2.5192 -0.2079 0.0053 0.2103 -0.2699 -0.1133 0.2272 0.7947 1.2360 1.9961 0.2868 0.3432 0.4692 0.3151 0.3915 2.6571
Sigma A6730
AKT
AKT
 2.0327 6.5660 11.2198 -0.9178 -0.8320 -0.6777 -1.0000 -1.0000 -0.9546 0.9310 1.3794 2.0044 0.2439 0.2875 0.4042 6.3004 13.6236 19.0461
Glycyl-H-1152
ROCK2
N/A
 7.8389 29.5632 100.0000 0.0725 0.4318 0.6407 -0.4259 0.0666 0.6245 0.3449 0.9010 2.0476 0.0704 0.1476 0.1891 2.5420 16.8696 100.0000
Epirubicin
TOP2
TOP
 0.2120 0.3019 0.4930 -0.9915 -0.9463 -0.8152 -0.8492 -0.7437 -0.6556 0.9325 1.4047 2.1457 0.6134 0.7438 0.8467 0.3985 0.6015 1.3650
Carboplatin
DNA cross-linker
DNA cross-linker
 30.4522 52.4276 91.0569 -0.9081 -0.7672 -0.5844 -0.9460 -0.8644 -0.7390 1.2433 1.6402 2.1619 0.2714 0.3706 0.4859 52.1319 91.7409 100.0000
LBH589
HDAC
HDAC
 0.0792 0.1432 0.2719 -0.9159 -0.8072 -0.7128 -0.9155 -0.7955 -0.6832 1.1720 1.5004 2.1649 0.5471 0.6739 0.7846 0.1472 0.2600 0.4626
Cisplatin
DNA cross-linker
DNA cross-linker
 4.4823 11.6380 25.2438 -0.8850 -0.6449 -0.2565 -0.9047 -0.5931 -0.2921 1.0217 1.3698 2.2177 0.2715 0.3752 0.4391 8.7984 21.1543 38.4325
Trichostatin A
HDAC
HDAC
 6.5374 11.5225 17.5553 -0.9202 -0.8512 -0.7541 -0.9053 -0.8178 -0.6756 1.3647 1.8955 2.2777 0.6490 0.7724 0.9158 11.0302 20.2024 30.2620
TPCA-1
IKK
NFKB
 4.9121 23.5816 100.0000 0.0988 0.4346 0.6277 -0.1071 0.3912 0.5674 0.5796 1.2158 2.2892 0.0966 0.1616 0.2244 2.5700 5.7466 43.2238
Docetaxel
TUBB
TUBB
 0.0022 0.0051 0.0098 -0.3944 -0.0464 0.1697 -0.4257 -0.0477 0.1373 1.4024 1.6746 2.3040 0.4979 0.6215 0.8198 0.0027 0.0049 0.0080
SB-3CT
MMP2/9
MMP
 69.9094 100.0000 100.0000 0.4441 0.6795 0.8316 -0.1049 0.6210 0.7846 0.0670 0.6905 2.4960 0.0290 0.0754 0.1306 27.8608 93.1362 100.0000