Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
AG1024
IGF1R
RTK
 14.2327 62.8199 100.0000 0.3069 0.5828 0.8614 -0.0340 0.2904 0.6353 0.3280 1.4424 3.0172 0.0186 0.0785 0.1208 8.3409 30.1991 100.0000
Selumetinib
MEK
MAPK
 3.4703 100.0000 100.0000 0.2888 0.6993 0.8618 0.1384 0.6524 0.8687 0.0000 0.4990 0.9393 0.0510 0.1233 0.3040 0.3246 2.6951 100.0000
ICRF-193
TOP2
TOP
 8.5852 100.0000 100.0000 0.3561 0.5910 0.6710 0.2252 0.4446 0.6698 0.1440 0.6745 1.5658 0.1152 0.1622 0.2393 0.3708 3.7956 100.0000
Dactolisib
PI3K
PI3K
 0.1885 0.5181 100.0000 0.2549 0.5042 0.6208 0.2262 0.4314 0.5885 0.0000 2.2633 4.9147 0.2133 0.2744 0.3494 0.1148 0.3521 100.0000
Lapatinib
EGFR/HER2
ErbB
 31.2806 100.0000 100.0000 0.4954 0.7950 0.9113 0.2428 0.7519 0.9066 0.0000 0.2457 1.3492 0.0247 0.0703 0.1302 1.5972 63.5403 100.0000
Trametinib
MEK
MAPK
 0.1119 60.3200 100.0000 0.2676 0.5669 0.7582 0.2515 0.4183 0.5896 0.4854 1.1532 1.7735 0.0718 0.1864 0.3779 0.0100 0.4479 33.6419
TCS PIM-1 1
Pim kinase
PIM
 90.9415 100.0000 100.0000 0.4852 0.6734 0.7827 0.3505 0.5918 0.7255 0.0000 1.5057 4.5238 0.0404 0.0756 0.1063 26.3980 73.0639 100.0000
Methotrexate
DHFR
Metabolism
 0.1850 100.0000 100.0000 0.3067 0.6372 0.9078 0.3672 0.5884 0.9117 0.0000 2.3582 4.5415 0.0328 0.2767 0.4502 0.0331 0.1737 100.0000
Ribavirin
N/A
N/A
 100.0000 100.0000 100.0000 0.6045 0.7146 0.9546 0.4725 0.6701 0.9546 0.0000 0.0000 0.9838 0.0119 0.0416 0.0703 50.4745 100.0000 100.0000
Pemetrexed
TYMS/DHFR/GARFT
TYMS
 70.1583 100.0000 100.0000 0.5012 0.6411 0.8577 0.5144 0.6941 0.8649 0.0000 0.7943 1.8547 0.0614 0.1870 0.3357 0.9463 34.1832 100.0000
Cetuximab
EGFR
ErbB
 100.0000 100.0000 100.0000 0.7284 0.8755 0.9754 0.5964 0.8555 0.9754 0.0000 0.0000 0.7916 -0.0099 0.0234 0.0674 3.7461 100.0000 100.0000
FTase Inhibitor I
Ftase
MAPK
 100.0000 100.0000 100.0000 0.7715 0.8851 0.9752 0.7468 0.8851 0.9752 0.0000 0.0000 0.0000 0.0099 0.0556 0.0941 100.0000 100.0000 100.0000
Nilotinib
ABL
nRTK
 100.0000 100.0000 100.0000 0.7849 0.9109 1.0055 0.7841 0.9109 1.0055 0.0000 0.0000 0.7234 0.0029 0.0487 0.0775 73.6076 100.0000 100.0000
Dichloroacetate
PDK
PDK
 100.0000 100.0000 100.0000 0.8082 0.8801 0.9216 0.7946 0.8670 0.9296 0.0000 0.0000 0.2064 0.0234 0.0440 0.0744 58.3872 100.0000 100.0000
PS-1145
IKK
NFKB
 100.0000 100.0000 100.0000 0.8452 0.9304 0.9718 0.8353 0.9304 0.9695 0.0000 0.0000 0.8067 -0.0033 0.0200 0.0533 100.0000 100.0000 100.0000