Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
NU6102
CDK1/2
CDK
 12.2242 17.3275 31.6450 -0.7759 -0.4783 -0.1439 -1.0000 -0.9972 -0.6085 1.3221 1.8051 3.6950 0.1178 0.1554 0.2440 20.2928 27.4520 55.8294
PD173074
FGFR1/3
RTK
 7.0478 8.9285 13.6750 -0.8719 -0.6669 -0.2130 -1.0000 -0.9488 -0.5559 1.6563 2.2671 4.5022 0.0991 0.1926 0.2504 8.7381 13.6708 21.0369
Valproic acid
HDAC
HDAC
 100.0000 100.0000 100.0000 -0.8969 -0.6820 -0.4277 -0.5381 -0.3207 -0.1180 1.1443 1.2884 1.4704 0.1935 0.2464 0.2891 100.0000 100.0000 100.0000
CPT-11
TOP1
TOP
 3.1544 10.7270 20.8553 -0.5980 -0.2192 0.1666 -0.9688 -0.6234 -0.1292 0.8799 1.3528 1.8883 0.1220 0.2195 0.2928 7.3583 23.7091 36.8667
AG1478
EGFR
ErbB
 8.7673 51.6075 100.0000 -0.0710 0.2684 0.6341 -0.3109 -0.0273 0.4206 0.8939 1.7205 2.6373 0.0902 0.1531 0.2936 3.7212 36.6666 94.4655
Sorafenib
PDGFR/VEGFR/KIT/FLT3
RTK
 36.5873 68.4588 100.0000 -0.7737 -0.2023 0.2203 -0.7439 -0.3900 0.2345 0.6570 1.9429 3.4993 0.1339 0.2188 0.2978 54.8881 71.4700 100.0000
ZM-447439
AURK
AURK
 3.5193 19.1991 100.0000 -0.0403 0.4141 0.5578 -0.1176 0.3301 0.5652 0.5578 1.0337 2.9596 0.1428 0.2012 0.3024 0.6732 2.5837 16.4745
Selumetinib
MEK
MAPK
 3.4703 100.0000 100.0000 0.2888 0.6993 0.8618 0.1384 0.6524 0.8687 0.0000 0.4990 0.9393 0.0510 0.1233 0.3040 0.3246 2.6951 100.0000
Ibandronate
FDPS
N/A
 49.3295 82.7741 100.0000 -0.5209 -0.1213 0.0387 -0.7048 -0.2169 -0.0113 0.9599 1.4483 1.9155 0.2062 0.2750 0.3199 66.6332 98.6899 100.0000
Pemetrexed
TYMS/DHFR/GARFT
TYMS
 70.1583 100.0000 100.0000 0.5012 0.6411 0.8577 0.5144 0.6941 0.8649 0.0000 0.7943 1.8547 0.0614 0.1870 0.3357 0.9463 34.1832 100.0000
Dactolisib
PI3K
PI3K
 0.1885 0.5181 100.0000 0.2549 0.5042 0.6208 0.2262 0.4314 0.5885 0.0000 2.2633 4.9147 0.2133 0.2744 0.3494 0.1148 0.3521 100.0000
JNK-IN-5A
JNK
JNK
 1.8491 14.2132 100.0000 -0.1818 0.1302 0.4971 -0.4099 0.0435 0.4984 0.0000 3.1821 4.9999 0.0989 0.2367 0.3549 1.4898 12.5032 100.0000
Disulfiram
Proteasome
Proteasome
 0.2148 13.4616 100.0000 -0.6139 0.0054 0.4486 -0.9836 -0.0088 0.5061 0.2242 2.0208 4.9998 0.1469 0.2459 0.3654 0.1623 16.2617 100.0000
Tozasertib
AURK/FLT3/ABL/JAK2
AURK
 0.9523 4.3787 11.8540 -0.5661 -0.3376 -0.0359 -1.0000 -1.0000 -0.4350 0.4858 0.8218 1.3502 0.1794 0.3014 0.3656 4.7346 16.5294 34.8041
Trametinib
MEK
MAPK
 0.1119 60.3200 100.0000 0.2676 0.5669 0.7582 0.2515 0.4183 0.5896 0.4854 1.1532 1.7735 0.0718 0.1864 0.3779 0.0100 0.4479 33.6419
5-DFUR
TYMS
TYMS
 68.5295 100.0000 100.0000 -0.1871 -0.0208 0.0399 -0.5625 -0.3158 -0.1425 0.3943 0.5084 0.6195 0.2584 0.3100 0.3856 100.0000 100.0000 100.0000
Olomoucine II
CDK1
CDK
 3.7444 6.0358 7.3956 -0.7023 -0.3927 -0.1441 -0.7230 -0.4357 -0.1137 1.4260 2.7083 4.7257 0.2563 0.3202 0.3981 5.9885 7.0813 8.6384
Sigma A6730
AKT
AKT
 2.0327 6.5660 11.2198 -0.9178 -0.8320 -0.6777 -1.0000 -1.0000 -0.9546 0.9310 1.3794 2.0044 0.2439 0.2875 0.4042 6.3004 13.6236 19.0461
GSK1838705A
IGF1R
RTK
 4.0665 10.9435 23.1329 -0.6969 -0.3849 -0.1067 -0.7773 -0.4275 -0.2150 1.5275 2.6721 3.2208 0.2264 0.2964 0.4149 2.6121 7.6760 17.5013
GSK1070916
AURK
AURK
 0.6046 3.0981 6.6549 -0.8474 -0.6391 -0.3610 -1.0000 -1.0000 -0.9999 0.6499 0.9902 1.5949 0.2113 0.2924 0.4314 3.5405 8.2453 15.6107
Cisplatin
DNA cross-linker
DNA cross-linker
 4.4823 11.6380 25.2438 -0.8850 -0.6449 -0.2565 -0.9047 -0.5931 -0.2921 1.0217 1.3698 2.2177 0.2715 0.3752 0.4391 8.7984 21.1543 38.4325
Methotrexate
DHFR
Metabolism
 0.1850 100.0000 100.0000 0.3067 0.6372 0.9078 0.3672 0.5884 0.9117 0.0000 2.3582 4.5415 0.0328 0.2767 0.4502 0.0331 0.1737 100.0000
XRP44X
ELK3
MAPK
 0.7816 1.1482 1.8976 -0.2021 0.0602 0.2789 -0.1369 0.0575 0.2934 1.8769 3.3942 4.9998 0.2905 0.3686 0.4637 0.6561 1.0109 1.3678
Bosutinib
Src
nRTK
 1.2187 1.7497 4.1420 -0.6727 -0.4219 -0.1512 -0.7662 -0.4684 -0.1288 0.9612 1.6575 1.9534 0.3079 0.3819 0.4639 1.7722 2.5602 5.3523
Mebendazole
N/A
N/A
 0.2591 0.5241 2.5192 -0.2079 0.0053 0.2103 -0.2699 -0.1133 0.2272 0.7947 1.2360 1.9961 0.2868 0.3432 0.4692 0.3151 0.3915 2.6571