Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
Nelfinavir
N/A
N/A
 8.4034 9.7440 15.4339 -0.8211 -0.6445 -0.2989 -1.0000 -1.0000 -0.8006 1.6805 2.3548 2.7767 0.1130 0.1589 0.1970 12.4011 15.3815 22.7642
TPCA-1
IKK
NFKB
 4.9121 23.5816 100.0000 0.0988 0.4346 0.6277 -0.1071 0.3912 0.5674 0.5796 1.2158 2.2892 0.0966 0.1616 0.2244 2.5700 5.7466 43.2238
ICRF-193
TOP2
TOP
 8.5852 100.0000 100.0000 0.3561 0.5910 0.6710 0.2252 0.4446 0.6698 0.1440 0.6745 1.5658 0.1152 0.1622 0.2393 0.3708 3.7956 100.0000
Trametinib
MEK
MAPK
 0.1119 60.3200 100.0000 0.2676 0.5669 0.7582 0.2515 0.4183 0.5896 0.4854 1.1532 1.7735 0.0718 0.1864 0.3779 0.0100 0.4479 33.6419
Pemetrexed
TYMS/DHFR/GARFT
TYMS
 70.1583 100.0000 100.0000 0.5012 0.6411 0.8577 0.5144 0.6941 0.8649 0.0000 0.7943 1.8547 0.0614 0.1870 0.3357 0.9463 34.1832 100.0000
PD173074
FGFR1/3
RTK
 7.0478 8.9285 13.6750 -0.8719 -0.6669 -0.2130 -1.0000 -0.9488 -0.5559 1.6563 2.2671 4.5022 0.0991 0.1926 0.2504 8.7381 13.6708 21.0369
ZM-447439
AURK
AURK
 3.5193 19.1991 100.0000 -0.0403 0.4141 0.5578 -0.1176 0.3301 0.5652 0.5578 1.0337 2.9596 0.1428 0.2012 0.3024 0.6732 2.5837 16.4745
Sorafenib
PDGFR/VEGFR/KIT/FLT3
RTK
 36.5873 68.4588 100.0000 -0.7737 -0.2023 0.2203 -0.7439 -0.3900 0.2345 0.6570 1.9429 3.4993 0.1339 0.2188 0.2978 54.8881 71.4700 100.0000
CPT-11
TOP1
TOP
 3.1544 10.7270 20.8553 -0.5980 -0.2192 0.1666 -0.9688 -0.6234 -0.1292 0.8799 1.3528 1.8883 0.1220 0.2195 0.2928 7.3583 23.7091 36.8667
JNK-IN-5A
JNK
JNK
 1.8491 14.2132 100.0000 -0.1818 0.1302 0.4971 -0.4099 0.0435 0.4984 0.0000 3.1821 4.9999 0.0989 0.2367 0.3549 1.4898 12.5032 100.0000
Disulfiram
Proteasome
Proteasome
 0.2148 13.4616 100.0000 -0.6139 0.0054 0.4486 -0.9836 -0.0088 0.5061 0.2242 2.0208 4.9998 0.1469 0.2459 0.3654 0.1623 16.2617 100.0000
Valproic acid
HDAC
HDAC
 100.0000 100.0000 100.0000 -0.8969 -0.6820 -0.4277 -0.5381 -0.3207 -0.1180 1.1443 1.2884 1.4704 0.1935 0.2464 0.2891 100.0000 100.0000 100.0000
Dactolisib
PI3K
PI3K
 0.1885 0.5181 100.0000 0.2549 0.5042 0.6208 0.2262 0.4314 0.5885 0.0000 2.2633 4.9147 0.2133 0.2744 0.3494 0.1148 0.3521 100.0000
Ibandronate
FDPS
N/A
 49.3295 82.7741 100.0000 -0.5209 -0.1213 0.0387 -0.7048 -0.2169 -0.0113 0.9599 1.4483 1.9155 0.2062 0.2750 0.3199 66.6332 98.6899 100.0000
Methotrexate
DHFR
Metabolism
 0.1850 100.0000 100.0000 0.3067 0.6372 0.9078 0.3672 0.5884 0.9117 0.0000 2.3582 4.5415 0.0328 0.2767 0.4502 0.0331 0.1737 100.0000
Sigma A6730
AKT
AKT
 2.0327 6.5660 11.2198 -0.9178 -0.8320 -0.6777 -1.0000 -1.0000 -0.9546 0.9310 1.3794 2.0044 0.2439 0.2875 0.4042 6.3004 13.6236 19.0461
GSK1070916
AURK
AURK
 0.6046 3.0981 6.6549 -0.8474 -0.6391 -0.3610 -1.0000 -1.0000 -0.9999 0.6499 0.9902 1.5949 0.2113 0.2924 0.4314 3.5405 8.2453 15.6107
GSK1838705A
IGF1R
RTK
 4.0665 10.9435 23.1329 -0.6969 -0.3849 -0.1067 -0.7773 -0.4275 -0.2150 1.5275 2.6721 3.2208 0.2264 0.2964 0.4149 2.6121 7.6760 17.5013
Tozasertib
AURK/FLT3/ABL/JAK2
AURK
 0.9523 4.3787 11.8540 -0.5661 -0.3376 -0.0359 -1.0000 -1.0000 -0.4350 0.4858 0.8218 1.3502 0.1794 0.3014 0.3656 4.7346 16.5294 34.8041
5-DFUR
TYMS
TYMS
 68.5295 100.0000 100.0000 -0.1871 -0.0208 0.0399 -0.5625 -0.3158 -0.1425 0.3943 0.5084 0.6195 0.2584 0.3100 0.3856 100.0000 100.0000 100.0000
Triciribine
AKT
AKT
 0.1497 1.0069 10.2321 -0.2208 0.0730 0.3595 -0.6783 -0.3270 0.0049 0.3693 0.5173 0.9769 0.1961 0.3180 0.4712 0.2958 1.3169 18.2553
Olomoucine II
CDK1
CDK
 3.7444 6.0358 7.3956 -0.7023 -0.3927 -0.1441 -0.7230 -0.4357 -0.1137 1.4260 2.7083 4.7257 0.2563 0.3202 0.3981 5.9885 7.0813 8.6384
Mebendazole
N/A
N/A
 0.2591 0.5241 2.5192 -0.2079 0.0053 0.2103 -0.2699 -0.1133 0.2272 0.7947 1.2360 1.9961 0.2868 0.3432 0.4692 0.3151 0.3915 2.6571
XRP44X
ELK3
MAPK
 0.7816 1.1482 1.8976 -0.2021 0.0602 0.2789 -0.1369 0.0575 0.2934 1.8769 3.3942 4.9998 0.2905 0.3686 0.4637 0.6561 1.0109 1.3678
Carboplatin
DNA cross-linker
DNA cross-linker
 30.4522 52.4276 91.0569 -0.9081 -0.7672 -0.5844 -0.9460 -0.8644 -0.7390 1.2433 1.6402 2.1619 0.2714 0.3706 0.4859 52.1319 91.7409 100.0000