Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. - Dataset (ID:20270)

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Small Molecule Antibody Perturbagen Target Perturbagen Class GR50 lower quartile GR50 median GR50 upper quartile GRmax lower quartile GRmax median GRmax upper quartile GRinf lower quartile GRinf median GRinf upper quartile Hill Coefficient lower quartile Hill Coefficient median Hill Coefficient upper quartile GR_AOC lower quartile GR_AOC median GR_AOC upper quartile GEC50 lower quartile GEC50 median GEC50 upper quartile
Purvalanol A
CDK1
CDK
 25.2896 54.7310 100.0000 0.0757 0.5333 0.7416 -0.0675 0.5068 0.7450 1.0817 2.5000 4.2404 0.0335 0.0774 0.1767 18.1854 35.4887 52.3768
PS-1145
IKK
NFKB
 100.0000 100.0000 100.0000 0.8452 0.9304 0.9718 0.8353 0.9304 0.9695 0.0000 0.0000 0.8067 -0.0033 0.0200 0.0533 100.0000 100.0000 100.0000
Pevonedistat
NAE1
NAE1
 0.1439 0.3445 1.2615 -0.3074 -0.0880 0.0407 -0.4612 -0.1540 0.0480 0.6476 0.9529 1.4328 0.3433 0.4344 0.5442 0.1672 0.7014 1.4696
Pemetrexed
TYMS/DHFR/GARFT
TYMS
 70.1583 100.0000 100.0000 0.5012 0.6411 0.8577 0.5144 0.6941 0.8649 0.0000 0.7943 1.8547 0.0614 0.1870 0.3357 0.9463 34.1832 100.0000
PD 98059
MEK
MAPK
 100.0000 100.0000 100.0000 0.5235 0.6650 0.8191 -0.1517 0.5395 0.8149 0.0000 0.2473 0.7779 0.0463 0.0842 0.1501 32.4005 100.0000 100.0000
PD184352
MEK
MAPK
 31.0822 100.0000 100.0000 0.4258 0.7584 0.9084 -0.2272 0.7139 0.9084 0.0000 0.0524 0.4766 0.0368 0.0888 0.1432 63.7076 100.0000 100.0000
PD173074
FGFR1/3
RTK
 7.0478 8.9285 13.6750 -0.8719 -0.6669 -0.2130 -1.0000 -0.9488 -0.5559 1.6563 2.2671 4.5022 0.0991 0.1926 0.2504 8.7381 13.6708 21.0369
Oxamflatin
HDAC
HDAC
 0.6664 0.9513 1.6592 -0.9525 -0.8858 -0.8199 -1.0000 -0.9857 -0.8929 1.0334 1.2610 1.4776 0.4375 0.5175 0.6006 1.6681 2.6703 3.8183
Oxaliplatin
DNA cross-linker
DNA cross-linker
 3.2681 4.9333 12.0662 -0.9391 -0.8084 -0.7104 -1.0000 -1.0000 -0.9516 0.6228 0.7486 1.0057 0.4005 0.5419 0.5768 14.7918 22.6957 42.6124
Omipalisib
PI3K
PI3K
 0.0049 0.0154 0.0397 -0.8281 -0.5752 -0.4164 -0.8004 -0.5070 -0.2908 0.6200 0.7592 0.9464 0.6332 0.8101 0.9689 0.0158 0.0370 0.0945
Olomoucine II
CDK1
CDK
 3.7444 6.0358 7.3956 -0.7023 -0.3927 -0.1441 -0.7230 -0.4357 -0.1137 1.4260 2.7083 4.7257 0.2563 0.3202 0.3981 5.9885 7.0813 8.6384
Nutlin 3a
MDM2
MDM2
 15.2348 24.3890 41.8634 -0.3252 -0.0482 0.2155 -1.0000 -0.8163 -0.2697 1.1456 1.7429 2.5635 0.0828 0.1397 0.2099 23.6810 39.7952 62.9892
NU6102
CDK1/2
CDK
 12.2242 17.3275 31.6450 -0.7759 -0.4783 -0.1439 -1.0000 -0.9972 -0.6085 1.3221 1.8051 3.6950 0.1178 0.1554 0.2440 20.2928 27.4520 55.8294
NSC 663284
CDC25
CDC
 1.6689 2.2519 3.0742 -0.9668 -0.9336 -0.8607 -0.9846 -0.9413 -0.8554 1.8405 2.5456 4.2988 0.5484 0.5805 0.6318 2.2603 3.4718 5.7633
Nilotinib
ABL
nRTK
 100.0000 100.0000 100.0000 0.7849 0.9109 1.0055 0.7841 0.9109 1.0055 0.0000 0.0000 0.7234 0.0029 0.0487 0.0775 73.6076 100.0000 100.0000
Nelfinavir
N/A
N/A
 8.4034 9.7440 15.4339 -0.8211 -0.6445 -0.2989 -1.0000 -1.0000 -0.8006 1.6805 2.3548 2.7767 0.1130 0.1589 0.1970 12.4011 15.3815 22.7642
MG-132
Proteasome
Proteasome
 0.1071 0.1768 0.5078 -0.8632 -0.7505 -0.5413 -0.8499 -0.6667 -0.5123 1.5044 2.4128 3.5768 0.6530 0.7329 0.8677 0.1559 0.2469 1.0059
Methotrexate
DHFR
Metabolism
 0.1850 100.0000 100.0000 0.3067 0.6372 0.9078 0.3672 0.5884 0.9117 0.0000 2.3582 4.5415 0.0328 0.2767 0.4502 0.0331 0.1737 100.0000
Mebendazole
N/A
N/A
 0.2591 0.5241 2.5192 -0.2079 0.0053 0.2103 -0.2699 -0.1133 0.2272 0.7947 1.2360 1.9961 0.2868 0.3432 0.4692 0.3151 0.3915 2.6571
Lestaurtinib
FLT3/JAK2/TrkA
RTK
 0.2491 0.7096 1.5478 -0.9565 -0.8762 -0.7290 -1.0000 -1.0000 -0.9202 0.6212 0.8572 1.4388 0.3615 0.4228 0.5481 1.3258 2.5025 5.3389
LBH589
HDAC
HDAC
 0.0792 0.1432 0.2719 -0.9159 -0.8072 -0.7128 -0.9155 -0.7955 -0.6832 1.1720 1.5004 2.1649 0.5471 0.6739 0.7846 0.1472 0.2600 0.4626
Lapatinib
EGFR/HER2
ErbB
 31.2806 100.0000 100.0000 0.4954 0.7950 0.9113 0.2428 0.7519 0.9066 0.0000 0.2457 1.3492 0.0247 0.0703 0.1302 1.5972 63.5403 100.0000
L-779450
BRAF
MAPK
 12.8318 28.9246 48.0158 -0.2622 0.2749 0.3891 -1.0000 -0.6190 -0.1023 1.0435 1.8204 3.7221 0.0544 0.0922 0.1394 20.7244 44.1580 61.2878
JNK-IN-5A
JNK
JNK
 1.8491 14.2132 100.0000 -0.1818 0.1302 0.4971 -0.4099 0.0435 0.4984 0.0000 3.1821 4.9999 0.0989 0.2367 0.3549 1.4898 12.5032 100.0000
Ixabepilone
TUBB
TUBB
 0.0045 0.0114 0.0487 -0.9765 -0.9460 -0.8485 -0.9892 -0.7196 -0.5742 0.3937 0.7623 1.6684 0.6842 0.8505 0.9658 0.0102 0.0892 0.7025