Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47DKBLUC | Unknown | Unknown | Ixabepilone | TUBB | TUBB | 7544.095 | uM | 0.02431 | 1.10150 | -0.9737 | -1.0000 | 0.2881 | 0.6556 | 0.6937 | 1.0175 | |
| T47DKBLUC | Unknown | Unknown | Ixabepilone | TUBB | TUBB | 7545.095 | uM | 0.00970 | 0.02021 | -0.9795 | -0.3082 | 0.6544 | 0.7119 | 0.7269 | 1.0123 | |
| T47DKBLUC | Unknown | Unknown | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12608.167 | uM | 7.00030 | 8.19070 | -0.5949 | -0.5964 | 4.9993 | 0.1398 | 0.9962 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | Mebendazole | 13070.174 | uM | 6.44240 | 149.04650 | -0.0794 | -1.0000 | 0.3497 | 0.2663 | 0.7011 | 0.7993 | |||
| T47DKBLUC | Unknown | Unknown | Methylglyoxal | 13070.184 | uM | 508.29240 | 1000.00000 | -0.9924 | -0.8019 | 1.4142 | 0.5414 | 0.9222 | 0.8653 | |||
| T47DKBLUC | Unknown | Unknown | LBH589 | HDAC | HDAC | 12608.167 | uM | 0.14055 | 0.24910 | -0.9323 | -0.9558 | 1.8674 | 0.7486 | 0.9989 | 1.2681 | |
| T47DKBLUC | Unknown | Unknown | PD173074 | FGFR1/3 | RTK | 7545.1 | uM | 17.05940 | 30.44070 | -0.6468 | -1.0000 | 1.8972 | 0.2343 | 0.9490 | 1.1396 | |
| T47DKBLUC | Unknown | Unknown | PD173074 | FGFR1/3 | RTK | 7544.093 | uM | 8.09160 | 11.64830 | -0.9258 | -1.0000 | 3.0154 | 0.2267 | 0.9758 | 1.2382 | |
| T47DKBLUC | Unknown | Unknown | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7546.095 | uM | 0.24555 | 0.14696 | 0.2826 | 0.3262 | 2.0588 | 0.5126 | 0.9837 | 0.8399 | |
| T47DKBLUC | Unknown | Unknown | PS-1145 | IKK | NFKB | 7546.065 | uM | inf | inf | 0.9695 | 0.9695 | 0.0000 | 0.0204 | 0.0000 | 0.8300 | |
| T47DKBLUC | Unknown | Unknown | Selumetinib | MEK | MAPK | 12608.155 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0047 | -0.0152 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | Sirolimus | MTOR | MTOR | 7546.069 | uM | 1.33890 | 0.19564 | 0.2689 | 0.2537 | 0.3682 | 0.2972 | 0.8730 | 0.8806 | |
| T47DKBLUC | Unknown | Unknown | Torkinib | 15360.211 | uM | 0.00023 | 0.00037 | -0.1763 | -0.1097 | 0.4213 | 0.9138 | 0.9795 | 0.8772 | |||
| T47DKBLUC | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12608.169 | uM | 32.47840 | 78.52930 | -0.1504 | -1.0000 | 1.2443 | 0.1090 | 0.9911 | 1.2559 | |
| T47DKBLUC | Unknown | Unknown | Valproic acid | HDAC | HDAC | 12608.143 | uM | 588.1360 | 1000.00000 | -0.9427 | -0.5082 | 1.3212 | 0.2552 | 0.8479 | 1.1322 | |
| T47DKBLUC | Unknown | Unknown | Vorinostat | HDAC | HDAC | 7546.065 | uM | 54.73330 | 129.0020 | -0.9850 | -1.0000 | 1.2814 | 0.7914 | 0.9970 | 0.8300 | |
| T47DKBLUC | Unknown | Unknown | ZM-447439 | AURK | AURK | 12608.169 | uM | inf | inf | 0.9693 | 0.9693 | 0.0000 | 0.0194 | 0.0000 | 1.2559 | |
| HMT-3522 S1 | Unknown | Unknown | Carboplatin | DNA cross-linker | DNA cross-linker | 7911.011 | uM | 48.34180 | 57.48450 | -0.8108 | -0.6888 | 5.0000 | 0.3994 | 0.9880 | 1.6150 | |
| T47DKBLUC | Unknown | Unknown | XRP44X | ELK3 | MAPK | 12608.171 | uM | 1.87240 | 1.88460 | 0.0214 | -0.0164 | 5.0000 | 0.3781 | 0.9604 | 1.0643 | |
| T47DKBLUC | Unknown | Unknown | Vorinostat | HDAC | HDAC | 7544.065 | uM | 102.30620 | 173.99410 | -0.9372 | -0.9496 | 2.0044 | 0.7528 | 0.9920 | 1.2323 | |
| T47DKBLUC | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 7546.065 | uM | 2.24310 | 5.70120 | -0.9836 | -1.0000 | 1.1777 | 1.0735 | 0.9952 | 0.8300 | |
| T47DKBLUC | Unknown | Unknown | TPCA-1 | IKK | NFKB | 7544.093 | uM | inf | inf | 0.9073 | 0.9073 | 0.0000 | 0.0221 | 0.2623 | 1.2382 | |
| T47DKBLUC | Unknown | Unknown | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7546.067 | uM | 8.00270 | 9.96350 | -0.9936 | -0.9953 | 4.9989 | 0.3924 | 0.9975 | 0.8509 | |
| T47DKBLUC | Unknown | Unknown | Sigma A6730 | AKT | AKT | 12608.165 | uM | 4.44050 | 7.33420 | -0.1490 | -0.3047 | 0.9483 | 0.2875 | 0.9539 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | Purvalanol A | CDK1 | CDK | 7546.067 | uM | inf | 30.67960 | 0.7500 | 0.7500 | 4.9997 | 0.0111 | 0.8401 | 0.8509 |