Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7896.042 | uM | inf | inf | 0.9737 | 0.9737 | 0.0000 | -0.0276 | -0.7203 | 1.1632 | |
| MDA-MB-361 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 10095.034 | uM | 45.56020 | 1000.00000 | -0.6337 | -0.9350 | 0.3414 | 0.4082 | 0.6725 | 0.7874 | ||
| MDA-MB-361 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 10095.002 | uM | 0.00373 | 0.00429 | -0.0736 | -0.1027 | 1.3348 | 0.6771 | 0.9570 | 0.9451 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 7896.007 | uM | 10.35680 | 10.90870 | 0.0635 | -0.0319 | 1.1905 | 0.1510 | 0.9927 | 1.1203 | |
| MDA-MB-361 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10095.021 | uM | 8.16070 | 20.26560 | -0.7147 | -0.8241 | 1.0707 | 0.3702 | 0.9966 | 0.9164 | |
| BT-474 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 12056.144 | uM | 0.04627 | 3.88920 | -0.9770 | -1.0000 | 0.2479 | 0.6966 | 0.7390 | 0.9738 | |
| MDA-MB-361 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9648.017 | uM | 5.38310 | 9.04240 | -0.9575 | -0.8451 | 1.9080 | 0.4369 | 0.9907 | 0.5727 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 10095.034 | uM | 2.82210 | 2.77330 | -0.0254 | 0.0417 | 4.9987 | 0.2240 | 0.9841 | 0.7874 | |
| MDA-MB-361 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7896.017 | uM | 10.54390 | 22.08210 | -0.7591 | -0.8265 | 1.3199 | 0.3220 | 0.9968 | 1.0113 | |
| MDA-MB-361 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 7505.078 | uM | 42.41920 | 18.19230 | 0.4110 | 0.3099 | 1.1425 | 0.0907 | 0.9832 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | Disulfiram | Proteasome | Proteasome | 12989.174 | uM | 0.06115 | 0.07443 | -1.0000 | -0.4869 | 3.4592 | 0.7829 | 0.8122 | 0.7084 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 10643.146 | uM | 1.36050 | 1.50580 | -0.6287 | -0.3306 | 5.0000 | 0.3119 | 0.9352 | 0.6436 | |
| 600MPE | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 12224.144 | uM | 5.47790 | 75.42020 | -0.3435 | -1.0000 | 0.4189 | 0.3447 | 0.8258 | 1.0210 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 10999.155 | uM | inf | inf | 0.1363 | 0.1363 | 0.0000 | 0.3510 | 0.4641 | 0.7370 | |
| MDA-MB-361 | HER2amp | Luminal | Disulfiram | Proteasome | Proteasome | 13558.174 | uM | inf | inf | 0.4349 | 0.4349 | 0.0000 | 0.5249 | 0.5730 | 0.5699 | |
| MDA-MB-361 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 12379.155 | uM | 0.06506 | 0.11443 | -0.9594 | -0.9485 | 1.8838 | 0.8609 | 0.9969 | 0.3793 | |
| MDA-MB-361 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 12989.176 | uM | 21.01530 | 332.80780 | 0.6925 | -0.8609 | 0.3625 | 0.0677 | 0.8401 | 0.7997 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10999.151 | uM | inf | inf | 0.6771 | 0.6771 | 0.0000 | 0.0774 | 0.0387 | 0.7090 | |
| MDA-MB-361 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 7896.04 | uM | 0.04248 | 0.04988 | -0.6162 | -0.6169 | 5.0000 | 0.9131 | 0.9987 | 1.0776 | |
| MDA-MB-361 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 7508.074 | uM | 13.21680 | 20.82640 | -0.6749 | -0.6730 | 1.8752 | 0.3501 | 0.9965 | 0.7924 | |
| MDA-MB-361 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 7896.043 | uM | 4.09090 | 6.99190 | -0.5297 | -0.5851 | 1.4456 | 0.3427 | 0.9856 | 0.8553 | |
| MDA-MB-361 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 12989.002 | uM | 0.00679 | 0.00820 | -0.2712 | -0.2397 | 2.0828 | 0.6940 | 0.9982 | 0.6028 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 7848.001 | uM | 0.23168 | 2.21180 | -0.7395 | -1.0000 | 0.4869 | 0.5192 | 0.9120 | 0.4548 | |
| BT-474 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9163.026 | uM | inf | 0.00002 | 0.8122 | 0.8820 | 4.9564 | 0.0838 | 0.5768 | 0.3738 | |
| MDA-MB-361 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 7896.007 | uM | 0.21394 | 0.48965 | -0.9610 | -0.7252 | 1.0825 | 0.6704 | 0.9714 | 1.1203 |