Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 10264.026 | uM | inf | inf | 0.8544 | 0.8544 | 0.0000 | 0.0234 | 0.5438 | 1.5047 | |
| MDA-MB-436 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 10266.026 | uM | inf | inf | 0.7319 | 0.7319 | 0.0000 | 0.0071 | 0.5379 | 0.6682 | |
| MDA-MB-361 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9648.026 | uM | inf | 0.00320 | 0.3886 | 0.5402 | 1.5326 | 0.2764 | 0.8808 | 0.7065 | |
| LY2 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 10264.026 | uM | inf | inf | 0.9706 | 0.9706 | 0.0000 | -0.0006 | 0.1039 | 1.5047 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7808.052 | uM | inf | inf | 0.9944 | 0.9944 | 0.0000 | -0.0231 | -0.8225 | 2.4842 | |
| HCC1187 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7811.018 | uM | inf | inf | 0.6946 | 0.6946 | 0.0000 | 0.1308 | -0.0060 | 0.4694 | |
| HCC1187 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7812.042 | uM | inf | inf | 0.5614 | 0.5614 | 0.0000 | 0.0267 | 0.3674 | 0.9722 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9146.122 | uM | inf | inf | 0.9694 | 0.9694 | 0.0000 | -0.0404 | -1.9847 | 1.3408 | |
| MDA-MB-436 | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 10266.026 | uM | inf | inf | 0.0817 | 0.0817 | 0.0000 | 0.1773 | 0.3932 | 0.6682 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7793.018 | uM | inf | inf | 0.9318 | 0.9318 | 0.0000 | 0.0067 | 0.3477 | 1.3186 | |
| MDA-MB-157 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7879.018 | uM | inf | inf | 0.9952 | 0.9952 | 0.0000 | -0.0245 | -1.0109 | 1.7910 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9035.018 | uM | inf | inf | 0.9083 | 0.9083 | 0.0000 | 0.0297 | 0.4162 | 2.1555 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7794.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.6812 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7807.042 | uM | inf | inf | 1.0098 | 1.0098 | 0.0000 | -0.0392 | -7.7987 | 2.0250 | |
| HCC38 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 9469.026 | uM | inf | inf | 0.8847 | 0.8847 | 0.0000 | 0.0250 | 0.5685 | 1.2092 | |
| MCF7 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9583.026 | uM | inf | inf | 0.9966 | 0.9966 | 0.0000 | 0.0156 | -0.0344 | 1.2731 | |
| HCC1143 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 9233.124 | uM | 0.71405 | 0.79473 | 0.5278 | -0.1473 | 2.4126 | 0.0082 | 0.9191 | 0.9990 | |
| SUM185PE | TNBC | Luminal | Trastuzumab | HER2 | ErbB | 10146.124 | uM | inf | inf | 0.8709 | 0.8709 | 0.0000 | -0.0388 | 0.2980 | 0.9296 | |
| MCF 10F | NM | - | Cetuximab | EGFR | ErbB | 7487.102 | uM | 1.06250 | 14.53060 | 0.5584 | -1.0000 | 0.4200 | 0.0918 | 0.9670 | 1.5273 | |
| MDA-MB-231 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7893.042 | uM | inf | inf | 0.7448 | 0.7448 | 0.0000 | 0.0660 | 0.1733 | 2.2789 | |
| MCF12A | NM | Basal B | Pertuzumab | 7489.102 | mg/ml | inf | 125.00000 | 0.8728 | 0.5007 | 0.2455 | 0.0447 | 0.7417 | 2.4234 | |||
| MCF 10F | NM | - | Cetuximab | EGFR | ErbB | 9566.026 | uM | inf | 0.82410 | 0.8674 | 0.5338 | 5.0000 | -0.0169 | 0.5906 | 2.1367 | |
| MCF 10F | NM | - | Cetuximab | EGFR | ErbB | 7872.042 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0054 | -0.0002 | 1.3632 | |
| BT-20 | TNBC | Basal A | Pertuzumab | 5903.102 | mg/ml | inf | inf | 0.9324 | 0.9324 | 0.0000 | -0.0074 | -0.0405 | 1.2557 | |||
| MCF 10A | NM | Basal B | Cetuximab | EGFR | ErbB | 9551.026 | uM | inf | 0.14350 | 0.7282 | 0.7281 | 4.9914 | 0.0090 | 0.9280 | 2.6508 |