Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 10379.066 | uM | inf | 8.96430 | 0.9086 | 0.9084 | 4.5819 | 0.0097 | 0.5911 | 2.3931 | |
| HCC3153 | TNBC | Basal A | AG1024 | IGF1R | RTK | 7465.066 | uM | 62.07240 | 384.31460 | 0.6227 | -0.9619 | 0.5885 | 0.0629 | 0.7553 | 1.2627 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 7471.066 | uM | inf | inf | 0.9596 | 0.9596 | 0.0000 | 0.0065 | 0.3052 | 2.2865 | |
| T47DKBLUC | Unknown | Unknown | AG1024 | IGF1R | RTK | 7545.066 | uM | 63.33250 | 593.94780 | 0.6104 | -0.9999 | 0.4908 | 0.0992 | 0.6267 | 1.2546 | |
| SUM229PE | TNBC | - | AG1024 | IGF1R | RTK | 7535.066 | uM | 5.15860 | 4.60680 | 0.2165 | 0.2160 | 5.0000 | 0.1733 | 0.9238 | 0.7812 | |
| SUM229PE | TNBC | - | AG1024 | IGF1R | RTK | 7537.066 | uM | 26.08790 | 6.20780 | 0.4820 | 0.3992 | 1.1154 | 0.1176 | 0.9213 | 2.0549 | |
| SUM225CWN | HER2amp | Basal A | AG1024 | IGF1R | RTK | 7534.066 | uM | 7.97910 | 4.70390 | 0.3051 | 0.2458 | 1.2803 | 0.1265 | 0.9847 | 1.0191 | |
| SUM225CWN | HER2amp | Basal A | AG1024 | IGF1R | RTK | 7533.066 | uM | 6.97750 | 6.8250 | 0.0527 | 0.0523 | 5.0000 | 0.1191 | 0.9671 | 0.8676 | |
| SUM185PE | TNBC | Luminal | AG1024 | IGF1R | RTK | 7532.066 | uM | 2.07550 | 9.85170 | -0.3983 | -1.0000 | 0.7054 | 0.3126 | 0.9683 | 0.9011 | |
| SUM159PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 7531.066 | uM | inf | inf | 1.0194 | 1.0194 | 0.0000 | -0.0256 | -1.3735 | 3.3129 | |
| SUM149PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 7530.066 | uM | inf | 11.32170 | 0.5974 | 0.5039 | 1.3545 | 0.0429 | 0.9508 | 1.9710 | |
| MDA-MB-436 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7902.016 | uM | 43.3210 | 43.06220 | 0.0159 | 0.0147 | 4.9808 | 0.1679 | 0.7461 | 1.9004 | |
| HCC1954 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 7836.016 | uM | 3.92550 | 41.26260 | -0.3725 | -1.0000 | 0.4670 | 0.3500 | 0.9742 | 1.5669 | |
| HCC1187 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7811.044 | uM | inf | inf | 0.9811 | 0.9811 | 0.0000 | 0.0159 | -0.0256 | 0.3073 | |
| HCC1954 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 7839.016 | uM | 3.43060 | 13.99720 | -0.0508 | -0.3477 | 0.3754 | 0.3413 | 0.8640 | 1.5556 | |
| MDA-MB-436 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7898.016 | uM | inf | inf | 0.7881 | 0.7881 | 0.0000 | 0.0310 | 0.3510 | 1.2127 | |
| HCC1954 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 7837.016 | uM | 0.77445 | 0.10184 | 0.2300 | 0.3001 | 0.4519 | 0.3972 | 0.6349 | 1.8067 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7878.016 | uM | inf | inf | 0.8526 | 0.8526 | 0.0000 | 0.0384 | 0.5269 | 1.4153 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7882.016 | uM | 11.29980 | 11.78750 | -0.2448 | -0.1176 | 5.0000 | 0.2809 | 0.9469 | 1.0905 | |
| SUM1315MO2 | TNBC | Basal B | AG1478 | EGFR | ErbB | 9797.019 | uM | 0.10528 | 0.10394 | -0.0189 | 0.0063 | 0.9966 | 0.5854 | 0.9663 | 0.4912 | |
| HCC1187 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7812.016 | uM | inf | 0.03633 | 0.7129 | 0.7912 | 4.9997 | 0.1273 | 0.8061 | 1.0628 | |
| SUM1315MO2 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7529.016 | uM | 2.96190 | 3.04390 | 0.0087 | -0.0072 | 0.5268 | 0.3345 | 0.9160 | 0.5847 | |
| HBL-100 | Unknown | Unknown | AG1478 | EGFR | ErbB | 7808.016 | uM | inf | inf | 0.9515 | 0.9515 | 0.0000 | -0.0168 | 0.0597 | 2.2401 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 7824.016 | uM | 6.10490 | 12.64480 | -0.1925 | -0.3733 | 0.7659 | 0.3219 | 0.9839 | 1.7164 | |
| HCC1428 | HR+ | Luminal | AG1478 | EGFR | ErbB | 9294.019 | uM | inf | 0.34423 | 0.7436 | 0.6535 | 4.9996 | 0.1885 | 0.6201 | 0.8608 |