Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | 5-FU | TYMS | TYMS | 9294.017 | uM | 6.17330 | 16.50340 | -0.7904 | -0.7842 | 0.9593 | 1.0530 | 0.8821 | 0.8160 | |
| MCF12A | NM | Basal B | 5-DFUR | TYMS | TYMS | 12365.143 | uM | 22.40880 | 268.29440 | -0.6111 | -1.0000 | 0.4425 | 0.5407 | 0.9913 | 2.3865 | |
| LY2 | HR+ | Luminal | 5-FU | TYMS | TYMS | 7865.017 | uM | 9.53280 | 35.8810 | -0.6181 | -0.6912 | 0.6549 | 0.8556 | 0.9694 | 1.9138 | |
| BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 10581.143 | uM | 180.72220 | 1000.00000 | -0.1731 | -0.6881 | 0.5059 | 0.3625 | 0.8258 | 0.9062 | |
| MDA-MB-468 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7906.017 | uM | 470.6870 | 581.98590 | -0.9702 | -0.9450 | 5.0000 | 0.5412 | 0.9967 | 0.3822 | |
| MDA-MB-468 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7904.017 | uM | 189.18420 | 283.16380 | -0.2286 | -0.2563 | 1.0261 | 0.4171 | 0.9852 | 1.4023 | |
| BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 11854.143 | uM | 402.01920 | 550.84780 | 0.1316 | -0.1064 | 0.6126 | 0.2317 | 0.9890 | 1.1185 | |
| BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 12056.143 | uM | 322.2530 | 1000.00000 | 0.0366 | -0.3258 | 0.4431 | 0.2795 | 0.9185 | 1.0075 | |
| MDA-MB-468 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7907.017 | uM | 127.80370 | 331.63740 | -0.5890 | -0.5993 | 0.8262 | 0.5160 | 0.9824 | 1.4157 | |
| MDA-MB-468 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7909.13 | uM | 296.96450 | 411.31820 | -0.3300 | -0.2753 | 1.3467 | 0.3890 | 0.9663 | 1.5270 | |
| LY2 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 10816.143 | uM | 8.28680 | 13.63060 | -0.9893 | -0.9266 | 2.1068 | 0.8679 | 0.9929 | 0.4975 | |
| HCC2185 | TNBC | Luminal | 5-FU | TYMS | TYMS | 7849.017 | uM | 532.52940 | 619.620 | -0.6891 | -0.5663 | 5.0000 | 0.3976 | 0.990 | 0.3471 | |
| LY2 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 12319.143 | uM | 0.45281 | 3.81640 | -0.9874 | -1.0000 | 0.5154 | 1.1295 | 0.8727 | 0.5178 | |
| LY2 | HR+ | Luminal | 5-FU | TYMS | TYMS | 10264.131 | uM | 45.54210 | 231.48110 | -0.5236 | -0.7162 | 0.5467 | 0.6044 | 0.9825 | 1.4548 | |
| LY2 | HR+ | Luminal | 5-FU | TYMS | TYMS | 9536.017 | uM | 84.57250 | 544.07170 | -0.6885 | -0.9953 | 0.5885 | 0.5950 | 0.9801 | 1.4526 | |
| BT-474 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 12178.143 | uM | 1053.93470 | 690.84680 | 0.2785 | 0.1751 | 1.0203 | 0.1699 | 0.9078 | 0.7617 | |
| MCF12A | NM | Basal B | 5-DFUR | TYMS | TYMS | 10817.143 | uM | 25.65560 | 213.55380 | -0.8227 | -1.0000 | 0.5184 | 0.5449 | 0.9767 | 1.5734 | |
| HCC1143 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7809.017 | uM | 623.11290 | 167.76560 | 0.2797 | 0.2268 | 0.4605 | 0.3087 | 0.9302 | 1.7591 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7793.035 | uM | 7.14650 | 49.68870 | -0.3950 | -0.5513 | 0.3832 | 0.7305 | 0.9781 | 1.2119 | |
| HCC1937 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 11849.143 | uM | 475.98340 | 554.27760 | 0.0804 | -0.0680 | 0.8376 | 0.1832 | 0.9881 | 1.3433 | |
| HCC70 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 10873.143 | uM | 200.95550 | 1000.00000 | -0.1837 | -0.6154 | 0.5000 | 0.2961 | 0.9812 | 1.2785 | |
| HMT-3522 S1 | Unknown | Unknown | 5-FU | TYMS | TYMS | 7911.017 | uM | 171.27690 | 862.56090 | -0.4058 | -0.7064 | 0.5448 | 0.4588 | 0.9804 | 1.6151 | |
| 184A1 | NM | Basal | 5-DFUR | TYMS | TYMS | 12509.143 | uM | 228.63720 | 1000.00000 | -0.2404 | -0.6424 | 0.5600 | 0.2642 | 0.9697 | 1.3392 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 12523.143 | uM | 445.02050 | 1000.00000 | 0.1011 | -0.2057 | 0.4255 | 0.2304 | 0.9370 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 10872.143 | uM | 377.42770 | 1000.00000 | 0.0754 | -0.3195 | 0.5071 | 0.2513 | 0.9868 | 1.6364 |