Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11057.154 | uM | 0.93514 | 4.6160 | -0.7352 | -1.0000 | 0.6881 | 0.3694 | 0.9808 | 3.8498 | |
| SUM159PT | TNBC | Basal B | LBH589 | HDAC | HDAC | 11057.154 | uM | 0.24013 | 0.40952 | -0.7352 | -0.7529 | 1.7208 | 0.6122 | 0.9965 | 3.8498 | |
| SUM159PT | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 11057.152 | uM | 1.15310 | 1.13690 | 0.0039 | 0.0251 | 3.6451 | 0.2485 | 0.9981 | 3.8541 | |
| SUM159PT | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 11057.152 | uM | 2.59470 | 3.4840 | -0.7348 | -0.5153 | 2.4037 | 0.4415 | 0.9745 | 3.8541 | |
| SUM159PT | TNBC | Basal B | PD 98059 | MEK | MAPK | 11057.152 | uM | 172.25410 | 634.23160 | 0.7857 | -0.9988 | 0.8422 | 0.0305 | 0.8640 | 3.8541 | |
| SUM159PT | TNBC | Basal B | Sigma A6730 | AKT | AKT | 11057.158 | uM | 11.04450 | 21.67290 | -0.7343 | -1.0000 | 1.6297 | 0.2053 | 0.9975 | 3.8594 | |
| SUM159PT | TNBC | Basal B | AS-252424 | PI3K | PI3K | 11057.158 | uM | inf | 3.06690 | 0.4735 | 0.5788 | 5.0000 | 0.0928 | 0.9104 | 3.8594 | |
| SUM159PT | TNBC | Basal B | Afatinib | EGFR/HER2 | ErbB | 11057.158 | uM | 3.9340 | 7.18480 | -0.7343 | -0.7885 | 1.5717 | 0.3293 | 0.9976 | 3.8594 | |
| SUM159PT | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 11057.135 | uM | inf | 30.93790 | 0.6673 | 0.6670 | 4.9977 | 0.0270 | 0.9663 | 3.9340 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 11057.135 | uM | 1.28990 | 0.96672 | 0.1560 | 0.1358 | 1.0990 | 0.2860 | 0.9973 | 3.9340 | |
| SUM159PT | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 11057.147 | uM | 7.28880 | 6.97660 | 0.0532 | 0.0438 | 2.0939 | 0.2366 | 0.9949 | 3.9818 | |
| SUM159PT | TNBC | Basal B | NU6102 | CDK1/2 | CDK | 11057.147 | uM | 17.1090 | 24.21920 | -0.1545 | -0.3781 | 1.6205 | 0.1481 | 0.9919 | 3.9818 | |
| SUM159PT | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 11057.147 | uM | 0.84250 | 4.57980 | -0.7232 | -1.0000 | 0.6489 | 0.4577 | 0.9988 | 3.9818 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11057.15 | uM | 2.65110 | 41.24140 | 0.0213 | -0.9986 | 0.4000 | 0.2444 | 0.9757 | 4.0042 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 11057.15 | uM | inf | 0.43340 | 0.6315 | 0.6227 | 5.0000 | 0.1138 | 0.9875 | 4.0042 | |
| SUM159PT | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 11057.15 | uM | inf | 1.87160 | 0.6613 | 0.6691 | 2.5283 | 0.0649 | 0.9799 | 4.0042 | ||
| SUM159PT | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 11057.072 | uM | 240.88130 | 167.67830 | 0.6604 | 0.3171 | 2.7765 | 0.0050 | 0.9563 | 4.0230 | |
| SUM159PT | TNBC | Basal B | Sulindac sulfide | COX1/2 | COX | 10520.136 | uM | inf | inf | 0.9767 | 0.9767 | 0.0000 | -0.0015 | 0.0597 | 4.0331 | |
| SUM159PT | TNBC | Basal B | Celecoxib | COX2 | COX | 10520.136 | uM | inf | inf | 0.9370 | 0.9370 | 0.0000 | 0.0170 | 0.1158 | 4.0331 | |
| SUM159PT | TNBC | Basal B | PD 98059 | MEK | MAPK | 10520.136 | uM | inf | 60.9410 | 0.7037 | 0.5045 | 0.8153 | 0.0356 | 0.8909 | 4.0331 | |
| SUM159PT | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 11057.149 | uM | 138.43220 | 340.81150 | 0.7733 | -0.4654 | 0.7303 | 0.0467 | 0.7551 | 4.1019 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 11057.149 | uM | 29.35970 | 49.41790 | 0.4099 | -0.8250 | 1.8716 | 0.0368 | 0.9824 | 4.1019 | |
| SUM159PT | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 11057.143 | uM | 117.49380 | 138.80550 | 0.0197 | -0.0551 | 0.6266 | 0.3060 | 0.9924 | 4.1426 | |
| SUM159PT | TNBC | Basal B | Ibandronate | FDPS | 11057.143 | uM | 98.76930 | 55.29940 | 0.2436 | 0.2680 | 1.3241 | 0.1795 | 0.9859 | 4.1426 | ||
| SUM159PT | TNBC | Basal B | Valproic acid | HDAC | HDAC | 11057.143 | uM | 761.54820 | 1000.00000 | -0.5710 | -0.1965 | 1.2168 | 0.2071 | 0.8155 | 4.1426 |