Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 10520.135 | uM | 97.22130 | 40.41170 | 0.4897 | 0.4856 | 4.0427 | 0.0293 | 0.9568 | 3.6895 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 10520.135 | uM | 0.79624 | 0.86326 | -0.0471 | -0.0481 | 1.1374 | 0.3389 | 0.9955 | 3.6895 | |
| SUM159PT | TNBC | Basal B | Chk2 inhibitor II | CHK2 | CHK | 10520.14 | uM | inf | inf | 0.9128 | 0.9128 | 0.0000 | 0.0580 | 0.4027 | 3.7031 | |
| SUM159PT | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 10520.14 | uM | 0.48877 | 0.61898 | -0.3612 | -0.3328 | 2.1599 | 0.4285 | 0.9923 | 3.7031 | |
| SUM159PT | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 10520.14 | uM | 1.48650 | 1.72640 | -0.7051 | -0.5565 | 5.0000 | 0.5214 | 0.9692 | 3.7031 | |
| SUM159PT | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7919.042 | uM | 0.01028 | 0.01106 | -0.3868 | -0.1639 | 3.8975 | 0.7505 | 0.9702 | 3.7203 | |
| SUM159PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7919.042 | uM | inf | 4.91520 | 0.9535 | 0.7757 | 0.6890 | 0.0060 | 0.8149 | 3.7203 | |
| SUM159PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7919.04 | uM | 0.04167 | 0.05119 | -0.4725 | -0.2657 | 2.0719 | 0.7284 | 0.9791 | 3.7375 | |
| SUM159PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 7919.04 | uM | 0.00594 | 0.00689 | -0.2375 | -0.2460 | 2.7121 | 0.9268 | 0.9992 | 3.7375 | |
| MCF 10A | NM | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7485.067 | uM | 5.35070 | 8.22830 | -0.4965 | -0.5259 | 1.6702 | 0.3809 | 0.9972 | 3.7597 | |
| MCF 10A | NM | Basal B | Purvalanol A | CDK1 | CDK | 7485.067 | uM | inf | 1000.00000 | 0.8943 | 0.7817 | 0.1323 | 0.0582 | 0.6910 | 3.7597 | |
| MCF 10A | NM | Basal B | Ispinesib | KSP | Kinesin | 7485.067 | uM | 0.14987 | 1.80190 | -0.4694 | -0.8167 | 0.3894 | 0.4872 | 0.9420 | 3.7597 | |
| SUM159PT | TNBC | Basal B | Temsirolimus | MTOR | MTOR | 11057.144 | uM | 3.51290 | 26.67560 | -0.7417 | -1.0000 | 0.5419 | 0.4064 | 0.8413 | 3.7784 | |
| SUM159PT | TNBC | Basal B | SB-3CT | MMP2/9 | MMP | 11057.144 | uM | 22.69590 | 50.71310 | -0.4344 | -1.0000 | 1.3664 | 0.1434 | 0.9948 | 3.7784 | |
| SUM159PT | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 11057.144 | uM | 14.15840 | 170.79050 | -0.1209 | -1.0000 | 0.4412 | 0.2119 | 0.8005 | 3.7784 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 10520.137 | uM | 18.60730 | 49.81870 | 0.2133 | -1.0000 | 1.1155 | 0.1476 | 0.8304 | 3.7823 | |
| SUM159PT | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 10520.137 | uM | inf | inf | 0.8283 | 0.8283 | 0.0000 | 0.0670 | 0.5419 | 3.7823 | |
| SUM159PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 7919.017 | uM | 68.19810 | 71.10910 | -0.0335 | -0.0155 | 0.7291 | 0.4298 | 0.9904 | 3.7958 | |
| SUM159PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7919.017 | uM | 3.87590 | 6.04680 | -0.5573 | -0.4798 | 1.5126 | 0.4101 | 0.9928 | 3.7958 | |
| SUM159PT | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7919.017 | uM | 0.18887 | 0.25521 | -0.6913 | -0.3973 | 1.9428 | 0.6797 | 0.9592 | 3.7958 | |
| SUM159PT | TNBC | Basal B | Bosutinib | Src | nRTK | 11057.145 | uM | 3.35180 | 5.16640 | -0.6605 | -0.6816 | 1.9876 | 0.4174 | 0.9853 | 3.8266 | |
| SUM159PT | TNBC | Basal B | Nilotinib | ABL | nRTK | 11057.145 | uM | inf | inf | 1.0062 | 1.0062 | 0.0000 | -0.0143 | -0.1841 | 3.8266 | |
| SUM159PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 11057.145 | uM | 0.05731 | 0.07460 | -0.7373 | -0.5011 | 2.6315 | 0.7726 | 0.9669 | 3.8266 | |
| SUM159PT | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 11057.145 | uM | 0.05731 | 0.07460 | -0.7373 | -0.5011 | 2.6315 | 0.7726 | 0.9669 | 3.8266 | |
| SUM159PT | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 11057.154 | uM | 8.08130 | 9.68710 | -0.5505 | -0.5595 | 4.1437 | 0.1410 | 0.9976 | 3.8498 |