Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | XRP44X | ELK3 | MAPK | 12305.157 | uM | 1.46020 | 1.22050 | 0.2279 | 0.2960 | 5.0000 | 0.3010 | 0.9051 | 2.9955 | |
| BT-549 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7803.011 | uM | 33.04150 | 53.67520 | -0.6366 | -0.6683 | 1.7492 | 0.4207 | 0.9973 | 3.0094 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7803.011 | uM | 0.00759 | 0.00979 | -0.2571 | -0.2190 | 1.4280 | 0.9010 | 0.9933 | 3.0094 | |
| BT-549 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7803.011 | uM | 2.02090 | 6.22230 | -0.7341 | -0.7799 | 0.8358 | 0.6413 | 0.9903 | 3.0094 | |
| BT-549 | TNBC | Basal B | GM6001 | MMP | MMP | 5909.096 | uM | inf | 5.95550 | 0.8966 | 0.8697 | 0.7287 | 0.0248 | 0.7038 | 3.0117 | |
| BT-549 | TNBC | Basal B | QNZ | NFkB | NFKB | 5909.096 | uM | inf | 0.01255 | 0.7939 | 0.8094 | 0.8368 | 0.1153 | 0.8079 | 3.0117 | |
| BT-549 | TNBC | Basal B | TAPI-0 | TACE/Collagenase | 5909.096 | uM | inf | 4.6090 | 0.8816 | 0.8803 | 2.2975 | 0.0095 | 0.7446 | 3.0117 | ||
| MCF 10A | NM | Basal B | Methylglyoxal | 13551.184 | uM | 680.90370 | 999.99950 | -0.2926 | -0.2104 | 0.9138 | 0.3902 | 0.9470 | 3.0171 | |||
| MCF 10A | NM | Basal B | ZM-447439 | AURK | AURK | 11056.15 | uM | inf | 0.46426 | 0.6809 | 0.6831 | 2.5666 | 0.1026 | 0.9909 | 3.0207 | |
| MCF 10A | NM | Basal B | Glycyl-H-1152 | ROCK2 | 11056.15 | uM | inf | 2.34330 | 0.5757 | 0.5710 | 2.1336 | 0.0938 | 0.9859 | 3.0207 | ||
| MCF 10A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11056.15 | uM | 4.25490 | 9.16210 | 0.2253 | -0.1815 | 0.4037 | 0.2101 | 0.9544 | 3.0207 | |
| SUM159PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7918.018 | uM | inf | inf | 0.9278 | 0.9278 | 0.0000 | 0.0321 | 0.1456 | 3.0213 | |
| SUM159PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7918.018 | uM | 113.81230 | 620.84460 | -0.5727 | -1.0000 | 0.6476 | 0.4014 | 0.9793 | 3.0213 | ||
| SUM159PT | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7918.018 | uM | 0.00074 | 0.00109 | -0.5523 | -0.3456 | 1.3735 | 1.1044 | 0.9653 | 3.0213 | |
| BT-549 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14122.189 | uM | 0.14922 | 0.16636 | -0.8306 | -0.3612 | 5.0000 | 0.6812 | 0.6090 | 3.0232 | |
| BT-549 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14122.189 | uM | 0.14922 | 0.16636 | -0.8306 | -0.3612 | 5.0000 | 0.6812 | 0.6090 | 3.0232 | |
| BT-549 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14122.189 | uM | 0.44048 | 0.52843 | -0.7285 | -0.7424 | 5.0000 | 0.6618 | 0.9973 | 3.0232 | |
| MCF 10A | NM | Basal B | ICRF-193 | TOP2 | TOP | 11056.151 | uM | inf | 0.04801 | 0.5349 | 0.5474 | 2.0247 | 0.2393 | 0.9850 | 3.0292 | |
| MCF 10A | NM | Basal B | XRP44X | ELK3 | MAPK | 11056.151 | uM | 0.35713 | 0.35089 | 0.0205 | 0.0422 | 5.0000 | 0.4286 | 0.9989 | 3.0292 | |
| BT-549 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 5909.092 | uM | 64.86970 | 405.03060 | 0.6245 | -0.9999 | 0.5998 | 0.0549 | 0.9591 | 3.0314 | |
| BT-549 | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 5909.092 | uM | 5.07990 | 6.30740 | -0.7169 | -0.7170 | 4.1102 | 0.3216 | 0.9990 | 3.0314 | |
| BT-549 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 5909.092 | uM | 36.52830 | 49.83120 | -0.7507 | -0.7525 | 2.9569 | 0.3310 | 0.9990 | 3.0314 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 5909.066 | uM | inf | inf | 0.9667 | 0.9667 | 0.0000 | -0.0279 | -0.7876 | 3.0464 | |
| BT-549 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 5909.066 | uM | inf | 34.75420 | 0.6171 | 0.5024 | 1.8452 | 0.0287 | 0.9686 | 3.0464 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 7483.091 | uM | 5.84960 | 6.37170 | -0.4695 | -0.2667 | 5.0000 | 0.3192 | 0.9527 | 3.0465 |