Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 10077.026 | uM | 7.0350 | 7.93710 | 0.4622 | -0.4084 | 4.9480 | -0.0133 | 0.9348 | 0.3999 | |
| HCC1395 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9258.03 | uM | 607.47860 | 1000.00000 | -0.8573 | -0.7154 | 1.7821 | 0.3361 | 0.9845 | 0.4015 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9258.03 | uM | 1.05110 | 2.06760 | -1.0000 | -1.0000 | 1.6238 | 0.7227 | 0.9985 | 0.4015 | |
| HCC1395 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9258.03 | uM | 0.05903 | 0.23991 | -0.6420 | -0.5382 | 0.5211 | 0.7273 | 0.9026 | 0.4015 | |
| HCC1419 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 7437.067 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0473 | -48.7760 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7437.067 | uM | inf | inf | -0.9973 | -0.9973 | 0.0000 | 0.2089 | 0.4251 | 0.4038 | |
| HCC1419 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 7437.067 | uM | 7.18670 | 9.59040 | -1.0000 | -1.0000 | 3.8076 | 0.2622 | 0.9186 | 0.4038 | |
| SUM185PE | TNBC | Luminal | Everolimus | MTOR | MTOR | 12269.164 | uM | 4.14390 | 6.9690 | -0.6978 | -0.7338 | 1.7375 | 0.4199 | 0.7167 | 0.4042 | |
| SUM1315MO2 | TNBC | Basal B | Taxol | TUBB | TUBB | 9797.002 | uM | 0.00284 | 0.00504 | -0.9455 | -0.9308 | 1.8346 | 1.3072 | 0.9984 | 0.4052 | |
| SUM1315MO2 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9797.002 | uM | 0.00077 | 0.00224 | -0.9724 | -0.9777 | 1.0171 | 1.2866 | 0.9990 | 0.4052 | |
| MDA-MB-175-VII | HR+ | Luminal | AS-252424 | PI3K | PI3K | 10642.141 | uM | 1.67410 | 6.99740 | -0.8954 | -1.0000 | 0.7681 | 0.3930 | 0.9743 | 0.4059 | |
| MDA-MB-175-VII | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10642.141 | uM | 1.68880 | 3.46820 | -0.9963 | -1.0000 | 1.5267 | 0.5003 | 0.9904 | 0.4059 | |
| UACC-812 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 10150.002 | uM | 0.00201 | 0.00235 | -0.0289 | -0.1601 | 1.7981 | 0.7583 | 0.9645 | 0.4064 | |
| UACC-812 | HER2amp | Luminal | Taxol | TUBB | TUBB | 10150.002 | uM | 0.00749 | 0.00833 | -0.4274 | -0.3478 | 5.0000 | 0.8685 | 0.9919 | 0.4064 | |
| T47D | HR+ | Luminal | Taxol | TUBB | TUBB | 9897.002 | uM | 0.00762 | 0.00898 | -0.6614 | -0.6336 | 5.0000 | 1.0525 | 0.9987 | 0.4068 | |
| T47D | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9897.002 | uM | 0.00256 | 0.00296 | -0.5189 | -0.5430 | 4.9999 | 0.9824 | 0.9806 | 0.4068 | |
| UACC-812 | HER2amp | Luminal | Taxol | TUBB | TUBB | 10267.002 | uM | 0.00511 | 0.00565 | -0.4735 | -0.3262 | 5.0000 | 0.8803 | 0.9892 | 0.4069 | |
| UACC-812 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 10267.002 | uM | 0.00408 | 0.00445 | -0.2526 | -0.2764 | 5.0000 | 0.7526 | 0.9798 | 0.4069 | |
| HCC1187 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 13726.176 | uM | inf | inf | 0.6786 | 0.6786 | 0.0000 | 0.3517 | -0.3654 | 0.4071 | |
| HCC1419 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 7440.066 | uM | inf | inf | 0.7221 | 0.7221 | 0.0000 | 0.0385 | 0.4442 | 0.4073 | |
| HCC1419 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 7440.066 | uM | inf | 16.58670 | 0.5399 | 0.5395 | 4.9875 | 0.0695 | 0.7841 | 0.4073 | |
| SUM52PE | HR+ | Luminal | Dichloroacetate | PDK | PDK | 13570.176 | uM | inf | inf | 0.7219 | 0.7219 | 0.0000 | 0.3099 | 0.0434 | 0.4076 | |
| SUM1315MO2 | TNBC | Basal B | Ribavirin | 15401.211 | uM | inf | inf | 0.9740 | 0.9740 | 0.0000 | 0.0925 | 0.0630 | 0.4079 | |||
| SUM1315MO2 | TNBC | Basal B | Torkinib | 15401.211 | uM | -inf | 0.00012 | -0.9603 | -0.8964 | 0.4331 | 1.6631 | 0.9588 | 0.4079 | |||
| BT-474 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9158.049 | uM | 0.00737 | 0.00871 | -0.8389 | -0.6523 | 5.0000 | 1.1719 | 0.9370 | 0.4082 |