Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
184A1	NM	Basal	PD184352	MEK	MAPK	12509.155	uM	8.55920	48.2470	0.1172	-1.0000	0.6353	0.1432	0.9509	1.3444
184A1	NM	Basal	PD184352	MEK	MAPK	12509.155	uM	8.55920	48.2470	0.1172	-1.0000	0.6353	0.1432	0.9509	1.3444
184A1	NM	Basal	GSK461364	PLK1	PLK	9047.001	uM	4.15810	52.44110	-0.0073	-1.0000	0.4334	0.2620	0.7464	0.7701
184A1	NM	Basal	GSK461364	PLK1	PLK	10002.001	uM	6.06620	9.11620	-0.9717	-1.0000	2.6972	0.2605	0.9735	0.5372
184B5	NM	Basal	Etoposide	TOP2	TOP	5896.074	uM	4.08810	48.86320	-0.4513	-1.0000	0.4428	0.4398	0.9738	1.4124
184A1	NM	Basal	GSK923295	CENPE	Kinesin	10002.001	uM	8.47170	11.6240	-0.9507	-1.0000	3.4729	0.2407	0.9439	0.5372
184A1	NM	Basal	Sigma A6730	AKT	AKT	12509.165	uM	3.14240	13.05610	-0.6553	-1.0000	0.7714	0.3161	0.9885	1.5022
184A1	NM	Basal	Ibandronate	FDPS		12509.143	uM	155.22840	288.34070	-0.9140	-1.0000	1.7741	0.2785	0.9964	1.3392
184A1	NM	Basal	Everolimus	MTOR	MTOR	12509.164	uM	0.02317	2.80470	-0.9610	-1.0000	0.2291	0.6861	0.6516	1.1949
184A1	NM	Basal	IKK16	IKK	NFKB	5895.093	uM	1.01110	2.37210	-0.9564	-1.0000	1.2884	0.5085	0.9882	1.3259
184A1	NM	Basal	Imatinib	ABL/KIT/PDGFR	nRTK	5895.091	uM	16.09010	26.49230	-0.9899	-1.0000	2.2032	0.4630	0.9969	1.1729
184A1	NM	Basal	Ispinesib	KSP	Kinesin	5894.067	uM	1.62180	3.48940	-0.9288	-1.0000	1.4339	0.3983	0.9581	1.5647
184A1	NM	Basal	Ispinesib	KSP	Kinesin	5895.067	uM	2.25070	4.57410	-0.9091	-1.0000	1.5491	0.3497	0.9692	1.4053
184A1	NM	Basal	Ixabepilone	TUBB	TUBB	5895.095	uM	0.14338	0.76637	-0.9501	-1.0000	0.6554	0.6829	0.9483	1.4629
184B5	NM	Basal	GSK923295	CENPE	Kinesin	9095.001	uM	1.82040	10.84810	-0.6893	-1.0000	0.6155	0.3102	0.7760	1.0444
184A1	NM	Basal	Oxaliplatin	DNA cross-linker	DNA cross-linker	9047.011	uM	0.53932	2.18460	-0.9996	-1.0000	0.7854	0.8887	0.9928	0.6293
184A1	NM	Basal	L-779450	BRAF	MAPK	12509.166	uM	8.56520	14.40640	-0.7107	-1.0000	2.1129	0.1672	0.9687	1.2847
184A1	NM	Basal	Nutlin 3a	MDM2	MDM2	5894.066	uM	6.76640	16.58460	-0.8949	-1.0000	1.2254	0.2778	0.9387	1.5027
184B5	NM	Basal	GSK1838705A	IGF1R	RTK	5897.091	uM	2.5180	9.36910	-0.9343	-1.0000	0.8361	0.4350	0.9858	1.2296
184B5	NM	Basal	AS-252424	PI3K	PI3K	12566.165	uM	26.52190	125.8320	0.4159	-1.0000	0.7056	0.0982	0.8944	1.7248
184A1	NM	Basal	Etoposide	TOP2	TOP	5894.074	uM	9.28560	35.69030	-0.7680	-1.0000	0.8160	0.4044	0.9826	1.4541
184B5	NM	Basal	Temsirolimus	MTOR	MTOR	12566.168	uM	31.79770	47.19180	-0.9110	-1.0000	2.7825	0.3358	0.8544	1.4366
184A1	NM	Basal	Etoposide	TOP2	TOP	5895.074	uM	10.48650	42.19930	-0.7395	-1.0000	0.7891	0.3710	0.9859	1.1218
600MPE	HR+	Luminal	IKK16	IKK	NFKB	5898.093	uM	4.19220	5.22240	-0.9978	-1.0000	5.0000	0.4738	0.9724	0.6963
600MPE	HR+	Luminal	GSK461364	PLK1	PLK	9120.001	uM	10.38820	12.94090	-0.9973	-1.0000	5.0000	0.2756	0.7682	0.6180

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Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)