Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | Nilotinib | ABL | nRTK | 12428.17 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0450 | -2.6385 | 0.9724 | |
| MB 157 | Unknown | Unknown | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7482.084 | uM | inf | inf | 1.0106 | 1.0106 | 0.0000 | -0.0449 | -13.5536 | 1.8697 | |
| Hs 578T | TNBC | Basal B | PS-1145 | IKK | NFKB | 7475.065 | uM | inf | inf | 1.0453 | 1.0453 | 0.0000 | -0.0447 | -24.5864 | 2.6262 | |
| SUM185PE | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7532.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0445 | -2.0993 | 0.7413 | |
| MDA-MB-231 | TNBC | Basal B | PS-1145 | IKK | NFKB | 7504.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0441 | -20.3886 | 1.6220 | |
| HCC1569 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 9347.026 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0441 | -22.3629 | 1.2965 | |
| UACC-812 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 10267.026 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0438 | -8.1346 | 0.3125 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 7473.066 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0434 | -6.5378 | 2.3582 | |
| MDA-MB-361 | HER2amp | Luminal | Sulindac sulfide | COX1/2 | COX | 10643.136 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0432 | -6.6439 | 0.5141 | |
| SUM1315MO2 | TNBC | Basal B | Nilotinib | ABL | nRTK | 10875.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0427 | -3.3446 | 0.7643 | |
| CAMA-1 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 9210.026 | uM | inf | inf | 0.9536 | 0.9536 | 0.0000 | -0.0426 | -1.3374 | 0.9102 | |
| ZR-75-1 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7932.052 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0419 | -4.4238 | 0.8877 | |
| MDA-MB-415 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7510.094 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0419 | -8.1247 | 0.8152 | |
| BT-549 | TNBC | Basal B | AG1024 | IGF1R | RTK | 5910.066 | uM | inf | inf | 1.0203 | 1.0203 | 0.0000 | -0.0416 | -10.1657 | 3.0773 | |
| Hs 578T | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7475.084 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0415 | -7.3003 | 2.7804 | |
| CAMA-1 | HR+ | Luminal | Ribavirin | 15348.211 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0410 | -5.7835 | 0.7490 | |||
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7473.091 | uM | inf | inf | 0.9017 | 0.9017 | 0.0000 | -0.0408 | -0.0238 | 2.3297 | |
| Hs 578T | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7475.067 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0408 | -9.2547 | 2.4078 | |
| HCC1428 | HR+ | Luminal | PS-1145 | IKK | NFKB | 7442.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0407 | -6.6988 | 0.7805 | |
| MX1 | Unknown | Unknown | PS-1145 | IKK | NFKB | 7523.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0407 | -9.0127 | 0.7668 | |
| MCF 10F | NM | - | Cetuximab | EGFR | ErbB | 7871.018 | uM | inf | inf | 0.9011 | 0.9011 | 0.0000 | -0.0407 | -0.0154 | 1.1973 | |
| LY2 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 10380.092 | uM | inf | inf | 0.9525 | 0.9525 | 0.0000 | -0.0404 | -1.1056 | 1.4888 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9146.122 | uM | inf | inf | 0.9694 | 0.9694 | 0.0000 | -0.0404 | -1.9847 | 1.3408 | |
| HCC1569 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 12523.152 | uM | inf | inf | 1.0310 | 1.0310 | 0.0000 | -0.0401 | -9.8795 | 0.8423 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 9028.05 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0399 | -2.6337 | 0.9299 |