Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | FTase Inhibitor I | Ftase | MAPK | 12365.167 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0137 | -0.2379 | 2.0273 | |
| HCC1954 | HER2amp | Basal A | SB-3CT | MMP2/9 | MMP | 11055.144 | uM | inf | inf | 0.7776 | 0.7776 | 0.0000 | 0.0714 | 0.3204 | 1.6716 | |
| CAMA-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 9210.024 | uM | inf | 1.21970 | 0.6092 | 0.5429 | 0.5888 | 0.0970 | 0.9466 | 0.8697 | |
| MCF 10F | NM | - | PD184352 | MEK | MAPK | 12254.155 | uM | inf | inf | 0.9696 | 0.9696 | 0.0000 | 0.0271 | -0.1748 | 1.8150 | |
| MCF 10A | NM | Basal B | ICRF-193 | TOP2 | TOP | 11056.151 | uM | inf | 0.04801 | 0.5349 | 0.5474 | 2.0247 | 0.2393 | 0.9850 | 3.0292 | |
| SUM159PT | TNBC | Basal B | Sulindac sulfide | COX1/2 | COX | 10520.136 | uM | inf | inf | 0.9767 | 0.9767 | 0.0000 | -0.0015 | 0.0597 | 4.0331 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 12178.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0369 | 0.0948 | 0.6127 | |
| SUM159PT | TNBC | Basal B | TAPI-0 | TACE/Collagenase | 7531.096 | uM | inf | inf | 0.8694 | 0.8694 | 0.0000 | 0.0391 | 0.3982 | 3.5504 | ||
| 184B5 | NM | Basal | Taxol | TUBB | TUBB | 12979.002 | uM | inf | 0.00871 | 0.5987 | 0.6417 | 4.9974 | 0.2293 | 0.6910 | 1.3178 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 12291.17 | uM | inf | inf | 0.6458 | 0.6458 | 0.0000 | 0.2392 | 0.3142 | 0.5585 | |
| LY2 | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 10816.144 | uM | inf | inf | 0.9453 | 0.9453 | 0.0000 | -0.0111 | -0.0185 | 0.9146 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 12056.145 | uM | inf | inf | 0.9538 | 0.9538 | 0.0000 | 0.0958 | 0.3538 | 0.8365 | |
| HCC38 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7468.067 | uM | inf | 14.3580 | 0.7721 | 0.8436 | 4.9310 | 0.0226 | 0.7090 | 1.3847 | |
| AU565 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 13030.176 | uM | inf | inf | 0.8188 | 0.8188 | 0.0000 | 0.0150 | 0.5497 | 0.9892 | |
| HCC2185 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 12192.161 | uM | inf | inf | 0.8011 | 0.8011 | 0.0000 | 0.0270 | 0.5359 | 0.5555 | |
| SUM159PT | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 11057.135 | uM | inf | 30.93790 | 0.6673 | 0.6670 | 4.9977 | 0.0270 | 0.9663 | 3.9340 | |
| HCC38 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7469.069 | uM | inf | 0.00397 | 0.3547 | 0.5089 | 0.6135 | 0.3258 | 0.8425 | 1.8642 | |
| HCC2185 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7463.065 | uM | inf | 35.55020 | 0.7381 | 0.7589 | 4.9874 | 0.0873 | 0.7220 | 0.5226 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 7874.05 | uM | inf | inf | 0.9256 | 0.9256 | 0.0000 | 0.0249 | 0.5118 | 1.5863 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7492.095 | uM | inf | inf | 0.7935 | 0.7935 | 0.0000 | 0.2394 | -0.1467 | 1.0194 | |
| HCC1187 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7433.098 | uM | inf | inf | 0.9581 | 0.9581 | 0.0000 | 0.0404 | 0.1069 | 1.1392 | |
| HCC1187 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7431.098 | uM | inf | 0.87832 | 0.8139 | 0.8296 | 4.9840 | 0.0429 | 0.8393 | 1.5161 | |
| HCC3153 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 13733.176 | uM | inf | inf | 0.8129 | 0.8129 | 0.0000 | 0.0958 | 0.1866 | 0.7155 | |
| MDA-MB-231 | TNBC | Basal B | Trametinib | MEK | MAPK | 7892.012 | uM | inf | 0.05174 | 0.5884 | 0.6799 | 2.1441 | 0.1234 | 0.9280 | 2.3881 | |
| HCC38 | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 10578.137 | uM | inf | inf | 0.8466 | 0.8466 | 0.0000 | 0.0871 | -0.0040 | 1.8268 |