Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7494.098 | uM | inf | inf | 0.9802 | 0.9802 | 0.0000 | 0.0609 | -0.0984 | 0.9748 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9157.012 | uM | inf | inf | 0.7933 | 0.7933 | 0.0000 | 0.0840 | 0.4934 | 0.8641 | |
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 10816.153 | uM | inf | inf | 0.2645 | 0.2645 | 0.0000 | 0.1603 | 0.3698 | 0.7704 | |
| SUM225CWN | HER2amp | Basal A | GW843682X | PLK | PLK | 10579.139 | uM | inf | inf | 0.8101 | 0.8101 | 0.0000 | 0.0896 | 0.0081 | 1.1260 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7816.017 | uM | inf | inf | 0.9626 | 0.9626 | 0.0000 | 0.1531 | 0.2853 | 1.2318 | |
| MCF 10F | NM | - | FTase Inhibitor I | Ftase | MAPK | 12254.154 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0451 | -13.9008 | 1.6307 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 10579.139 | uM | inf | inf | 0.6972 | 0.6972 | 0.0000 | 0.1100 | -0.0164 | 1.1260 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 12098.157 | uM | inf | inf | 0.7855 | 0.7855 | 0.0000 | 0.0460 | 0.3066 | 1.3067 | |
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9254.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.8730 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7472.098 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0197 | -0.2479 | 1.5098 | |
| LY2 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7865.068 | uM | inf | inf | -0.1814 | -0.1814 | 0.0000 | 0.5691 | 0.4192 | 1.5516 | |
| MCF7 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10997.15 | uM | inf | inf | 0.7198 | 0.7198 | 0.0000 | 0.1640 | 0.5121 | 1.4218 | |
| 21MT-1 | HER2amp | - | Dichloroacetate | PDK | PDK | 13719.176 | uM | inf | inf | 0.9233 | 0.9233 | 0.0000 | 0.0596 | -0.2426 | 0.8672 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 12000.155 | uM | inf | inf | 0.6675 | 0.6675 | 0.0000 | 0.2919 | 0.2735 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 12084.155 | uM | inf | inf | 0.8548 | 0.8548 | 0.0000 | 0.1129 | 0.4499 | 1.2955 | |
| SUM225CWN | HER2amp | Basal A | JNK-IN-5A | JNK | JNK | 12098.144 | uM | inf | inf | 0.8183 | 0.8183 | 0.0000 | 0.1139 | 0.5003 | 1.1959 | |
| HCC1395 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 13538.176 | uM | inf | inf | 0.8042 | 0.8042 | 0.0000 | 0.1436 | 0.3146 | 0.4572 | |
| BT-474 | HER2amp | Luminal | Dactolisib | PI3K | PI3K | 12178.155 | uM | inf | inf | 0.5782 | 0.5782 | 0.0000 | 0.4091 | 0.3793 | 0.8489 | |
| HCC1937 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7453.098 | uM | inf | inf | 0.9252 | 0.9252 | 0.0000 | 0.0007 | 0.1372 | 1.4660 | |
| BT-474 | HER2amp | Luminal | Disulfiram | Proteasome | Proteasome | 13125.174 | uM | inf | inf | 0.6222 | 0.6222 | 0.0000 | 0.1712 | 0.3674 | 0.9685 | |
| 184B5 | NM | Basal | PS-1145 | IKK | NFKB | 5897.065 | uM | inf | inf | 0.9561 | 0.9561 | 0.0000 | 0.0500 | 0.3340 | 1.2996 | |
| MDA-MB-134-VI | HR+ | Luminal | Epirubicin | TOP2 | TOP | 7877.017 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.1618 | 0.3038 | 0.6955 | |
| HCC1395 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 7816.007 | uM | inf | inf | 0.3187 | 0.3187 | 0.0000 | 0.2775 | 0.3760 | 1.1536 | |
| MDA-MB-361 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12379.135 | uM | inf | inf | 1.0351 | 1.0351 | 0.0000 | -0.0361 | -2.8027 | 0.4972 | |
| SUM225CWN | HER2amp | Basal A | Methotrexate | DHFR | Metabolism | 7534.084 | uM | inf | inf | 0.9557 | 0.9557 | 0.0000 | 0.0114 | 0.0130 | 0.8905 |