Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | Sirolimus | MTOR | MTOR | 7789.068 | uM | inf | inf | -0.9304 | -0.9304 | 0.0000 | 1.0723 | 0.4470 | 0.3219 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7793.018 | uM | inf | inf | 0.9318 | 0.9318 | 0.0000 | 0.0067 | 0.3477 | 1.3186 | |
| HCC1187 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 10753.146 | uM | inf | inf | 0.7845 | 0.7845 | 0.0000 | 0.1084 | 0.4052 | 1.4503 | |
| HCC1187 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 13726.176 | uM | inf | inf | 0.6786 | 0.6786 | 0.0000 | 0.3517 | -0.3654 | 0.4071 | |
| HCC1187 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 12696.176 | uM | inf | inf | 0.6436 | 0.6436 | 0.0000 | 0.1782 | 0.0793 | 0.5469 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9035.018 | uM | inf | inf | 0.9083 | 0.9083 | 0.0000 | 0.0297 | 0.4162 | 2.1555 | |
| LY2 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7865.018 | uM | inf | inf | -0.1870 | -0.1870 | 0.0000 | 0.5240 | -0.0010 | 1.1920 | |
| SUM159PT | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7531.095 | uM | inf | inf | 0.9518 | 0.9518 | 0.0000 | 0.0484 | 0.3294 | 3.5302 | |
| SUM159PT | TNBC | Basal B | PS-1145 | IKK | NFKB | 7531.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0370 | -7.5867 | 3.4461 | |
| MB 157 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 9039.068 | uM | inf | inf | 0.0730 | 0.0730 | 0.0000 | 0.5500 | 0.5032 | 0.4510 | |
| HCC1954 | HER2amp | Basal A | TPCA-1 | IKK | NFKB | 7454.093 | uM | inf | inf | 0.7670 | 0.7670 | 0.0000 | 0.2123 | -0.1144 | 1.3347 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7794.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.6812 | |
| SUM159PT | TNBC | Basal B | Ro 32-0432 | PKC | PKC | 10520.142 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0236 | -0.3274 | 3.1766 | |
| 600MPE | HR+ | Luminal | PS-1145 | IKK | NFKB | 5899.065 | uM | inf | inf | 0.8491 | 0.8491 | 0.0000 | 0.1182 | 0.0000 | 1.0946 | |
| HCC38 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7469.098 | uM | inf | inf | 0.9936 | 0.9936 | 0.0000 | 0.0222 | 0.1591 | 2.0111 | |
| LY2 | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 10816.144 | uM | inf | inf | 0.9453 | 0.9453 | 0.0000 | -0.0111 | -0.0185 | 0.9146 | |
| 184A1 | NM | Basal | GSK923295 | CENPE | Kinesin | 9047.001 | uM | inf | inf | 0.0385 | 0.0385 | 0.0000 | 0.2510 | 0.5226 | 0.7701 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7808.052 | uM | inf | inf | 0.9944 | 0.9944 | 0.0000 | -0.0231 | -0.8225 | 2.4842 | |
| MDA-MB-134-VI | HR+ | Luminal | PD184352 | MEK | MAPK | 10998.155 | uM | inf | inf | 0.6159 | 0.6159 | 0.0000 | 0.1450 | 0.0719 | 0.9302 | |
| LY2 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14134.189 | uM | inf | inf | -0.3706 | -0.3706 | 0.0000 | 0.2938 | 0.5072 | 2.7572 | |
| SUM159PT | TNBC | Basal B | Sulindac sulfide | COX1/2 | COX | 10520.136 | uM | inf | inf | 0.9767 | 0.9767 | 0.0000 | -0.0015 | 0.0597 | 4.0331 | |
| MDA-MB-415 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 10938.144 | uM | inf | inf | 0.4357 | 0.4357 | 0.0000 | 0.4162 | 0.0687 | 1.1369 | |
| SUM159PT | TNBC | Basal B | TAPI-0 | TACE/Collagenase | 7531.096 | uM | inf | inf | 0.8694 | 0.8694 | 0.0000 | 0.0391 | 0.3982 | 3.5504 | ||
| HCC38 | TNBC | Basal B | Ribavirin | 15351.211 | uM | inf | inf | 0.7443 | 0.7443 | 0.0000 | 0.0613 | -0.0247 | 1.0866 | |||
| HCC70 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7470.095 | uM | inf | inf | 0.6946 | 0.6946 | 0.0000 | 0.1485 | 0.1176 | 1.1893 |