Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47DKBLUC | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 7545.065 | uM | 4.16720 | 7.36170 | -0.9678 | -0.9790 | 1.9058 | 0.9921 | 0.9981 | 0.9803 | |
| T47DKBLUC | Unknown | Unknown | TCS PIM-1 1 | Pim kinase | PIM | 12608.135 | uM | inf | inf | 0.9426 | 0.9426 | 0.0000 | 0.0396 | 0.0000 | 1.2417 | |
| T47DKBLUC | Unknown | Unknown | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7546.084 | uM | inf | inf | 0.2100 | 0.2100 | 0.0000 | 0.2177 | 0.5102 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Sirolimus | MTOR | MTOR | 7546.069 | uM | 1.33890 | 0.19564 | 0.2689 | 0.2537 | 0.3682 | 0.2972 | 0.8730 | 0.8806 | |
| T47DKBLUC | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 12608.152 | uM | 2.80790 | 2.77780 | 0.0155 | 0.0262 | 5.0000 | 0.1944 | 0.9931 | 1.1477 | |
| T47DKBLUC | Unknown | Unknown | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7546.067 | uM | 8.00270 | 9.96350 | -0.9936 | -0.9953 | 4.9989 | 0.3924 | 0.9975 | 0.8509 | |
| T47DKBLUC | Unknown | Unknown | Taxol | TUBB | TUBB | 13070.002 | uM | 0.01256 | 0.01526 | -0.2471 | -0.2278 | 1.9272 | 0.7275 | 0.9957 | 0.7888 | |
| T47DKBLUC | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 7546.065 | uM | 2.24310 | 5.70120 | -0.9836 | -1.0000 | 1.1777 | 1.0735 | 0.9952 | 0.8300 | |
| T47DKBLUC | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12608.169 | uM | 32.47840 | 78.52930 | -0.1504 | -1.0000 | 1.2443 | 0.1090 | 0.9911 | 1.2559 | |
| T47DKBLUC | Unknown | Unknown | Temsirolimus | MTOR | MTOR | 12608.168 | uM | 27.11690 | 51.12810 | -0.7218 | -1.0000 | 1.7323 | 0.2848 | 0.9094 | 1.0486 | |
| T47DKBLUC | Unknown | Unknown | Torkinib | 15360.211 | uM | 0.00023 | 0.00037 | -0.1763 | -0.1097 | 0.4213 | 0.9138 | 0.9795 | 0.8772 | |||
| T47DKBLUC | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 7544.065 | uM | 5.49570 | 9.17440 | -0.9347 | -0.9451 | 2.0710 | 0.9913 | 0.9941 | 1.2323 | |
| T47DKBLUC | Unknown | Unknown | TPCA-1 | IKK | NFKB | 7544.093 | uM | inf | inf | 0.9073 | 0.9073 | 0.0000 | 0.0221 | 0.2623 | 1.2382 | |
| T47DKBLUC | Unknown | Unknown | TPCA-1 | IKK | NFKB | 7545.1 | uM | 200.6650 | 192.49970 | 0.7246 | 0.0480 | 2.4317 | 0.0514 | 0.6477 | 1.1396 | |
| T47DKBLUC | Unknown | Unknown | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14628.189 | uM | 0.56230 | 0.74057 | -0.9819 | -0.9850 | 3.9529 | 0.7741 | 0.9731 | 0.7555 | |
| T47DKBLUC | Unknown | Unknown | Vorinostat | HDAC | HDAC | 7544.065 | uM | 102.30620 | 173.99410 | -0.9372 | -0.9496 | 2.0044 | 0.7528 | 0.9920 | 1.2323 | |
| T47DKBLUC | Unknown | Unknown | Triciribine | AKT | AKT | 7546.074 | uM | 0.11052 | 0.26310 | -0.1234 | -0.2253 | 0.4289 | 0.4654 | 0.9655 | 0.8465 | |
| T47DKBLUC | Unknown | Unknown | Valproic acid | HDAC | HDAC | 12608.143 | uM | 588.1360 | 1000.00000 | -0.9427 | -0.5082 | 1.3212 | 0.2552 | 0.8479 | 1.1322 | |
| T47DKBLUC | Unknown | Unknown | XRP44X | ELK3 | MAPK | 12608.171 | uM | 1.87240 | 1.88460 | 0.0214 | -0.0164 | 5.0000 | 0.3781 | 0.9604 | 1.0643 | |
| T47DKBLUC | Unknown | Unknown | Vorinostat | HDAC | HDAC | 7546.065 | uM | 54.73330 | 129.0020 | -0.9850 | -1.0000 | 1.2814 | 0.7914 | 0.9970 | 0.8300 | |
| T47DKBLUC | Unknown | Unknown | Vorinostat | HDAC | HDAC | 7545.065 | uM | 113.83720 | 154.75960 | -0.9722 | -0.9704 | 3.5124 | 0.7188 | 0.9990 | 0.9803 | |
| T47DKBLUC | Unknown | Unknown | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14182.189 | uM | 0.85314 | 1.06280 | -1.0000 | -1.0000 | 5.0000 | 0.6973 | 0.9893 | 0.3468 | |
| T47DKBLUC | Unknown | Unknown | ZM-447439 | AURK | AURK | 12608.169 | uM | inf | inf | 0.9693 | 0.9693 | 0.0000 | 0.0194 | 0.0000 | 1.2559 |