Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47DKBLUC | Unknown | Unknown | Nilotinib | ABL | nRTK | 12608.17 | uM | inf | inf | 0.9687 | 0.9687 | 0.0000 | 0.0606 | 0.0000 | 1.0776 | |
| T47DKBLUC | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 12608.135 | uM | 0.15085 | 0.13952 | 0.2081 | 0.1616 | 5.0000 | 0.4217 | 0.9692 | 1.2417 | |
| T47DKBLUC | Unknown | Unknown | Nelfinavir | 13070.174 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0140 | 0.0000 | 0.7993 | |||
| T47DKBLUC | Unknown | Unknown | Omipalisib | PI3K | PI3K | 7545.087 | uM | 0.01629 | 0.03193 | -0.5472 | -0.4318 | 0.9249 | 0.7648 | 0.9922 | 1.1323 | |
| T47DKBLUC | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 7545.066 | uM | 26.99770 | 65.54360 | -0.0153 | -1.0000 | 1.2386 | 0.1570 | 0.9171 | 1.2546 | |
| T47DKBLUC | Unknown | Unknown | NU6102 | CDK1/2 | CDK | 12608.147 | uM | 39.84450 | 90.57230 | 0.2005 | -1.0000 | 1.3378 | 0.1063 | 0.9593 | 1.3009 | |
| T47DKBLUC | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 7544.066 | uM | 54.87290 | 107.74220 | 0.3707 | -1.0000 | 1.6282 | 0.0929 | 0.8708 | 1.0898 | |
| T47DKBLUC | Unknown | Unknown | Omipalisib | PI3K | PI3K | 7544.087 | uM | 0.02145 | 0.03016 | -0.2919 | -0.1951 | 0.9662 | 0.6448 | 0.9818 | 1.1715 | |
| T47DKBLUC | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 7546.066 | uM | 35.39930 | 100.5350 | 0.2077 | -1.0000 | 1.0525 | 0.0787 | 0.9476 | 0.8758 | |
| T47DKBLUC | Unknown | Unknown | Olomoucine II | CDK1 | CDK | 12608.147 | uM | 8.56650 | 7.48840 | 0.2356 | 0.2405 | 4.8755 | 0.2156 | 0.9274 | 1.3009 | |
| T47DKBLUC | Unknown | Unknown | Selumetinib | MEK | MAPK | 12608.155 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0047 | -0.0152 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7545.095 | uM | inf | 0.05456 | 0.7150 | 0.6999 | 0.4189 | 0.2366 | 0.7634 | 1.0123 | |
| T47DKBLUC | Unknown | Unknown | PD173074 | FGFR1/3 | RTK | 7544.093 | uM | 8.09160 | 11.64830 | -0.9258 | -1.0000 | 3.0154 | 0.2267 | 0.9758 | 1.2382 | |
| T47DKBLUC | Unknown | Unknown | PD 98059 | MEK | MAPK | 12608.152 | uM | inf | inf | 0.9193 | 0.9193 | 0.0000 | 0.0522 | 0.0000 | 1.1477 | |
| T47DKBLUC | Unknown | Unknown | PD173074 | FGFR1/3 | RTK | 7545.1 | uM | 17.05940 | 30.44070 | -0.6468 | -1.0000 | 1.8972 | 0.2343 | 0.9490 | 1.1396 | |
| T47DKBLUC | Unknown | Unknown | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7544.095 | uM | inf | 0.07571 | 0.7085 | 0.6381 | 0.1573 | 0.2323 | 0.6143 | 1.0175 | |
| T47DKBLUC | Unknown | Unknown | PD184352 | MEK | MAPK | 12608.155 | uM | inf | inf | 0.9291 | 0.9291 | 0.0000 | 0.0321 | 0.0410 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | PD184352 | MEK | MAPK | 12608.155 | uM | inf | inf | 0.9291 | 0.9291 | 0.0000 | 0.0321 | 0.0410 | 1.1556 | |
| T47DKBLUC | Unknown | Unknown | SB-3CT | MMP2/9 | MMP | 12608.168 | uM | inf | inf | 0.9669 | 0.9669 | 0.0000 | 0.0264 | -0.0226 | 1.0486 | |
| T47DKBLUC | Unknown | Unknown | PS-1145 | IKK | NFKB | 7546.065 | uM | inf | inf | 0.9695 | 0.9695 | 0.0000 | 0.0204 | 0.0000 | 0.8300 | |
| T47DKBLUC | Unknown | Unknown | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7546.095 | uM | 0.24555 | 0.14696 | 0.2826 | 0.3262 | 2.0588 | 0.5126 | 0.9837 | 0.8399 | |
| T47DKBLUC | Unknown | Unknown | PS-1145 | IKK | NFKB | 7545.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -45672.5960 | 0.9803 | |
| T47DKBLUC | Unknown | Unknown | Ribavirin | 15360.211 | uM | 64.03520 | 55.15130 | 0.7199 | 0.2630 | 4.9988 | -0.0057 | 0.8112 | 0.8772 | |||
| T47DKBLUC | Unknown | Unknown | PS-1145 | IKK | NFKB | 7544.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0438 | 0.0000 | 1.2323 | |
| T47DKBLUC | Unknown | Unknown | Purvalanol A | CDK1 | CDK | 7546.067 | uM | inf | 30.67960 | 0.7500 | 0.7500 | 4.9997 | 0.0111 | 0.8401 | 0.8509 |