Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
14649.189
uM
0.36725
0.45735
 -0.9992 -0.9978 5.0000 0.7780
0.9985
 0.5692
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
14649.189
uM
0.36725
0.45735
 -0.9992 -0.9978 5.0000 0.7780
0.9985
 0.5692
MX1
Unknown
Unknown
 Nilotinib
ABL
nRTK
10874.145
uM
inf
inf
 1.0500 1.0500 0.0000 -0.0057
-0.0198
 0.8505
MX1
Unknown
Unknown
 Pevonedistat
NAE1
NAE1
10874.148
uM
inf
inf
 0.9329 0.9329 0.0000 0.0954
0.0789
 0.6972
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
10874.145
uM
0.12033
0.15614
 -0.9820 -0.9785 4.1620 0.8984
0.9993
 0.8505
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
10874.145
uM
0.12033
0.15614
 -0.9820 -0.9785 4.1620 0.8984
0.9993
 0.8505
MX1
Unknown
Unknown
 Nelfinavir
12667.174
uM
6.93420
10.10980
 -0.9543 -1.0000 2.9138 0.1831
0.990
 0.8129
MX1
Unknown
Unknown
 Valproic acid
HDAC
HDAC
10644.143
uM
355.22210
734.46760
 -0.9986 -1.0000 1.5124 0.6015
0.9444
 0.6221
MX1
Unknown
Unknown
 Sigma A6730
AKT
AKT
10874.153
uM
4.18450
7.94640
 -0.9715 -1.0000 1.7130 0.4452
0.9518
 0.8467
MX1
Unknown
Unknown
 PD184352
MEK
MAPK
12220.155
uM
inf
inf
 0.1151 0.1151 0.0000 0.3578
0.5513
 0.4858
MX1
Unknown
Unknown
 Olomoucine II
CDK1
CDK
10644.147
uM
6.00730
7.48350
 -1.0000 -1.0000 5.0000 0.4357
0.9851
 0.4349
HBL-100
Unknown
Unknown
 Docetaxel
TUBB
TUBB
7808.002
uM
0.00194
0.00155
 0.3152 0.1983 2.2864 0.5513
0.9438
 2.3302
MX1
Unknown
Unknown
 PD 98059
MEK
MAPK
12220.159
uM
45.76140
265.90990
 0.2868 -1.0000 0.6243 0.1443
0.7928
 0.4788
MX1
Unknown
Unknown
 Oxamflatin
HDAC
HDAC
10644.147
uM
0.48053
0.66182
 -0.9999 -0.9992 3.4303 0.7292
0.9935
 0.4349
MX1
Unknown
Unknown
 Olomoucine II
CDK1
CDK
10874.147
uM
5.57140
7.10210
 -0.9959 -0.9966 4.5164 0.4144
0.9985
 0.7482
MX1
Unknown
Unknown
 Omipalisib
PI3K
PI3K
10644.087
uM
0.00548
0.01873
 -0.9983 -0.9866 0.8862 1.1685
0.9633
 0.5708
MX1
Unknown
Unknown
 PD 98059
MEK
MAPK
10644.136
uM
80.20970
150.0160
 0.3780 -0.7441 1.4559 0.0899
0.6828
 0.5562
MX1
Unknown
Unknown
 Selumetinib
MEK
MAPK
10644.146
uM
0.60435
1.87970
 -0.9223 -1.0000 0.9682 0.5608
0.9829
 0.5967
MX1
Unknown
Unknown
 PS-1145
IKK
NFKB
7523.065
uM
inf
inf
 1.0500 1.0500 0.0000 -0.0407
-9.0127
 0.7668
MX1
Unknown
Unknown
 PD184352
MEK
MAPK
10874.155
uM
13.13740
85.26950
 0.2694 -1.0000 0.5874 0.1658
0.8268
 0.8099
MX1
Unknown
Unknown
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7523.095
uM
inf
0.22243
 0.4987 0.5629 2.6377 0.3218
0.9364
 0.8203
MX1
Unknown
Unknown
 Selumetinib
MEK
MAPK
10874.155
uM
0.39717
0.94112
 -0.4198 -0.4296 0.7188 0.4271
0.9765
 0.8099
MX1
Unknown
Unknown
 SB-3CT
MMP2/9
MMP
12220.144
uM
0.21073
1.6780
 -0.9996 -1.0000 0.5295 0.7991
0.7647
 0.5126
MX1
Unknown
Unknown
 Selumetinib
MEK
MAPK
12220.155
uM
0.02993
0.55898
 -0.6163 -1.0000 0.3753 0.7675
0.9750
 0.4858
MX1
Unknown
Unknown
 Valproic acid
HDAC
HDAC
12220.143
uM
16.61280
137.74590
 -0.9997 -1.0000 0.5194 0.8265
0.8979
 0.4532