Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MX1
Unknown
Unknown
 Sigma A6730
AKT
AKT
10644.141
uM
3.1030
4.14240
 -1.0000 -0.9981 3.7981 0.3955
0.9970
 0.4530
MX1
Unknown
Unknown
 Sigma A6730
AKT
AKT
12220.158
uM
1.68540
3.56750
 -0.9998 -1.0000 1.4651 0.4749
0.9683
 0.4308
MX1
Unknown
Unknown
 L-779450
BRAF
MAPK
10644.137
uM
6.30710
8.48390
 -0.9907 -1.0000 3.7054 0.2296
0.9774
 0.5827
MX1
Unknown
Unknown
 L-779450
BRAF
MAPK
10874.149
uM
19.42320
24.16740
 -0.6573 -0.9909 4.9993 0.1170
0.9794
 0.8239
MX1
Unknown
Unknown
 SB-3CT
MMP2/9
MMP
10874.144
uM
16.8960
25.00610
 -0.9824 -1.0000 2.8023 0.2025
0.9954
 0.7282
MX1
Unknown
Unknown
 SB-3CT
MMP2/9
MMP
10644.144
uM
13.42830
26.81710
 -0.8221 -1.0000 1.5883 0.2830
0.9641
 0.5357
MX1
Unknown
Unknown
 Ro 32-0432
PKC
PKC
10644.142
uM
inf
inf
 0.8577 0.8577 0.0000 0.0773
-0.0086
 0.5163
MX1
Unknown
Unknown
 Purvalanol A
CDK1
CDK
7523.067
uM
inf
inf
 0.8338 0.8338 0.0000 0.0997
0.0000
 0.8380
MX1
Unknown
Unknown
 PD184352
MEK
MAPK
10644.146
uM
6.09890
9.03380
 -0.6534 -0.6758 2.1767 0.3395
0.9581
 0.5967
MX1
Unknown
Unknown
 PD184352
MEK
MAPK
10644.146
uM
6.09890
9.03380
 -0.6534 -0.6758 2.1767 0.3395
0.9581
 0.5967
MX1
Unknown
Unknown
 PD184352
MEK
MAPK
10874.155
uM
13.13740
85.26950
 0.2694 -1.0000 0.5874 0.1658
0.8268
 0.8099
MX1
Unknown
Unknown
 PD184352
MEK
MAPK
12220.155
uM
inf
inf
 0.1151 0.1151 0.0000 0.3578
0.5513
 0.4858
MX1
Unknown
Unknown
 PD 98059
MEK
MAPK
10874.152
uM
inf
inf
 0.6467 0.6467 0.0000 0.1312
0.3463
 0.7706
MX1
Unknown
Unknown
 Oxamflatin
HDAC
HDAC
10874.147
uM
0.49094
1.04360
 -0.9895 -1.0000 1.4568 0.6277
0.9981
 0.7482
MX1
Unknown
Unknown
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
10874.154
uM
0.06032
0.34228
 -0.9969 -1.0000 0.6329 0.7495
0.9768
 0.7639
MX1
Unknown
Unknown
 LBH589
HDAC
HDAC
10874.154
uM
0.06423
0.11763
 -0.9921 -0.9928 1.8075 0.8595
0.9989
 0.7639
MX1
Unknown
Unknown
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
10644.142
uM
0.05884
0.18232
 -0.9999 -1.0000 0.9714 1.0132
0.9422
 0.5163
MX1
Unknown
Unknown
 Nilotinib
ABL
nRTK
10644.145
uM
3.15010
3.71960
 -0.5688 -0.4876 4.0955 0.4971
0.9711
 0.4300
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
10644.145
uM
0.04734
0.07256
 -1.0000 -1.0000 2.5730 1.0527
0.9991
 0.4300
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
14278.189
uM
inf
inf
 -0.9921 -0.9921 0.0000 0.7370
0.5547
 0.7296
MX1
Unknown
Unknown
 Pevonedistat
NAE1
NAE1
10644.135
uM
1.72590
2.57450
 -0.9306 -0.8286 2.4439 0.5153
0.9521
 0.5273
MX1
Unknown
Unknown
 Pevonedistat
NAE1
NAE1
12220.135
uM
1.17960
1.72690
 -0.9001 -0.8935 2.6890 0.6834
0.9144
 0.6564
MX1
Unknown
Unknown
 Methylglyoxal
13567.184
uM
468.21670
705.16970
 -0.9987 -1.0000 2.6828 0.7669
0.9728
 0.6921
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
14278.189
uM
inf
inf
 -0.9921 -0.9921 0.0000 0.7370
0.5547
 0.7296
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
10644.145
uM
0.04734
0.07256
 -1.0000 -1.0000 2.5730 1.0527
0.9991
 0.4300