Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 9254.121 | uM | 1.88410 | 7.72860 | -0.6959 | -0.9260 | 0.7425 | 0.3745 | 0.9815 | 1.2352 | |
| HCC1395 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 9258.121 | uM | 0.8180 | 1.81820 | -0.9944 | -0.9150 | 1.3024 | 0.6132 | 0.9822 | 0.4800 | |
| HCC38 | TNBC | Basal B | PD184352 | MEK | MAPK | 11850.155 | uM | inf | inf | 0.9060 | 0.9060 | 0.0000 | 0.0877 | 0.0000 | 2.1810 | |
| HCC38 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 10578.1 | uM | 8.71610 | 17.04880 | -0.9474 | -1.0000 | 1.6375 | 0.3665 | 0.8880 | 1.6202 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 12000.155 | uM | inf | inf | 0.6675 | 0.6675 | 0.0000 | 0.2919 | 0.2735 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 12084.155 | uM | inf | inf | 0.8548 | 0.8548 | 0.0000 | 0.1129 | 0.4499 | 1.2955 | |
| HCC38 | TNBC | Basal B | PD 98059 | MEK | MAPK | 10578.136 | uM | inf | 25.79330 | 0.5933 | 0.5928 | 4.8756 | 0.0532 | 0.8707 | 1.5577 | |
| HCC1395 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 13538.176 | uM | inf | inf | 0.8042 | 0.8042 | 0.0000 | 0.1436 | 0.3146 | 0.4572 | |
| HCC1395 | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 13538.174 | uM | inf | 0.14414 | 0.6866 | 0.6441 | 5.0000 | 0.1678 | 0.7406 | 0.4615 | |
| HCC38 | TNBC | Basal B | PS-1145 | IKK | NFKB | 7469.065 | uM | inf | 61.95750 | 0.9161 | 0.9150 | 0.8933 | 0.0080 | 0.6490 | 2.0006 | |
| HCC38 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 10418.093 | uM | 3.53430 | 7.85550 | -0.9028 | -1.0000 | 1.3755 | 0.2763 | 0.9686 | 0.9872 | |
| HCC1395 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 7813.002 | uM | 0.00427 | 0.00565 | -0.3992 | -0.3837 | 2.0301 | 0.8129 | 0.9487 | 0.8463 | |
| HCC1395 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9254.002 | uM | 0.00740 | 0.00860 | -0.5219 | -0.5591 | 5.0000 | 0.8610 | 0.9829 | 0.3983 | |
| HCC38 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 7468.093 | uM | 3.78550 | 10.17590 | -0.7786 | -1.0000 | 1.1110 | 0.2905 | 0.8947 | 1.4007 | |
| HCC1395 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9258.002 | uM | 0.00521 | 0.00815 | -0.6370 | -0.6272 | 1.8161 | 0.9088 | 0.9971 | 0.7065 | |
| HCC1395 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 7816.007 | uM | inf | inf | 0.3187 | 0.3187 | 0.0000 | 0.2775 | 0.3760 | 1.1536 | |
| HCC38 | TNBC | Basal B | PS-1145 | IKK | NFKB | 7468.065 | uM | inf | inf | 0.8447 | 0.8447 | 0.0000 | 0.0735 | 0.5698 | 1.5219 | |
| HCC38 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7469.095 | uM | inf | inf | 0.9298 | 0.9298 | 0.0000 | -0.0029 | 0.3387 | 1.8946 | |
| HCC1395 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 9258.121 | uM | 0.06051 | 0.20762 | -0.9952 | -0.9809 | 0.8807 | 0.9474 | 0.9235 | 0.4800 | |
| HCC1395 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 7813.007 | uM | 0.48027 | 1.07560 | -0.9401 | -0.8913 | 1.2692 | 0.6307 | 0.9841 | 0.8361 | |
| HCC38 | TNBC | Basal B | PD184352 | MEK | MAPK | 11850.155 | uM | inf | inf | 0.9060 | 0.9060 | 0.0000 | 0.0877 | 0.0000 | 2.1810 | |
| HCC1395 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 9254.121 | uM | 0.26202 | 0.84031 | -0.7184 | -0.7501 | 0.7863 | 0.6266 | 0.9951 | 1.2352 | |
| HCC1395 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7816.017 | uM | inf | inf | 0.6386 | 0.6386 | 0.0000 | 0.2394 | 0.3980 | 1.2318 | |
| HCC38 | TNBC | Basal B | PS-1145 | IKK | NFKB | 10418.065 | uM | inf | inf | 0.7550 | 0.7550 | 0.0000 | 0.0403 | 0.2487 | 0.9401 | |
| HCC38 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 10418.095 | uM | inf | inf | 0.7496 | 0.7496 | 0.0000 | 0.1450 | 0.4999 | 1.1425 |