Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 11939.161 | uM | 113.17760 | 580.37840 | 0.5263 | -1.0000 | 0.6721 | 0.1062 | 0.6994 | 1.6513 | |
| ZR75B | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14149.189 | uM | 2.24770 | 2.11580 | -0.1058 | 0.0924 | 3.3807 | 0.2949 | 0.9239 | 2.1888 | |
| ZR75B | HR+ | Luminal | GSK1070916 | AURK | AURK | 9972.001 | uM | 0.74505 | 17.52730 | -0.2305 | -1.0000 | 0.3479 | 0.3511 | 0.9099 | 1.0521 | |
| ZR75B | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7555.067 | uM | inf | inf | 0.9271 | 0.9271 | 0.0000 | 0.0501 | 0.4768 | 1.6890 | |
| ZR75B | HR+ | Luminal | ZM-447439 | AURK | AURK | 11939.16 | uM | inf | 0.38150 | 0.3784 | 0.5796 | 4.9967 | 0.1978 | 0.7753 | 1.6749 | |
| ZR75B | HR+ | Luminal | Mebendazole | 13595.174 | uM | 0.20772 | 0.1040 | 0.2460 | 0.3358 | 1.6096 | 0.3435 | 0.9574 | 1.8596 | |||
| ZR75B | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 11939.135 | uM | inf | 0.11569 | 0.4380 | 0.5233 | 4.9998 | 0.2521 | 0.8397 | 1.5987 | |
| ZR75B | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7555.091 | uM | 7.21980 | 8.73030 | -0.7894 | -0.7926 | 4.9997 | 0.3470 | 0.9942 | 1.6040 | |
| ZR75B | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9997.001 | uM | 0.13661 | 2.1940 | -0.6969 | -1.0000 | 0.3957 | 0.4891 | 0.8692 | 1.0003 | |
| ZR75B | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7555.067 | uM | 0.18893 | 2.06690 | -0.8416 | -1.0000 | 0.4592 | 0.5015 | 0.9134 | 1.6890 | |
| ZR75B | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7555.065 | uM | 100.87210 | 206.42740 | -0.5309 | -0.5439 | 1.0279 | 0.5527 | 0.9943 | 1.7561 | |
| ZR75B | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9997.011 | uM | 0.03217 | 0.01921 | 0.4132 | 0.4620 | 4.9943 | 0.3567 | 0.9393 | 1.0551 | |
| ZR75B | HR+ | Luminal | Everolimus | MTOR | MTOR | 11939.164 | uM | 0.19830 | 5.11160 | -0.7640 | -1.0000 | 0.3381 | 0.5367 | 0.8695 | 1.6455 | |
| ZR75B | HR+ | Luminal | Valproic acid | HDAC | HDAC | 11939.143 | uM | 645.46960 | 1000.00000 | -0.7891 | -0.3543 | 1.2237 | 0.2425 | 0.8011 | 1.7414 | |
| ZR75B | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9972.121 | uM | 0.11460 | 0.30861 | -0.7860 | -0.7261 | 0.9054 | 0.7654 | 0.9839 | 1.1034 | |
| ZR75B | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7555.091 | uM | 222.88850 | 687.59880 | 0.7916 | -0.8665 | 0.8924 | 0.0120 | 0.8409 | 1.6040 | |
| ZR75B | HR+ | Luminal | Omipalisib | PI3K | PI3K | 7555.086 | uM | 0.00574 | 0.00917 | -0.2595 | -0.2589 | 0.8890 | 0.8062 | 0.9953 | 1.6344 | |
| ZR75B | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9997.001 | uM | 0.04836 | 0.03537 | 0.0463 | 0.2487 | 2.1998 | 0.3757 | 0.9454 | 1.0003 | |
| ZR75B | HR+ | Luminal | LBH589 | HDAC | HDAC | 11939.154 | uM | 0.08770 | 0.17847 | -0.7416 | -0.7405 | 1.2787 | 0.7227 | 0.9983 | 1.7246 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9997.049 | uM | 0.10140 | 0.04753 | 0.1808 | 0.3301 | 1.4243 | 0.3756 | 0.8932 | 1.1423 | |
| ZR75B | HR+ | Luminal | Taxol | TUBB | TUBB | 9997.002 | uM | 0.10845 | 0.04289 | 0.1042 | 0.2100 | 0.5873 | 0.3883 | 0.8980 | 0.9751 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9997.121 | uM | 1.66170 | 0.86071 | 0.2842 | 0.3340 | 1.6759 | 0.2165 | 0.9826 | 1.1121 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9972.037 | uM | 0.02505 | 0.0480 | -0.7246 | -0.3436 | 0.8045 | 0.7513 | 0.9126 | 1.0789 | |
| ZR75B | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7555.098 | uM | 11.90210 | 27.38920 | -0.5278 | -1.0000 | 1.3182 | 0.1866 | 0.9959 | 1.6495 | |
| ZR75B | HR+ | Luminal | Sigma A6730 | AKT | AKT | 11939.158 | uM | 1.32790 | 12.06410 | -0.4497 | -1.0000 | 0.4979 | 0.4063 | 0.9723 | 1.7251 |