Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 12003.166 | uM | inf | inf | 0.3485 | 0.3485 | 0.0000 | 0.2159 | 0.5536 | 1.0782 | |
| ZR-75-1 | HR+ | Luminal | PD184352 | MEK | MAPK | 11660.146 | uM | 583.9090 | 1000.00000 | 0.4704 | -0.0361 | 0.1295 | 0.2471 | 0.6207 | 0.9684 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9958.012 | uM | 0.05477 | 0.06902 | -0.3984 | -0.3592 | 2.3412 | 0.7512 | 0.9975 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14296.189 | uM | inf | inf | -0.9346 | -0.9346 | 0.0000 | 0.5051 | 0.4890 | 0.6639 | |
| ZR-75-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 7931.016 | uM | 81.61130 | 655.20850 | 0.6483 | -0.9996 | 0.5273 | 0.0694 | 0.9347 | 1.3152 | |
| ZR-75-1 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9958.021 | uM | 39.10730 | 113.82250 | -0.9903 | -1.0000 | 1.0283 | 0.4031 | 0.9860 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7552.098 | uM | inf | inf | 0.8246 | 0.8246 | 0.0000 | 0.1123 | 0.2173 | 1.1882 | |
| ZR-75-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 11660.149 | uM | inf | inf | 0.3716 | 0.3716 | 0.0000 | 0.1545 | 0.5721 | 1.0690 | |
| ZR-75-1 | HR+ | Luminal | NU6102 | CDK1/2 | CDK | 11660.147 | uM | 20.51450 | 57.39670 | -0.0971 | -1.0000 | 1.0678 | 0.2060 | 0.8857 | 1.0592 | |
| ZR-75-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 11660.145 | uM | 0.47233 | 1.21540 | -0.8693 | -0.8719 | 1.0678 | 0.5829 | 0.9976 | 0.9169 | |
| ZR-75-1 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 11660.147 | uM | 7.57160 | 8.21220 | -0.3544 | -0.2505 | 5.0000 | 0.3486 | 0.9277 | 1.0592 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7932.017 | uM | 10.07150 | 18.02160 | -0.8999 | -0.9278 | 1.8033 | 0.4331 | 0.9931 | 1.0712 | |
| ZR-75-1 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9958.002 | uM | 0.00820 | 0.00391 | 0.2081 | 0.3160 | 1.3506 | 0.4063 | 0.9652 | 0.5113 | |
| ZR-75-1 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7931.042 | uM | 0.05981 | 0.05868 | -0.1991 | 0.0302 | 3.2415 | 0.4874 | 0.9640 | 1.3878 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 7932.001 | uM | inf | inf | -0.2938 | -0.2938 | 0.0000 | 0.1774 | 0.3309 | 1.0256 | |
| ZR-75-1 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 11660.144 | uM | 0.54362 | 0.43447 | 0.2310 | 0.3370 | 4.9998 | 0.2977 | 0.9227 | 1.0279 | |
| ZR-75-1 | HR+ | Luminal | Dichloroacetate | PDK | PDK | 12677.176 | uM | inf | inf | 0.7705 | 0.7705 | 0.0000 | 0.0825 | 0.4272 | 0.9376 | |
| ZR-75-1 | HR+ | Luminal | IKK16 | IKK | NFKB | 7553.093 | uM | 4.13320 | 5.78270 | -0.9589 | -0.9605 | 3.1920 | 0.4169 | 0.9936 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 11660.154 | uM | inf | inf | 0.8493 | 0.8493 | 0.0000 | 0.1199 | -0.0998 | 0.9388 | |
| ZR-75-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 12003.159 | uM | 1.3180 | 2.03380 | -0.9596 | -0.9811 | 2.5036 | 0.8286 | 0.9208 | 1.2466 | |
| ZR-75-1 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14927.203 | uM | 0.01115 | 0.04208 | -0.8960 | -0.8481 | 0.7465 | 1.0346 | 0.9623 | 0.8860 | |
| ZR-75-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 12003.169 | uM | 2.24660 | 17.89330 | -0.2861 | -1.0000 | 0.5295 | 0.3270 | 0.9664 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 11660.144 | uM | 0.00395 | 1.80850 | -0.9804 | -1.0000 | 0.1793 | 0.8085 | 0.6199 | 1.0279 | |
| ZR-75-1 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 11660.151 | uM | 1.15050 | 1.05550 | 0.1402 | 0.1749 | 4.9958 | 0.3806 | 0.8954 | 0.9483 | |
| ZR-75-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 12003.157 | uM | 3.97190 | 2.18140 | 0.4190 | 0.0603 | 0.2146 | 0.3302 | 0.7495 | 1.0729 |