Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9913.002 | uM | 0.00368 | 0.00315 | 0.2367 | 0.1420 | 2.1296 | 0.5464 | 0.9437 | 0.6723 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 10754.149 | uM | 31.66270 | 61.84540 | 0.4861 | -0.3743 | 0.8347 | 0.0862 | 0.8570 | 1.3535 | |
| UACC-812 | HER2amp | Luminal | Olomoucine II | CDK1 | CDK | 10754.147 | uM | 7.50240 | 7.28980 | 0.0013 | 0.0669 | 5.0000 | 0.2143 | 0.9803 | 1.2793 | |
| UACC-812 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 7547.087 | uM | 0.00057 | 0.00410 | -0.5482 | -0.6130 | 0.4045 | 1.0863 | 0.9374 | 0.9847 | |
| UACC-812 | HER2amp | Luminal | Olomoucine II | CDK1 | CDK | 11938.147 | uM | 5.620 | 7.54930 | -0.9969 | -1.0000 | 3.7226 | 0.5772 | 0.9236 | 0.6765 | |
| UACC-812 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 10580.137 | uM | inf | inf | 0.5974 | 0.5974 | 0.0000 | 0.1466 | 0.4745 | 0.8535 | |
| UACC-812 | HER2amp | Luminal | Mebendazole | 13078.174 | uM | 4.07970 | 51.75050 | -0.1950 | -1.0000 | 0.4325 | 0.3427 | 0.5767 | 0.6238 | |||
| UACC-812 | HER2amp | Luminal | Celecoxib | COX2 | COX | 10580.136 | uM | inf | inf | 0.9217 | 0.9217 | 0.0000 | 0.1643 | 0.0000 | 0.7205 | |
| UACC-812 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 10754.15 | uM | 10.6930 | 6.26750 | 0.3450 | 0.1408 | 0.6189 | 0.1518 | 0.8661 | 1.1628 | ||
| UACC-812 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 7926.017 | uM | 0.26465 | 0.28273 | -0.4007 | -0.1958 | 5.0000 | 0.6961 | 0.6364 | 0.8896 | |
| UACC-812 | HER2amp | Luminal | Bosutinib | Src | nRTK | 11938.145 | uM | 1.34870 | 18.15590 | -0.4542 | -1.0000 | 0.4226 | 0.4837 | 0.7749 | 0.7062 | |
| UACC-812 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 10267.011 | uM | 0.04535 | 0.05545 | -0.8887 | -0.8671 | 4.9991 | 1.1102 | 0.9988 | 0.3592 | |
| UACC-812 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 10754.154 | uM | 45.78120 | 73.31260 | 0.7254 | -1.0000 | 2.3332 | 0.0513 | 0.6570 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 10580.142 | uM | inf | inf | 0.7446 | 0.7446 | 0.0000 | 0.0399 | 0.5308 | 0.8039 | |
| UACC-812 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 14227.189 | uM | 0.28507 | 0.31850 | -0.2854 | -0.1142 | 1.8548 | 0.5125 | 0.9520 | 1.2712 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10580.138 | uM | 16.92470 | 30.4930 | -0.8643 | -1.0000 | 1.8661 | 0.3447 | 0.8943 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 10420.095 | uM | 0.00405 | 0.00426 | -0.9993 | -0.0422 | 1.5655 | 0.6669 | 0.5965 | 0.5783 | |
| UACC-812 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10754.154 | uM | 2.32050 | 5.79750 | -0.9836 | -1.0000 | 1.1998 | 0.3163 | 0.9698 | 1.3934 | |
| UACC-812 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10754.146 | uM | inf | inf | 1.0409 | 1.0409 | 0.0000 | -0.0246 | -0.2891 | 1.2483 | |
| UACC-812 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 11938.16 | uM | inf | inf | 0.9148 | 0.9148 | 0.0000 | 0.1264 | 0.0685 | 0.6405 | ||
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 10267.001 | uM | 6.73740 | 8.15430 | -0.7961 | -0.7976 | 4.9966 | 0.2231 | 0.8483 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10580.142 | uM | 2.10970 | 4.16050 | -0.9752 | -1.0000 | 1.6178 | 0.5390 | 0.9889 | 0.8039 | |
| UACC-812 | HER2amp | Luminal | Disulfiram | Proteasome | Proteasome | 13078.174 | uM | 0.08364 | 0.09567 | -0.3146 | -0.4793 | 5.0000 | 0.8051 | 0.9537 | 0.6238 | |
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 10150.001 | uM | 3.88470 | 13.45150 | -0.5015 | -1.0000 | 0.8845 | 0.2772 | 0.8331 | 0.3255 | |
| UACC-812 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 10580.145 | uM | 0.14153 | 0.25065 | -0.7017 | -0.6324 | 1.4303 | 0.7825 | 0.9578 | 0.9000 |