Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-893 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9933.021 | uM | 67.82910 | 84.49720 | -0.9980 | -1.0000 | 4.9999 | 0.2854 | 0.7469 | 0.3311 | |
| UACC-893 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9933.034 | uM | inf | inf | -0.4193 | -0.4193 | 0.0000 | 0.2801 | 0.4156 | 0.5612 | ||
| UACC-893 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 9933.034 | uM | 0.58404 | 0.72713 | -0.9988 | -0.9956 | 5.0000 | 0.7348 | 0.9934 | 0.5612 | |
| UACC-893 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 9933.034 | uM | 46.61750 | 58.07280 | -0.5368 | -1.0000 | 5.0000 | 0.0739 | 0.9856 | 0.5612 | |
| UACC-893 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9953.001 | uM | 0.00892 | 0.00997 | -0.6091 | -0.3691 | 5.0000 | 0.8976 | 0.9020 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9953.001 | uM | 0.01306 | 0.01537 | -0.7981 | -0.6263 | 5.0000 | 0.9629 | 0.9641 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9953.001 | uM | 2.4110 | 9.98620 | -0.5113 | -1.0000 | 0.7730 | 0.3312 | 0.8672 | 0.3377 | |
| UACC-893 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 9953.002 | uM | 0.03948 | 0.02704 | 0.1904 | 0.3108 | 2.5685 | 0.2992 | 0.8678 | 0.4141 | |
| UACC-893 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9953.002 | uM | 0.04411 | 0.02816 | -0.0273 | 0.1998 | 1.1364 | 0.4530 | 0.8027 | 0.4141 | |
| UACC-893 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9953.011 | uM | 519.08980 | 646.64620 | -0.9708 | -1.0000 | 5.0000 | 0.1507 | 0.9684 | 0.4697 | |
| UACC-893 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9953.011 | uM | 163.95320 | 198.53320 | -0.7581 | -0.7646 | 4.8487 | 0.1371 | 0.9838 | 0.4697 | |
| UACC-893 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9953.011 | uM | 141.95250 | 152.09020 | 0.4790 | -0.2034 | 4.9474 | 0.0634 | 0.7013 | 0.4697 | |
| UACC-893 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9953.037 | uM | 0.01002 | 0.01932 | -0.9981 | -0.9490 | 1.6193 | 1.2817 | 0.9974 | 0.4884 | |
| UACC-893 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 9953.049 | uM | 1.32520 | 5.98960 | -0.6307 | -1.0000 | 0.7283 | 0.3486 | 0.9275 | 0.5411 | |
| UACC-893 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9953.049 | uM | 0.01780 | 0.04870 | -0.9172 | -0.8273 | 0.9702 | 1.0608 | 0.9866 | 0.5411 | |
| UACC-893 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9953.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0816 | 0.0269 | 0.5411 | |
| ZR-75-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 9958.001 | uM | 0.60021 | 78.49440 | -0.0998 | -1.0000 | 0.2254 | 0.3728 | 0.7713 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9958.001 | uM | 0.03119 | 0.03366 | -0.4843 | -0.2129 | 4.6381 | 0.6613 | 0.9667 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9958.001 | uM | inf | inf | -0.6349 | -0.6349 | 0.0000 | 0.4214 | 0.4925 | 0.5164 | |
| ZR-75-1 | HR+ | Luminal | Taxol | TUBB | TUBB | 9958.002 | uM | 0.01074 | 0.00977 | 0.1235 | 0.1880 | 4.9851 | 0.5278 | 0.9797 | 0.5113 | |
| ZR-75-1 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9958.002 | uM | 0.00820 | 0.00391 | 0.2081 | 0.3160 | 1.3506 | 0.4063 | 0.9652 | 0.5113 | |
| ZR-75-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 9958.012 | uM | 19.68590 | 17.35330 | 0.6507 | 0.2298 | 4.8786 | 0.0043 | 0.9189 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9958.012 | uM | 0.05477 | 0.06902 | -0.3984 | -0.3592 | 2.3412 | 0.7512 | 0.9975 | 0.5705 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9958.021 | uM | 6.21370 | 19.19280 | -0.9793 | -1.0000 | 0.9741 | 0.4490 | 0.9806 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9958.021 | uM | 2.61520 | 8.32030 | -0.9996 | -1.0000 | 0.9493 | 0.6504 | 0.9645 | 0.5129 |