Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 10262.001 | uM | 0.02489 | 0.02384 | -0.1295 | 0.0319 | 1.5210 | 0.5180 | 0.9664 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK1070916 | AURK | AURK | 10262.001 | uM | 0.45278 | 8.84950 | -0.4796 | -1.0000 | 0.3696 | 0.3939 | 0.8872 | 0.6105 | |
| HCC1937 | TNBC | Basal A | Taxol | TUBB | TUBB | 10262.002 | uM | 0.01348 | 0.01656 | -0.4597 | -0.1999 | 1.6313 | 0.6733 | 0.9646 | 0.6356 | |
| HCC1937 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 10262.002 | uM | 0.00534 | 0.00521 | 0.0885 | 0.0565 | 5.0000 | 0.5451 | 0.9835 | 0.6356 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 10262.012 | uM | inf | inf | 0.2614 | 0.2614 | 0.0000 | 0.2012 | 0.480 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 10262.012 | uM | 0.03179 | 0.04650 | -0.7724 | -0.7679 | 2.4460 | 1.0317 | 0.9981 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 10262.021 | uM | 5.06270 | 8.92370 | -0.9411 | -0.8884 | 1.8018 | 0.4842 | 0.9909 | 0.6806 | |
| HCC1937 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10262.021 | uM | 10.13520 | 27.94670 | -0.9380 | -1.0000 | 1.0831 | 0.4678 | 0.9912 | 0.6806 | |
| HCC1937 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 10262.021 | uM | 37.6510 | 50.43530 | -0.9519 | -0.8597 | 3.4222 | 0.4481 | 0.9944 | 0.6806 | |
| HCC1937 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 10262.034 | uM | 2.42290 | 59.75010 | -0.9033 | -1.0000 | 0.3428 | 0.7559 | 0.9172 | 0.6634 | ||
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 10262.034 | uM | 6.33790 | 16.09640 | -0.8558 | -1.0000 | 1.1787 | 0.2986 | 0.9773 | 0.6634 | |
| HCC1937 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 10262.034 | uM | 0.29470 | 0.74270 | -0.8572 | -0.8195 | 1.0498 | 0.6968 | 0.9915 | 0.6634 | |
| HCC2185 | TNBC | Luminal | GSK1070916 | AURK | AURK | 10263.001 | uM | 0.14569 | 3.45390 | -0.4750 | -1.0000 | 0.3470 | 0.5409 | 0.8338 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 10263.001 | uM | 0.03162 | 0.03969 | -0.5522 | -0.6572 | 3.6909 | 0.9431 | 0.9385 | 0.3258 | |
| HCC2185 | TNBC | Luminal | GSK461364 | PLK1 | PLK | 10263.001 | uM | 0.00423 | 0.00507 | -0.9767 | -0.7367 | 5.0000 | 1.1583 | 0.9733 | 0.3258 | |
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 10263.034 | uM | 0.59694 | 64.10150 | -0.9993 | -1.0000 | 0.2349 | 0.7794 | 0.7511 | 0.3750 | ||
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 10263.034 | uM | 1.76130 | 2.7730 | -0.5448 | -0.5665 | 1.6689 | 0.4269 | 0.9813 | 0.3750 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 10263.034 | uM | 0.02525 | 0.11148 | -1.0000 | -1.0000 | 0.7398 | 1.0785 | 0.9792 | 0.3750 | |
| LY2 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 10264.001 | uM | 1.5220 | 12.28790 | -0.5051 | -1.0000 | 0.5260 | 0.3393 | 0.7954 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK1070916 | AURK | AURK | 10264.001 | uM | 9.11390 | 14.85550 | -0.7214 | -0.9999 | 2.2485 | 0.1714 | 0.9881 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 10264.001 | uM | 2.16170 | 56.86920 | -0.0483 | -1.0000 | 0.3360 | 0.2627 | 0.8398 | 1.5356 | |
| LY2 | HR+ | Luminal | Docetaxel | TUBB | TUBB | 10264.002 | uM | 0.00945 | 0.00756 | 0.1452 | 0.1345 | 1.4084 | 0.4669 | 0.9869 | 1.2356 | |
| LY2 | HR+ | Luminal | Taxol | TUBB | TUBB | 10264.002 | uM | 0.01167 | 0.01092 | -0.1629 | 0.0626 | 1.9986 | 0.5515 | 0.9562 | 1.2356 | |
| LY2 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 10264.011 | uM | 0.01515 | 0.00980 | 0.4029 | 0.4434 | 5.0000 | 0.4053 | 0.9814 | 1.3983 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10264.011 | uM | 53.18280 | 98.53430 | -0.6128 | -0.6689 | 1.3771 | 0.3634 | 0.9946 | 1.3983 |