Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | PD173074 | FGFR1/3 | RTK | 5898.093 | uM | 7.82560 | 10.48720 | -0.9800 | -1.0000 | 3.7527 | 0.3030 | 0.9267 | 0.6963 | |
| 600MPE | HR+ | Luminal | PD 98059 | MEK | MAPK | 12224.152 | uM | 124.1750 | 739.75820 | 0.6747 | -1.0000 | 0.6156 | 0.0605 | 0.8626 | 1.0761 | |
| 600MPE | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 12224.147 | uM | 2.79220 | 7.38130 | -0.9880 | -1.0000 | 1.1301 | 0.3828 | 0.9872 | 0.8621 | |
| 600MPE | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9120.021 | uM | 16.89330 | 40.58020 | -0.9570 | -1.0000 | 1.2536 | 0.4435 | 0.9886 | 0.6486 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5894.095 | uM | 53.72510 | 62.72890 | -0.1792 | -0.0920 | 1.0901 | 0.3508 | 0.940 | 1.7133 | |
| 600MPE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 5898.086 | uM | 0.00518 | 0.03234 | -0.9192 | -0.9919 | 0.5968 | 1.0821 | 0.9909 | 0.5904 | |
| 600MPE | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 12224.147 | uM | 5.58170 | 10.43060 | -0.8385 | -0.8767 | 1.6199 | 0.4077 | 0.9941 | 0.8621 | |
| 600MPE | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 5898.066 | uM | 21.57430 | 55.22930 | -0.1137 | -1.0000 | 1.1687 | 0.2041 | 0.8254 | 0.6097 | |
| 184A1 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 9047.011 | uM | 0.39288 | 3.58790 | -0.7197 | -1.0000 | 0.4967 | 0.6665 | 0.9520 | 0.6293 | |
| 600MPE | HR+ | Luminal | NU6102 | CDK1/2 | CDK | 12224.147 | uM | 13.35890 | 16.51910 | -0.9366 | -0.9385 | 4.9766 | 0.1740 | 0.9959 | 0.8621 | |
| 600MPE | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 12224.152 | uM | 3.0690 | 3.80580 | -0.9666 | -0.9662 | 5.0000 | 0.6239 | 0.9973 | 1.0761 | |
| 600MPE | HR+ | Luminal | Nilotinib | ABL | nRTK | 12224.145 | uM | inf | inf | 0.9894 | 0.9894 | 0.0000 | -0.0249 | -0.6099 | 0.9737 | |
| 600MPE | HR+ | Luminal | Nelfinavir | 13091.174 | uM | 7.89670 | 11.89710 | -0.8885 | -1.0000 | 2.6806 | 0.2337 | 0.9761 | 0.7967 | |||
| 184B5 | NM | Basal | Imatinib | ABL/KIT/PDGFR | nRTK | 5897.091 | uM | 24.73780 | 35.23660 | -0.9547 | -0.9568 | 3.0230 | 0.4186 | 0.9990 | 1.2296 | |
| 600MPE | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 12224.145 | uM | 0.48313 | 0.59815 | -0.9678 | -0.9541 | 4.9993 | 0.6869 | 0.9988 | 0.9737 | |
| 600MPE | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 12224.145 | uM | 0.48313 | 0.59815 | -0.9678 | -0.9541 | 4.9993 | 0.6869 | 0.9988 | 0.9737 | |
| 600MPE | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14197.189 | uM | 0.51937 | 0.56031 | -0.0819 | -0.2307 | 5.0000 | 0.4836 | 0.9433 | 1.3593 | |
| 600MPE | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14197.189 | uM | 0.51937 | 0.56031 | -0.0819 | -0.2307 | 5.0000 | 0.4836 | 0.9433 | 1.3593 | |
| 600MPE | HR+ | Luminal | Methylglyoxal | 13091.184 | uM | 541.6520 | 823.99310 | -0.9999 | -0.9709 | 2.5719 | 0.6677 | 0.9952 | 0.8014 | |||
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 5898.085 | uM | 0.04275 | 0.02134 | 0.1899 | 0.2364 | 0.9210 | 0.5707 | 0.9492 | 0.7048 | |
| 600MPE | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 5899.084 | uM | inf | 124.59710 | 0.7402 | 0.5425 | 0.2308 | 0.1158 | 0.6762 | 1.1144 | |
| 600MPE | HR+ | Luminal | Mebendazole | 13091.174 | uM | 14.64610 | 480.70650 | 0.3243 | -1.0000 | 0.3147 | 0.2245 | 0.8786 | 0.7967 | |||
| 600MPE | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12224.154 | uM | 1.54780 | 2.65610 | -0.9808 | -0.9927 | 2.0253 | 0.4248 | 0.9948 | 0.9590 | |
| 184B5 | NM | Basal | GW-5074 | CRAF | MAPK | 5897.088 | uM | 2.70550 | 3.11820 | -0.1725 | -0.1816 | 2.1826 | 0.2410 | 0.9894 | 1.2950 | |
| 600MPE | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 5899.098 | uM | inf | 43.7290 | 0.7237 | 0.4664 | 0.1327 | 0.1531 | 0.7519 | 1.1012 |