Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Cisplatin | DNA cross-linker | DNA cross-linker | 9860.017 | uM | 5.30820 | 6.87760 | -0.5188 | -0.4096 | 2.3102 | 0.3798 | 0.9912 | 1.7158 | |
| SUM229PE | TNBC | - | Dichloroacetate | PDK | PDK | 13062.176 | uM | inf | inf | 0.9532 | 0.9532 | 0.0000 | 0.0274 | 0.1104 | 1.7805 | |
| SUM229PE | TNBC | - | CPT-11 | TOP1 | TOP | 7536.078 | uM | 7.97920 | 15.39450 | -0.8434 | -0.9572 | 1.6277 | 0.2597 | 0.9947 | 1.1676 | |
| SUM229PE | TNBC | - | Dactolisib | PI3K | PI3K | 11058.155 | uM | 0.25793 | 0.15320 | 0.3078 | 0.3817 | 2.7666 | 0.2771 | 0.7922 | 2.0706 | |
| SUM229PE | TNBC | - | Etoposide | TOP2 | TOP | 7535.074 | uM | 0.7680 | 1.77280 | -0.8127 | -0.7914 | 1.1343 | 0.7541 | 0.9949 | 1.0507 | |
| SUM229PE | TNBC | - | Epirubicin | TOP2 | TOP | 9860.017 | uM | 0.25418 | 0.41053 | -0.9694 | -0.4570 | 1.3542 | 0.6519 | 0.8910 | 1.7158 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 13009.174 | uM | 15.01220 | 22.51350 | -0.9124 | -1.0000 | 2.7109 | 0.2119 | 0.9846 | 1.4104 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| SUM229PE | TNBC | - | Doxorubicin | TOP2 | TOP | 7536.078 | uM | 0.18894 | 0.22944 | -0.4815 | -0.4134 | 3.1024 | 0.6315 | 0.9970 | 1.1676 | |
| 21MT-1 | HER2amp | - | Dichloroacetate | PDK | PDK | 13719.176 | uM | inf | inf | 0.9233 | 0.9233 | 0.0000 | 0.0596 | -0.2426 | 0.8672 | |
| SUM229PE | TNBC | - | Doxorubicin | TOP2 | TOP | 9860.121 | uM | 0.22626 | 0.25511 | -0.3436 | -0.1308 | 1.9356 | 0.5100 | 0.9656 | 1.7546 | |
| 21MT-1 | HER2amp | - | Disulfiram | Proteasome | Proteasome | 13719.174 | uM | inf | 0.02944 | 0.8637 | 0.8697 | 4.9974 | 0.0852 | 0.6419 | 0.8124 | |
| SUM229PE | TNBC | - | Docetaxel | TUBB | TUBB | 9860.002 | uM | 0.00390 | 0.00430 | -0.1347 | -0.1014 | 1.9159 | 0.6524 | 0.9980 | 1.5734 | |
| SUM229PE | TNBC | - | Docetaxel | TUBB | TUBB | 13009.002 | uM | 0.01277 | 0.0140 | -0.0696 | -0.0680 | 1.3807 | 0.5481 | 0.9961 | 1.3417 | |
| SUM229PE | TNBC | - | Docetaxel | TUBB | TUBB | 13062.002 | uM | 0.01265 | 0.01189 | 0.0675 | 0.0500 | 1.6910 | 0.4907 | 0.9973 | 1.6470 | |
| SUM229PE | TNBC | - | Erlotinib | EGFR | ErbB | 7537.091 | uM | 28.06160 | 33.68310 | 0.4130 | -0.0340 | 0.3606 | 0.1825 | 0.9730 | 2.0227 | |
| SUM229PE | TNBC | - | Erlotinib | EGFR | ErbB | 7536.09 | uM | inf | inf | 0.4561 | 0.4561 | 0.0000 | 0.2955 | 0.4278 | 1.1257 | |
| 21MT-1 | HER2amp | - | Mebendazole | 13719.174 | uM | 31.97060 | 77.55140 | 0.0875 | -1.0000 | 1.2398 | 0.1610 | 0.8782 | 0.8124 | |||
| 21MT-1 | HER2amp | - | Methylglyoxal | 13719.184 | uM | 680.32080 | 999.99990 | -0.9954 | -0.9645 | 2.7899 | 0.6345 | 0.9961 | 0.7600 | |||
| SUM229PE | TNBC | - | Erlotinib | EGFR | ErbB | 7535.092 | uM | 4.99350 | 105.27110 | 0.1007 | -1.0000 | 0.3604 | 0.2420 | 0.8485 | 1.1267 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 14191.189 | uM | inf | inf | -0.1161 | -0.1161 | 0.0000 | 0.5482 | 0.5418 | 2.9704 |