Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7893.05 | uM | 1.95060 | 1.91370 | -0.0860 | 0.0152 | 1.6165 | 0.2775 | 0.9811 | 2.2255 | |
| MCF 10A | NM | Basal B | 17-AAG | HSP90 | HSP90 | 7870.037 | uM | 0.04563 | 0.06075 | -0.5691 | -0.4296 | 2.1655 | 0.8195 | 0.9896 | 2.2561 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 7825.05 | uM | 0.19710 | 0.29708 | -0.4272 | -0.2349 | 0.9388 | 0.5258 | 0.9530 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 9347.037 | uM | 0.14895 | 0.26760 | -0.4151 | -0.3269 | 0.8586 | 0.5965 | 0.9831 | 1.5927 | |
| MDA-MB-175-VII | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7885.05 | uM | 0.01442 | 0.02938 | -0.8685 | -0.6928 | 1.2214 | 1.0607 | 0.9817 | 0.6518 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 9797.037 | uM | 0.01326 | 0.02914 | -1.0000 | -0.7749 | 1.1894 | 1.0997 | 0.9485 | 0.3871 | |
| HBL-100 | Unknown | Unknown | 17-AAG | HSP90 | HSP90 | 7807.04 | uM | 1.67060 | 4.14870 | -0.7759 | -0.7682 | 1.0232 | 0.4211 | 0.9891 | 2.1435 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7892.037 | uM | 2.09540 | 2.01480 | -0.0092 | 0.0346 | 1.8304 | 0.2984 | 0.9940 | 2.5183 | |
| MCF 10A | NM | Basal B | 17-AAG | HSP90 | HSP90 | 7867.04 | uM | 0.04721 | 0.06362 | -0.7283 | -0.4910 | 2.2943 | 0.8338 | 0.9815 | 2.4460 | |
| MDA-MB-175-VII | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7886.04 | uM | 0.05273 | 0.06706 | -0.7856 | -0.6085 | 3.3117 | 0.9362 | 0.9853 | 0.7771 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7896.04 | uM | 0.09913 | 0.11658 | -0.6645 | -0.6245 | 4.9993 | 0.8601 | 0.9983 | 1.0776 | |
| HCC1954 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 7836.05 | uM | 0.05442 | 0.07004 | -0.7216 | -0.5172 | 2.8151 | 0.8537 | 0.9834 | 1.4789 | |
| CAMA-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7805.05 | uM | 0.33059 | 0.62314 | -0.2532 | -0.2197 | 0.5745 | 0.4652 | 0.9470 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9210.037 | uM | 0.17414 | 0.82088 | -0.7513 | -0.7575 | 0.5948 | 0.6396 | 0.9590 | 0.8166 | |
| MDA-MB-175-VII | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7885.037 | uM | 0.03688 | 0.05497 | -0.8073 | -0.6731 | 2.1373 | 0.9690 | 0.9919 | 0.6907 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7505.05 | uM | 0.06877 | 0.08306 | -0.8520 | -0.7858 | 5.0000 | 0.9896 | 0.9983 | 0.9037 | |
| MCF 10A | NM | Basal B | 17-AAG | HSP90 | HSP90 | 9551.037 | uM | 0.04202 | 0.05568 | -0.6021 | -0.4517 | 2.2857 | 0.8285 | 0.9921 | 2.6200 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 10266.037 | uM | 0.31469 | 3.51830 | -0.8011 | -1.0000 | 0.4551 | 0.5489 | 0.9312 | 0.7695 | |
| Hs 578T | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7864.037 | uM | 0.12650 | 0.16117 | -0.3959 | -0.3057 | 1.9692 | 0.6470 | 0.9950 | 1.7830 | |
| HCC70 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7860.04 | uM | 0.34657 | 0.65539 | -0.9301 | -0.7145 | 1.3929 | 0.6411 | 0.9795 | 0.7003 | |
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 9469.037 | uM | 0.09572 | 0.14148 | -0.6467 | -0.4348 | 1.6015 | 0.6945 | 0.9754 | 1.0663 | |
| Hs 578T | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7864.05 | uM | 0.09689 | 0.12009 | -0.5415 | -0.4141 | 2.8102 | 0.7319 | 0.990 | 1.5353 | |
| MDA-MB-453 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 9708.037 | uM | 0.02961 | 0.04484 | -0.9502 | -0.5888 | 1.8753 | 0.9195 | 0.9619 | 1.1319 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9146.037 | uM | 0.15634 | 3.69020 | -0.9186 | -1.0000 | 0.3475 | 0.5819 | 0.8060 | 1.2617 | |
| MDA-MB-436 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7900.037 | uM | inf | inf | -0.8433 | -0.8433 | 0.0000 | 0.8378 | 0.4634 | 0.6692 |