Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9421.021 | uM | 1.64960 | 2.88290 | -1.0000 | -0.9906 | 1.9565 | 0.6753 | 0.9969 | 0.3726 | |
| SUM1315MO2 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9797.017 | uM | 0.92127 | 2.12350 | -1.0000 | -1.0000 | 1.3156 | 0.7710 | 0.9823 | 0.4824 | |
| HCC1187 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7811.017 | uM | 1.68090 | 2.53690 | -1.0000 | -1.0000 | 2.6690 | 0.9047 | 0.7309 | 0.3604 | |
| HCC1187 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 9244.021 | uM | 2.02180 | 2.59060 | -1.0000 | -0.9970 | 4.4235 | 0.7319 | 0.9785 | 0.4542 | |
| HCC1187 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 7811.017 | uM | 0.08798 | 0.25888 | -1.0000 | -1.0000 | 1.0180 | 1.0515 | 0.9521 | 0.3604 | |
| HCC38 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10268.12 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 1.2668 | 0.5308 | 0.3272 | |
| MDA-MB-453 | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 9708.006 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 1.6076 | 0.3995 | 0.6313 | |
| LY2 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7477.071 | uM | 0.62597 | 1.35510 | -1.0000 | -0.9841 | 1.4086 | 0.6625 | 0.9893 | 0.5122 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10643.087 | uM | 0.00172 | 0.00488 | -1.0000 | -0.9991 | 1.0559 | 1.3640 | 0.9987 | 0.6516 | |
| HCC1187 | TNBC | Basal A | Methylglyoxal | 13726.184 | uM | 0.99124 | 16.40040 | -1.0000 | -1.0000 | 0.3915 | 1.2606 | 0.7991 | 0.3574 | |||
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10643.142 | uM | 0.20699 | 0.79038 | -1.0000 | -1.0000 | 0.8199 | 0.7668 | 0.9906 | 0.5166 | |
| HCC1187 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7811.011 | uM | 0.26894 | 0.77535 | -1.0000 | -1.0000 | 1.0376 | 1.1173 | 0.9558 | 0.4400 | |
| MX1 | Unknown | Unknown | Bromopyruvic acid | Hexokinase II | Metabolism | 12667.177 | uM | 0.02030 | 0.02529 | -1.0000 | -1.0000 | 5.0000 | 1.1110 | 0.9986 | 0.5892 | |
| HCC2185 | TNBC | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7848.011 | uM | 3.65840 | 8.42860 | -1.0000 | -1.0000 | 1.3163 | 0.6851 | 0.9953 | 0.3405 | |
| SUM1315MO2 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 9044.067 | uM | 0.05573 | 1.21580 | -1.0000 | -1.0000 | 0.3564 | 0.8720 | 0.5906 | 0.3210 | |
| MX1 | Unknown | Unknown | Olomoucine II | CDK1 | CDK | 10644.147 | uM | 6.00730 | 7.48350 | -1.0000 | -1.0000 | 5.0000 | 0.4357 | 0.9851 | 0.4349 | |
| Hs 578T | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7471.092 | uM | 3.33160 | 4.13810 | -1.0000 | -0.9781 | 5.0000 | 0.8415 | 0.9628 | 0.3860 | |
| BT-474 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 9163.121 | uM | 0.18301 | 0.22105 | -1.0000 | -0.7856 | 5.0000 | 0.7812 | 0.9752 | 0.4382 | |
| HCC2185 | TNBC | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9421.021 | uM | 3.32830 | 5.08560 | -1.0000 | -0.9677 | 2.5400 | 0.7050 | 0.9975 | 0.3726 | |
| HCC38 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 10268.12 | uM | 0.41958 | 0.88930 | -1.0000 | -0.9927 | 1.4560 | 1.1119 | 0.9972 | 0.3272 | |
| HCC1395 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9258.026 | uM | 0.44087 | 35.50130 | -1.0000 | -1.0000 | 0.2503 | 0.8247 | 0.7494 | 0.5632 | ||
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9258.03 | uM | 1.05110 | 2.06760 | -1.0000 | -1.0000 | 1.6238 | 0.7227 | 0.9985 | 0.4015 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9254.001 | uM | 5.38610 | 6.70950 | -1.0000 | -0.9998 | 5.0000 | 0.3079 | 0.9082 | 0.3986 |