Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 7506.066 | uM | inf | inf | 0.9368 | 0.9368 | 0.0000 | 0.0689 | 0.0388 | 1.1486 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10999.151 | uM | inf | inf | 0.6771 | 0.6771 | 0.0000 | 0.0774 | 0.0387 | 0.7090 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 11936.157 | uM | inf | inf | 0.7052 | 0.7052 | 0.0000 | 0.1856 | -0.0376 | 0.9133 | |
| MDA-MB-361 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7895.018 | uM | inf | inf | 0.9756 | 0.9756 | 0.0000 | 0.0240 | -0.0375 | 1.2916 | |
| MDA-MB-134-VI | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10519.137 | uM | inf | inf | 0.8748 | 0.8748 | 0.0000 | 0.0872 | -0.0369 | 1.0772 | |
| BT-474 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 12291.155 | uM | inf | inf | 0.8945 | 0.8945 | 0.0000 | -0.0163 | 0.0368 | 0.4532 | |
| MDA-MB-175-VII | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10642.139 | uM | inf | inf | 0.8934 | 0.8934 | 0.0000 | 0.0557 | -0.0365 | 0.7017 | |
| Hs 578T | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 10694.154 | uM | inf | inf | 0.9764 | 0.9764 | 0.0000 | -0.0084 | -0.0364 | 2.3045 | |
| HCC1428 | HR+ | Luminal | PD184352 | MEK | MAPK | 11936.155 | uM | inf | inf | 0.9166 | 0.9166 | 0.0000 | 0.0264 | -0.0360 | 0.7332 | |
| HCC1428 | HR+ | Luminal | PD184352 | MEK | MAPK | 11936.155 | uM | inf | inf | 0.9166 | 0.9166 | 0.0000 | 0.0264 | -0.0360 | 0.7332 | |
| BT-474 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 12178.16 | uM | inf | inf | 0.7508 | 0.7508 | 0.0000 | 0.1609 | 0.0357 | 0.7392 | ||
| MDA-MB-453 | TNBC | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7517.084 | uM | inf | inf | 0.8484 | 0.8484 | 0.0000 | 0.1100 | -0.0346 | 1.4076 | |
| MCF7 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9583.026 | uM | inf | inf | 0.9966 | 0.9966 | 0.0000 | 0.0156 | -0.0344 | 1.2731 | |
| HCC1419 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7437.084 | uM | inf | inf | 0.9273 | 0.9273 | 0.0000 | 0.1333 | 0.0343 | 0.4343 | |
| ZR-75-1 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 12003.167 | uM | inf | inf | 0.7304 | 0.7304 | 0.0000 | 0.2250 | -0.0343 | 1.1158 | |
| 600MPE | HR+ | Luminal | GM6001 | MMP | MMP | 5898.096 | uM | inf | inf | 0.8794 | 0.8794 | 0.0000 | 0.0460 | -0.0341 | 0.6718 | |
| MB 157 | Unknown | Unknown | AG1024 | IGF1R | RTK | 7482.066 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0332 | -0.0335 | 1.1347 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 7906.012 | uM | inf | inf | 0.2629 | 0.2629 | 0.0000 | 0.1652 | -0.0328 | 0.4916 | |
| SUM190PT | HER2amp | Luminal | Ribavirin | 15358.211 | uM | inf | inf | 1.0036 | 1.0036 | 0.0000 | -0.0073 | -0.0327 | 1.3504 | |||
| Hs 578T | TNBC | Basal B | PD 98059 | MEK | MAPK | 10694.152 | uM | inf | inf | 0.8155 | 0.8155 | 0.0000 | 0.0947 | 0.0324 | 2.4238 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 5902.084 | uM | inf | inf | 0.9945 | 0.9945 | 0.0000 | -0.0077 | -0.0317 | 1.3532 | |
| HCC1569 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 7447.102 | uM | inf | inf | 0.9613 | 0.9613 | 0.0000 | 0.0386 | 0.0310 | 1.6467 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 12084.154 | uM | inf | inf | 0.7715 | 0.7715 | 0.0000 | 0.1395 | -0.0309 | 1.2963 | |
| CAMA-1 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 5912.067 | uM | inf | inf | 0.8672 | 0.8672 | 0.0000 | 0.0876 | -0.0304 | 1.1725 | |
| CAMA-1 | HR+ | Luminal | Nilotinib | ABL | nRTK | 12070.145 | uM | inf | inf | 0.8990 | 0.8990 | 0.0000 | 0.1345 | 0.0301 | 1.0737 |