Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 12126.144 | uM | inf | inf | 0.4468 | 0.4468 | 0.0000 | 0.2552 | 0.5580 | 0.6379 | |
| 21MT-1 | HER2amp | - | Dichloroacetate | PDK | PDK | 13719.176 | uM | inf | inf | 0.9233 | 0.9233 | 0.0000 | 0.0596 | -0.2426 | 0.8672 | |
| SUM190PT | HER2amp | Luminal | Ribavirin | 15358.211 | uM | inf | inf | 1.0036 | 1.0036 | 0.0000 | -0.0073 | -0.0327 | 1.3504 | |||
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 12000.155 | uM | inf | inf | 0.6675 | 0.6675 | 0.0000 | 0.2919 | 0.2735 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 12084.155 | uM | inf | inf | 0.8548 | 0.8548 | 0.0000 | 0.1129 | 0.4499 | 1.2955 | |
| MCF7 | HR+ | Luminal | Dichloroacetate | PDK | PDK | 12657.176 | uM | inf | inf | 0.9410 | 0.9410 | 0.0000 | 0.0143 | 0.5190 | 1.0711 | |
| HCC1395 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 13538.176 | uM | inf | inf | 0.8042 | 0.8042 | 0.0000 | 0.1436 | 0.3146 | 0.4572 | |
| Hs 578T | TNBC | Basal B | GSK1838705A | IGF1R | RTK | 7475.07 | uM | inf | inf | 0.4928 | 0.4928 | 0.0000 | 0.0421 | 0.3563 | 2.7378 | |
| MDA-MB-134-VI | HR+ | Luminal | L-779450 | BRAF | MAPK | 10519.137 | uM | inf | inf | 0.7146 | 0.7146 | 0.0000 | 0.0702 | 0.5660 | 1.0772 | |
| MCF 10A | NM | Basal B | AS-252424 | PI3K | PI3K | 11056.158 | uM | inf | inf | 0.3950 | 0.3950 | 0.0000 | 0.0612 | 0.4274 | 2.7355 | |
| HCC1395 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 7816.007 | uM | inf | inf | 0.3187 | 0.3187 | 0.0000 | 0.2775 | 0.3760 | 1.1536 | |
| HCC1395 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7816.017 | uM | inf | inf | 0.6386 | 0.6386 | 0.0000 | 0.2394 | 0.3980 | 1.2318 | |
| HCC2185 | TNBC | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7464.095 | uM | inf | inf | 0.9059 | 0.9059 | 0.0000 | -0.0281 | -0.2886 | 0.5464 | |
| MDA-MB-157 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14218.189 | uM | inf | inf | -0.3389 | -0.3389 | 0.0000 | 0.6358 | 0.5723 | 1.3111 | |
| MDA-MB-436 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7900.017 | uM | inf | inf | -0.7673 | -0.7673 | 0.0000 | 0.4436 | 0.5715 | 0.5383 | |
| MDA-MB-415 | HR+ | Luminal | Dichloroacetate | PDK | PDK | 12959.176 | uM | inf | inf | 0.7219 | 0.7219 | 0.0000 | 0.2500 | -1.1239 | 0.5779 | |
| BT-20 | TNBC | Basal A | Pertuzumab | 5903.102 | mg/ml | inf | inf | 0.9324 | 0.9324 | 0.0000 | -0.0074 | -0.0405 | 1.2557 | |||
| MDA-MB-175-VII | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7884.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.6074 | |
| HCC2185 | TNBC | Luminal | PD184352 | MEK | MAPK | 12192.155 | uM | inf | inf | 0.7159 | 0.7159 | 0.0000 | 0.2130 | 0.0390 | 0.7451 | |
| MDA-MB-361 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7895.018 | uM | inf | inf | 0.9756 | 0.9756 | 0.0000 | 0.0240 | -0.0375 | 1.2916 | |
| HCC70 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 12400.167 | uM | inf | inf | 1.0329 | 1.0329 | 0.0000 | 0.0088 | 0.0000 | 1.2627 | |
| HCC1395 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 12000.167 | uM | inf | inf | 0.7814 | 0.7814 | 0.0000 | 0.1511 | -0.0746 | 0.7185 | |
| SUM225CWN | HER2amp | Basal A | Celecoxib | COX2 | COX | 10579.136 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.6876 | |
| SUM225CWN | HER2amp | Basal A | Chk2 inhibitor II | CHK2 | CHK | 10579.14 | uM | inf | inf | 0.6784 | 0.6784 | 0.0000 | 0.0743 | 0.2850 | 0.9303 | |
| SUM225CWN | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 12098.155 | uM | inf | inf | 0.5885 | 0.5885 | 0.0000 | 0.3880 | 0.4982 | 1.0503 |