Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12291.169 | uM | 6.18190 | 14.50510 | -0.9859 | -1.0000 | 1.2881 | 0.3744 | 0.9158 | 0.3548 | |
| AU565 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5900.098 | uM | 1.68930 | 2.73370 | -0.8099 | -0.7858 | 1.9622 | 0.4216 | 0.9981 | 2.2937 | |
| BT-474 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 5905.093 | uM | inf | inf | 0.8892 | 0.8892 | 0.0000 | -0.0060 | 0.0525 | 0.9101 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9157.012 | uM | inf | inf | 0.7933 | 0.7933 | 0.0000 | 0.0840 | 0.4934 | 0.8641 | |
| AU565 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5901.098 | uM | 2.47210 | 4.04280 | -0.8645 | -0.8719 | 2.0519 | 0.4223 | 0.9988 | 1.8013 | |
| BT-474 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9163.024 | uM | 44.54640 | 122.93040 | 0.7877 | -0.9791 | 1.0684 | 0.0080 | 0.7001 | 0.5524 | |
| 21MT-1 | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14779.203 | uM | 2.22370 | 3.73670 | -0.7373 | -0.7957 | 1.8347 | 0.4364 | 0.9894 | 1.9695 | |
| BT-474 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9158.123 | uM | 0.01277 | 0.00885 | -0.0100 | 0.0993 | 0.6043 | 0.4533 | 0.9046 | 0.8769 | |
| AU565 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9035.001 | uM | 0.00071 | 0.00076 | 0.2153 | -0.1767 | 5.0000 | 0.9858 | 0.7915 | 2.4291 | |
| BT-474 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9163.026 | uM | 0.00135 | 0.0020 | -0.6688 | -0.4240 | 1.5559 | 0.8993 | 0.9648 | 0.3738 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5906.065 | uM | 7.71060 | 10.80850 | -0.9938 | -0.9980 | 3.2489 | 0.9661 | 0.9945 | 0.6586 | |
| AU565 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9146.001 | uM | 0.01119 | 0.01274 | -0.9678 | -0.4577 | 5.0000 | 0.8676 | 0.8304 | 1.2878 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5905.065 | uM | 10.69090 | 15.04820 | -0.9632 | -0.9609 | 3.1364 | 0.8807 | 0.9976 | 0.8461 | |
| 21MT-1 | HER2amp | - | Dichloroacetate | PDK | PDK | 13719.176 | uM | inf | inf | 0.9233 | 0.9233 | 0.0000 | 0.0596 | -0.2426 | 0.8672 | |
| BT-474 | HER2amp | Luminal | Triciribine | AKT | AKT | 5906.074 | uM | 0.01550 | 0.02634 | -0.2986 | -0.2004 | 0.6357 | 0.6325 | 0.9018 | 0.6442 | |
| AU565 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7793.001 | uM | 0.01232 | 0.01448 | -0.9105 | -0.6208 | 5.0000 | 0.9168 | 0.9189 | 1.1508 | |
| BT-474 | HER2amp | Luminal | Triciribine | AKT | AKT | 5905.074 | uM | 0.07957 | 0.15194 | -0.2667 | -0.3062 | 0.7386 | 0.5707 | 0.9369 | 0.8648 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 12178.143 | uM | 463.94180 | 1000.00000 | -0.9713 | -0.7580 | 1.2014 | 0.4048 | 0.9150 | 0.7617 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9146.001 | uM | 0.02033 | 0.02649 | -0.8927 | -0.5587 | 2.8328 | 0.8586 | 0.9418 | 1.2878 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 12056.143 | uM | 391.07680 | 1000.00000 | -0.9342 | -0.7776 | 0.9992 | 0.3918 | 0.9185 | 1.0075 | |
| 21MT-1 | HER2amp | - | Disulfiram | Proteasome | Proteasome | 13719.174 | uM | inf | 0.02944 | 0.8637 | 0.8697 | 4.9974 | 0.0852 | 0.6419 | 0.8124 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 12291.143 | uM | 717.16620 | 1000.00000 | -0.9964 | -0.7984 | 2.8704 | 0.3234 | 0.9803 | 0.5621 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9035.001 | uM | 0.02298 | 0.02665 | -0.0875 | -0.2211 | 2.4716 | 0.6936 | 0.9681 | 2.4291 | |
| BT-474 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7798.018 | uM | 0.07033 | 1.33570 | -0.8933 | -1.0000 | 0.3732 | 0.6131 | 0.8869 | 1.4461 |