Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.107 | uM | 13062.174 | 0.9737 | 0.9683 | 1.6688 | |
| SUM229PE | TNBC | - | Disulfiram | Proteasome | Proteasome | 0.533 | uM | 13062.174 | 0.9808 | 0.9768 | 1.6688 | |
| SUM229PE | TNBC | - | AG1478 | EGFR | ErbB | 167 | uM | 7536.016 | 0.6054 | -0.0855 | 0.6413 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 0.0213 | uM | 14191.189 | 0.9788 | 0.9856 | 2.9704 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 0.107 | uM | 14191.189 | 0.5494 | 0.6348 | 2.9704 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 0.107 | uM | 14191.189 | 0.5494 | 0.6348 | 2.9704 | |
| SUM229PE | TNBC | - | AG1478 | EGFR | ErbB | 33.3 | uM | 7536.016 | 0.4620 | -0.4001 | 0.6413 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 2.67 | uM | 14191.189 | 0.0046 | -0.6729 | 2.9704 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 13.3 | uM | 14191.189 | 0.0884 | -0.1161 | 2.9704 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 13.3 | uM | 14191.189 | 0.0884 | -0.1161 | 2.9704 | |
| SUM229PE | TNBC | - | AG1478 | EGFR | ErbB | 0.0107 | uM | 9860.019 | 0.9942 | 0.9932 | 1.6927 | |
| SUM229PE | TNBC | - | AG1478 | EGFR | ErbB | 33.3 | uM | 9860.019 | 0.7897 | 0.7397 | 1.6927 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 0.000853 | uM | 14607.189 | 0.8605 | 0.7928 | 1.3733 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 0.00427 | uM | 14607.189 | 0.9713 | 0.9581 | 1.3733 | |
| SUM229PE | TNBC | - | AG1478 | EGFR | ErbB | 0.00213 | uM | 9860.019 | 0.8735 | 0.8465 | 1.6927 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 0.0213 | uM | 14607.189 | 0.9407 | 0.9129 | 1.3733 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 0.107 | uM | 14607.189 | 0.6416 | 0.4477 | 1.3733 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 0.533 | uM | 14607.189 | 0.1481 | -0.5022 | 1.3733 | |
| SUM229PE | TNBC | - | AG1478 | EGFR | ErbB | 6.67 | uM | 9860.019 | 0.6934 | 0.6110 | 1.6927 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 13.3 | uM | 14607.189 | 0.0212 | -0.8793 | 1.3733 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 66.7 | uM | 14607.189 | 0.0157 | -0.9029 | 1.3733 | |
| 21MT-1 | HER2amp | - | MG-132 | Proteasome | Proteasome | 66.7 | uM | 14607.189 | 0.0157 | -0.9029 | 1.3733 | |
| SUM229PE | TNBC | - | AG1478 | EGFR | ErbB | 0.0533 | uM | 9860.019 | 0.9615 | 0.9541 | 1.6927 | |
| MCF 10F | NM | - | TCS PIM-1 1 | Pim kinase | PIM | 0.213 | uM | 12254.135 | 1.0002 | 1.0003 | 1.6637 | |
| MCF 10F | NM | - | TCS PIM-1 1 | Pim kinase | PIM | 0.0427 | uM | 12254.135 | 0.9827 | 0.9792 | 1.6637 |