Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9047.001 | 0.9657 | 0.9114 | 0.7701 | |
| 184B5 | NM | Basal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9095.001 | 1.0160 | 1.0306 | 1.0444 | |
| MDA-MB-453 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12414.165 | 1.0242 | 1.0388 | 1.2459 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7552.066 | 0.9955 | 0.9912 | 1.0180 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7793.001 | 1.0185 | 1.0321 | 1.1508 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10644.146 | 1.0316 | 1.1070 | 0.5967 | |
| AU565 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9035.001 | 0.8828 | 0.9000 | 2.4291 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12220.155 | 1.0007 | 1.0028 | 0.4858 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9157.001 | 1.0622 | 1.1355 | 0.9211 | |
| SUM149PT | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 0.0000853 | uM | 10819.15 | 1.0243 | 1.0227 | 2.1256 | ||
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7798.001 | 1.0502 | 1.0729 | 1.3667 | |
| HCC1569 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0000853 | uM | 10872.154 | 0.9962 | 0.9946 | 1.3976 | |
| SUM185PE | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12269.165 | 1.4328 | 2.6416 | 0.6001 | |
| HCC2185 | TNBC | Luminal | FTase Inhibitor I | Ftase | MAPK | 0.0000853 | uM | 12192.154 | 1.0587 | 1.2237 | 0.5377 | |
| HCC38 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.0000853 | uM | 11850.154 | 0.9290 | 0.9244 | 1.9115 | |
| ZR-75-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7553.066 | 0.9906 | 0.9806 | 0.9707 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7896.001 | 1.0192 | 1.0322 | 1.1912 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7906.001 | 0.8410 | 0.4747 | 0.5685 | |
| HCC38 | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 0.0000853 | uM | 10578.142 | 0.8614 | 0.8418 | 1.8112 | |
| SUM159PT | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10520.137 | 1.0977 | 1.0499 | 3.7823 | |
| HCC38 | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 10418.066 | 1.0341 | 1.0589 | 1.1532 | |
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10816.155 | 1.0550 | 1.1323 | 0.8353 | |
| HCC1187 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9244.001 | 1.1115 | 1.4307 | 0.5421 | |
| SUM185PE | TNBC | Luminal | Nelfinavir | 0.0000853 | uM | 13140.174 | 0.9652 | 0.8809 | 0.5769 | |||
| HCC1187 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0000853 | uM | 10753.154 | 1.0483 | 1.0664 | 1.4444 |