Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 1.33 | uM | 10816.15 | 1.0809 | 1.5848 | 0.3031 | |
| LY2 | HR+ | Luminal | ZM-447439 | AURK | AURK | 0.000427 | uM | 10816.15 | 1.4618 | 5.9987 | 0.3031 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 15000 | uM | 10996.143 | 0.0280 | -1.0000 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Ibandronate | FDPS | 0.00384 | uM | 10996.143 | 1.0161 | 1.1084 | 0.3034 | ||
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 0.064 | uM | 10996.143 | 0.9653 | 0.7805 | 0.3034 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 0.0128 | uM | 10996.143 | 0.9593 | 0.7440 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Ibandronate | FDPS | 0.0192 | uM | 10996.143 | 1.0204 | 1.1376 | 0.3034 | ||
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 120 | uM | 10996.143 | 0.9970 | 0.9803 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 24 | uM | 10996.143 | 0.9336 | 0.5948 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 600 | uM | 10996.143 | 0.8827 | 0.3259 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 0.96 | uM | 10996.143 | 1.0222 | 1.1501 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Ibandronate | FDPS | 0.096 | uM | 10996.143 | 1.0074 | 1.0495 | 0.3034 | ||
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 0.192 | uM | 10996.143 | 0.9585 | 0.7390 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 4.8 | uM | 10996.143 | 1.0151 | 1.1013 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 3000 | uM | 10996.143 | 0.6087 | -0.6104 | 0.3034 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 1000 | uM | 10996.143 | 0.7662 | -0.1686 | 0.3034 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 5000 | uM | 10996.143 | 0.6140 | -0.5992 | 0.3034 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 200 | uM | 10996.143 | 0.9440 | 0.6543 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Ibandronate | FDPS | 1500 | uM | 10996.143 | 0.4821 | -0.8193 | 0.3034 | ||
| HCC2185 | TNBC | Luminal | Ibandronate | FDPS | 300 | uM | 10996.143 | 0.4931 | -0.8055 | 0.3034 | ||
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 1.6 | uM | 10996.143 | 0.9665 | 0.7873 | 0.3034 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 8 | uM | 10996.143 | 0.9658 | 0.7835 | 0.3034 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 0.32 | uM | 10996.143 | 0.9844 | 0.8991 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Ibandronate | FDPS | 60 | uM | 10996.143 | 0.6571 | -0.4988 | 0.3034 | ||
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 40 | uM | 10996.143 | 0.9331 | 0.5917 | 0.3034 |