Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 33.3 | uM | 10874.152 | 0.0173 | -0.9896 | 0.7706 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.0533 | uM | 12220.159 | 1.0078 | 1.0329 | 0.4788 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.000427 | uM | 12220.159 | 0.9609 | 0.8401 | 0.4788 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.0107 | uM | 12220.159 | 1.0334 | 1.1422 | 0.4788 | |
| MX1 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 0.000427 | uM | 7523.069 | 0.9743 | 0.9465 | 0.9585 | |
| MX1 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 0.0000853 | uM | 7523.069 | 0.9197 | 0.8327 | 0.9585 | |
| MX1 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 0.00213 | uM | 7523.069 | 0.8722 | 0.7341 | 0.9585 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.00213 | uM | 12220.159 | 1.0000 | 1.0000 | 0.4788 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12220.159 | 0.1742 | -0.9480 | 0.4788 | |
| MX1 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 0.0533 | uM | 7523.069 | 0.8041 | 0.5930 | 0.9585 | |
| T47DKBLUC | Unknown | Unknown | Ribavirin | 50 | uM | 15360.211 | 0.8760 | 0.7199 | 0.8772 | |||
| HBL-100 | Unknown | Unknown | Taxol | TUBB | TUBB | 0.00213 | uM | 7808.002 | 0.7604 | 0.7782 | 2.3302 | |
| MX1 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 0.267 | uM | 7523.069 | 0.7679 | 0.5183 | 0.9585 | |
| T47DKBLUC | Unknown | Unknown | Ribavirin | 2 | uM | 15360.211 | 1.0122 | 1.0278 | 0.8772 | |||
| T47DKBLUC | Unknown | Unknown | Ribavirin | 0.08 | uM | 15360.211 | 1.0969 | 1.2224 | 0.8772 | |||
| T47DKBLUC | Unknown | Unknown | Ribavirin | 0.00064 | uM | 15360.211 | 0.9839 | 0.9633 | 0.8772 | |||
| HBL-100 | Unknown | Unknown | Taxol | TUBB | TUBB | 0.00213 | uM | 7807.002 | 0.8015 | 0.8058 | 2.1668 | |
| T47DKBLUC | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 33.3 | uM | 12608.152 | 0.4765 | 0.0484 | 1.1477 | |
| T47DKBLUC | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 6.67 | uM | 12608.152 | 0.4594 | 0.0155 | 1.1477 | |
| T47DKBLUC | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 1.33 | uM | 12608.152 | 0.9932 | 0.9881 | 1.1477 | |
| T47DKBLUC | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.267 | uM | 12608.152 | 1.0253 | 1.0441 | 1.1477 | |
| MX1 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 1.33 | uM | 7523.069 | 0.7929 | 0.5698 | 0.9585 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 0.267 | uM | 10644.14 | 0.3409 | -0.8361 | 0.4302 | |
| MB 157 | Unknown | Unknown | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 40 | uM | 7482.084 | 1.3131 | 1.3136 | 1.8697 | |
| MB 157 | Unknown | Unknown | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 8 | uM | 7482.084 | 1.2086 | 1.2133 | 1.8697 |