Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Dichloroacetate | PDK | PDK | 0.0000427 | uM | 13091.176 | 0.9938 | 0.9859 | 0.8746 | |
| 600MPE | HR+ | Luminal | Dichloroacetate | PDK | PDK | 0.00533 | uM | 13091.176 | 0.9734 | 0.9393 | 0.8746 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 5898.091 | 1.0111 | 1.0362 | 0.6159 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 5898.091 | 1.0031 | 1.0100 | 0.6159 | |
| 600MPE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 6.67 | uM | 5898.086 | 0.1648 | -0.9057 | 0.5904 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 5898.091 | 0.9553 | 0.8570 | 0.6159 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.533 | uM | 5899.07 | 0.6294 | 0.1852 | 0.8850 | |
| 600MPE | HR+ | Luminal | Dichloroacetate | PDK | PDK | 0.0267 | uM | 13091.176 | 0.9505 | 0.8872 | 0.8746 | |
| 600MPE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 1.33 | uM | 5898.086 | 0.2367 | -0.8258 | 0.5904 | |
| 600MPE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 33.3 | uM | 5898.086 | 0.1504 | -0.9192 | 0.5904 | |
| 600MPE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 5898.086 | 1.0013 | 1.0044 | 0.5904 | |
| 600MPE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.000427 | uM | 5898.086 | 0.9242 | 0.7500 | 0.5904 | |
| 600MPE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.00213 | uM | 5898.086 | 0.8719 | 0.5855 | 0.5904 | |
| 600MPE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0107 | uM | 5898.086 | 0.8226 | 0.4369 | 0.5904 | |
| 600MPE | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0533 | uM | 5898.086 | 0.6133 | -0.1264 | 0.5904 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.904 | uM | 5899.09 | 1.0299 | 1.0574 | 1.0401 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 4.52 | uM | 5899.09 | 1.0156 | 1.0299 | 1.0401 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.0362 | uM | 5899.09 | 0.9718 | 0.9458 | 1.0401 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.181 | uM | 5899.09 | 1.0203 | 1.0391 | 1.0401 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 22.6 | uM | 5899.09 | 0.7913 | 0.5969 | 1.0401 | |
| 600MPE | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 26.7 | uM | 12224.147 | 0.2741 | -0.5543 | 0.8621 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 2.67 | uM | 5899.07 | 0.3140 | -0.4598 | 0.8850 | |
| 600MPE | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 133 | uM | 12224.147 | 0.1143 | -0.8385 | 0.8621 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.00723 | uM | 5899.09 | 0.9629 | 0.9286 | 1.0401 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 113 | uM | 5899.09 | 0.0093 | -0.9778 | 1.0401 |