Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.00427 | uM | 14849.203 | 1.0138 | 1.0347 | 0.7976 | |
| T47DKBLUC | Unknown | Unknown | Omipalisib | PI3K | PI3K | 1.33 | uM | 7544.087 | 0.4199 | -0.0464 | 1.1715 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.00427 | uM | 14849.203 | 1.0138 | 1.0347 | 0.7976 | |
| T47DKBLUC | Unknown | Unknown | Omipalisib | PI3K | PI3K | 0.0533 | uM | 7544.087 | 0.5716 | 0.2407 | 1.1715 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.0213 | uM | 14849.203 | 0.5604 | -0.0323 | 0.7976 | |
| T47DKBLUC | Unknown | Unknown | Omipalisib | PI3K | PI3K | 0.267 | uM | 7544.087 | 0.4018 | -0.0817 | 1.1715 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.0213 | uM | 14849.203 | 0.5604 | -0.0323 | 0.7976 | |
| T47DKBLUC | Unknown | Unknown | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7545.087 | 1.0119 | 1.0210 | 1.1323 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 66.7 | uM | 14849.203 | 0.0169 | -0.9880 | 0.7976 | |
| T47DKBLUC | Unknown | Unknown | Omipalisib | PI3K | PI3K | 6.67 | uM | 7544.087 | 0.3477 | -0.1883 | 1.1715 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.533 | uM | 14849.203 | 0.0176 | -0.9874 | 0.7976 | |
| T47DKBLUC | Unknown | Unknown | Omipalisib | PI3K | PI3K | 33.3 | uM | 7544.087 | 0.2963 | -0.2919 | 1.1715 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 13.3 | uM | 14849.203 | 0.0147 | -0.9900 | 0.7976 | |
| T47DKBLUC | Unknown | Unknown | Omipalisib | PI3K | PI3K | 6.67 | uM | 7545.087 | 0.2791 | -0.3521 | 1.1323 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 2.67 | uM | 14849.203 | 0.0127 | -0.9916 | 0.7976 | |
| T47DKBLUC | Unknown | Unknown | Omipalisib | PI3K | PI3K | 0.267 | uM | 7545.087 | 0.3306 | -0.2475 | 1.1323 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.533 | uM | 14849.203 | 0.0176 | -0.9874 | 0.7976 | |
| T47DKBLUC | Unknown | Unknown | Omipalisib | PI3K | PI3K | 1.33 | uM | 7545.087 | 0.2897 | -0.3304 | 1.1323 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 2.67 | uM | 14849.203 | 0.0127 | -0.9916 | 0.7976 | |
| T47DKBLUC | Unknown | Unknown | Omipalisib | PI3K | PI3K | 33.3 | uM | 7545.087 | 0.1860 | -0.5472 | 1.1323 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 66.7 | uM | 14849.203 | 0.0169 | -0.9880 | 0.7976 | |
| MB 157 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 0.00427 | uM | 7482.066 | 1.0489 | 1.0859 | 1.1347 | |
| T47DKBLUC | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 13.3 | uM | 14849.203 | 0.0147 | -0.9900 | 0.7976 | |
| HBL-100 | Unknown | Unknown | Oxaliplatin | DNA cross-linker | DNA cross-linker | 25.2 | uM | 9226.021 | 0.1398 | -0.0854 | 2.5142 | |
| HMT-3522 S1 | Unknown | Unknown | CGC-11047 | Polyamine analogue | 5000 | uM | 7911.018 | 0.0170 | -0.7780 | 1.8543 |