Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 7794.018 | 1.4132 | 1.4568 | 1.6812 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.685 | uM | 7794.018 | 1.2711 | 1.3067 | 1.6812 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 0.0011 | uM | 7429.102 | 1.0177 | 1.0145 | 2.4347 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.000219 | uM | 9035.018 | 1.0664 | 1.0606 | 2.1555 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00548 | uM | 7794.018 | 1.4272 | 1.4713 | 1.6812 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.0274 | uM | 7794.018 | 1.4325 | 1.4767 | 1.6812 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9035.018 | 1.0285 | 1.0263 | 2.1555 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00548 | uM | 9035.018 | 0.9995 | 0.9995 | 2.1555 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 9035.018 | 0.9639 | 0.9662 | 2.1555 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.0000438 | uM | 9035.018 | 0.9559 | 0.9586 | 2.1555 | |
| 184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 0.0000438 | uM | 7787.018 | 0.9220 | 0.6145 | 0.3791 | |
| 184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 0.0274 | uM | 7787.018 | 1.0819 | 1.4617 | 0.3791 | |
| 184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 0.0011 | uM | 9047.026 | 0.9268 | 0.7610 | 0.5972 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 9146.122 | 1.0961 | 1.1417 | 1.3408 | |
| 184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 0.137 | uM | 7787.018 | 0.8892 | 0.4671 | 0.3791 | |
| MDA-MB-157 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.0000438 | uM | 7879.018 | 0.9920 | 0.9911 | 1.7910 | |
| 184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 0.0000438 | uM | 9047.026 | 0.8904 | 0.6465 | 0.5972 | |
| T47D | HR+ | Luminal | Cetuximab | EGFR | ErbB | 0.0000438 | uM | 9033.018 | 1.0820 | 1.1895 | 0.8708 | |
| 184B5 | NM | Basal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9095.026 | 1.2784 | 1.5465 | 1.0168 | |
| 184B5 | NM | Basal | Cetuximab | EGFR | ErbB | 0.00548 | uM | 9095.026 | 0.9080 | 0.8188 | 1.0168 | |
| MDA-MB-157 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 0.00000877 | uM | 7879.018 | 1.0317 | 1.0352 | 1.7910 | |
| 184B5 | NM | Basal | Cetuximab | EGFR | ErbB | 0.137 | uM | 9095.026 | 0.6716 | 0.3521 | 1.0168 | |
| 184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 0.685 | uM | 9047.026 | 0.5521 | -0.2605 | 0.5972 | |
| 184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 0.00000175 | uM | 9047.026 | 0.9014 | 0.6810 | 0.5972 | |
| 184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 0.0274 | uM | 9047.026 | 0.6827 | 0.0555 | 0.5972 |