Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Nilotinib | ABL | nRTK | 0.32 | uM | 11854.145 | 1.0456 | 1.0785 | 1.1581 | |
| BT-20 | TNBC | Basal A | Nilotinib | ABL | nRTK | 1.6 | uM | 11854.145 | 1.1054 | 1.1808 | 1.1581 | |
| BT-20 | TNBC | Basal A | Nilotinib | ABL | nRTK | 40 | uM | 11854.145 | 0.6955 | 0.4616 | 1.1581 | |
| BT-20 | TNBC | Basal A | Nilotinib | ABL | nRTK | 200 | uM | 11854.145 | 0.7926 | 0.6363 | 1.1581 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 0.064 | uM | 12056.145 | 0.9640 | 0.9143 | 0.8365 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 0.32 | uM | 12056.145 | 0.9884 | 0.9724 | 0.8365 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 8 | uM | 12056.145 | 0.9102 | 0.7873 | 0.8365 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 40 | uM | 12056.145 | 0.9807 | 0.9538 | 0.8365 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 0.00256 | uM | 12178.145 | 0.9880 | 0.9611 | 0.6127 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 0.0128 | uM | 12178.145 | 1.0142 | 1.0466 | 0.6127 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 0.32 | uM | 12178.145 | 0.9214 | 0.7499 | 0.6127 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 1.6 | uM | 12178.145 | 1.0524 | 1.1739 | 0.6127 | |
| 184A1 | NM | Basal | Nilotinib | ABL | nRTK | 0.000512 | uM | 12509.17 | 1.0051 | 1.0074 | 1.3955 | |
| 184A1 | NM | Basal | Nilotinib | ABL | nRTK | 0.00256 | uM | 12509.17 | 1.0256 | 1.0365 | 1.3955 | |
| 184A1 | NM | Basal | Nilotinib | ABL | nRTK | 0.064 | uM | 12509.17 | 0.9781 | 0.9686 | 1.3955 | |
| 184A1 | NM | Basal | Nilotinib | ABL | nRTK | 0.32 | uM | 12509.17 | 0.9479 | 0.9248 | 1.3955 | |
| 184A1 | NM | Basal | Nilotinib | ABL | nRTK | 40 | uM | 12509.17 | 0.8807 | 0.8260 | 1.3955 | |
| 184A1 | NM | Basal | Nilotinib | ABL | nRTK | 200 | uM | 12509.17 | 0.9381 | 0.9104 | 1.3955 | |
| 184B5 | NM | Basal | Nilotinib | ABL | nRTK | 0.00256 | uM | 12566.17 | 0.9796 | 0.9720 | 1.4648 | |
| 184B5 | NM | Basal | Nilotinib | ABL | nRTK | 0.0128 | uM | 12566.17 | 0.9920 | 0.9890 | 1.4648 | |
| 184B5 | NM | Basal | Nilotinib | ABL | nRTK | 8 | uM | 12566.17 | 0.9553 | 0.9386 | 1.4648 | |
| 184B5 | NM | Basal | Nilotinib | ABL | nRTK | 40 | uM | 12566.17 | 0.9504 | 0.9318 | 1.4648 | |
| 600MPE | HR+ | Luminal | Nilotinib | ABL | nRTK | 0.000512 | uM | 12224.145 | 1.0393 | 1.0807 | 0.9737 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 0.0128 | uM | 12291.17 | 0.9824 | 0.9373 | 0.5585 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 0.00256 | uM | 12291.17 | 0.9868 | 0.9531 | 0.5585 |