Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HMT-3522 S1 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 86.2 | uM | 10124.034 | 0.0040 | -0.8261 | 2.2594 | |
| HMT-3522 T4-2 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 86.2 | uM | 10147.034 | 0.0012 | -0.8841 | 2.3470 | |
| MDA-MB-468 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7906.007 | 0.0772 | -0.9680 | 0.6194 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 9421.034 | 0.0089 | -0.9990 | 0.6220 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7849.043 | 0.3670 | -0.8857 | 0.3502 | |
| HCC1428 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 10031.034 | 0.0174 | -0.9868 | 0.8064 | |
| MDA-MB-468 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7907.043 | 0.9918 | 0.9899 | 1.6330 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 10263.034 | 0.0057 | -1.0000 | 0.3750 | |
| HCC1143 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7810.007 | 0.0267 | -0.9538 | 0.9616 | |
| SUM1315MO2 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 86.2 | uM | 10139.034 | 0.0883 | -0.8895 | 0.8381 | |
| HCC1954 | HER2amp | Basal A | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7837.007 | 0.0055 | -0.9154 | 1.6436 | |
| Hs 578T | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 86.2 | uM | 9511.034 | 0.0083 | -0.9726 | 1.1177 | |
| SUM159PT | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7918.007 | 0.0042 | -0.6820 | 2.9756 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7849.007 | 0.5203 | -0.5541 | 0.4353 | |
| HCC3153 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7853.007 | 0.1179 | -0.5967 | 1.3351 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7875.007 | 0.0336 | -0.7945 | 1.4906 | |
| MDA-MB-361 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 10095.034 | 0.0078 | -0.9958 | 0.7874 | |
| HCC1937 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 86.2 | uM | 10262.034 | 0.1736 | -0.8572 | 0.6634 | |
| HCC3153 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 86.2 | uM | 10056.034 | 0.0971 | -0.8651 | 0.8648 | |
| UACC-812 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 10150.034 | 0.0118 | -1.0000 | 0.3592 | |
| MCF7 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 10073.034 | 0.1471 | -0.9375 | 0.5531 | |
| MCF 10A | NM | Basal B | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7870.007 | 0.0041 | -0.8598 | 2.0710 | |
| BT-474 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 9157.034 | 0.0065 | -0.9828 | 1.0593 | |
| HCC1569 | HER2amp | Basal A | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7825.007 | 0.3419 | -0.0130 | 1.5199 | |
| MDA-MB-415 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 86.2 | uM | 7897.007 | 0.0004 | -0.9997 | 0.8772 |