Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 11852.155 | 0.9883 | 0.9846 | 1.5196 | |
| HCC3153 | TNBC | Basal A | Nelfinavir | 0.0000853 | uM | 13583.174 | 1.0655 | 1.3793 | 0.3654 | |||
| LY2 | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10816.155 | 1.0550 | 1.1323 | 0.8353 | |
| HCC3153 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10937.151 | 0.9588 | 0.9455 | 1.5219 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 0.0000853 | uM | 7455.092 | 1.2037 | 1.2363 | 1.6605 | |
| 184B5 | NM | Basal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12566.165 | 0.9718 | 0.9671 | 1.7248 | |
| HCC1937 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10262.001 | 1.0198 | 1.0653 | 0.6105 | |
| HCC2185 | TNBC | Luminal | Erlotinib | EGFR | ErbB | 0.0000853 | uM | 7462.092 | 1.0236 | 1.1107 | 0.4336 | |
| UACC-812 | HER2amp | Luminal | PD184352 | MEK | MAPK | 0.0000853 | uM | 11938.155 | 0.9076 | 0.7379 | 0.6903 | |
| MDA-MB-134-VI | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 10519.087 | 0.9690 | 0.9396 | 1.0259 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10872.153 | 0.9602 | 0.9485 | 1.5576 | |
| HCC3153 | TNBC | Basal A | Nelfinavir | 0.0000853 | uM | 13733.174 | 0.9495 | 0.8064 | 0.5093 | |||
| MDA-MB-157 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7496.087 | 1.0194 | 1.0383 | 1.0123 | |
| MCF 10F | NM | - | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7486.087 | 1.0418 | 1.0695 | 1.1994 | |
| MCF 10F | NM | - | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12254.165 | 0.9933 | 0.9921 | 1.6980 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9648.001 | 1.0008 | 1.0025 | 0.6289 | |
| MCF12A | NM | Basal B | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7490.086 | 0.9665 | 0.9728 | 2.4876 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10095.001 | 0.9493 | 0.8883 | 0.9049 | |
| MCF7 | HR+ | Luminal | Omipalisib | PI3K | PI3K | 0.0000853 | uM | 7493.086 | 1.0202 | 1.0451 | 0.8986 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10693.153 | 1.0057 | 1.0141 | 0.8137 | |
| MCF12A | NM | Basal B | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10817.153 | 1.0360 | 1.0427 | 1.6726 | |
| HCC38 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10578.139 | 0.9445 | 0.9317 | 1.6434 | |
| T47D | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7543.066 | 0.9808 | 0.9742 | 1.4960 | |
| MDA-MB-361 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 10472.066 | 1.0215 | 1.0584 | 0.7390 | |
| HCC38 | TNBC | Basal B | Nelfinavir | 0.0000853 | uM | 12617.174 | 0.9955 | 0.9944 | 1.5935 |