Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7894.001 | 1.0574 | 1.1509 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | Nelfinavir | 0.0000853 | uM | 13558.174 | 0.9788 | 0.9262 | 0.5699 | |||
| MDA-MB-231 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7892.016 | 0.9996 | 0.9997 | 2.3475 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7898.001 | 1.1222 | 1.1959 | 1.2337 | |
| ZR75B | HR+ | Luminal | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 11939.155 | 0.9469 | 0.9355 | 1.6625 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9972.019 | 1.0125 | 1.0235 | 1.0654 | |
| ZR75B | HR+ | Luminal | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9997.024 | 1.1073 | 1.2216 | 0.9704 | |
| SUM149PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7530.066 | 1.1131 | 1.1117 | 1.9710 | |
| HCC3153 | TNBC | Basal A | Nelfinavir | 0.0000853 | uM | 12939.174 | 0.9946 | 0.9692 | 0.3466 | |||
| SUM102PT | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 9777.049 | 0.9919 | 0.9742 | 0.6254 | |
| HCC3153 | TNBC | Basal A | Nelfinavir | 0.0000853 | uM | 13583.174 | 1.0655 | 1.3793 | 0.3654 | |||
| HCC1187 | TNBC | Basal A | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7433.066 | 1.0530 | 1.0984 | 1.0755 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7902.001 | 1.2182 | 1.2146 | 1.9359 | |
| MX1 | Unknown | Unknown | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7523.066 | 0.9672 | 0.9196 | 0.8127 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9889.001 | 0.9863 | 0.9813 | 1.4638 | |
| MDA-MB-361 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7506.088 | 1.0157 | 1.0300 | 1.0417 | |
| MDA-MB-231 | TNBC | Basal B | Gefitinib | EGFR | ErbB | 0.0000853 | uM | 7893.016 | 1.0184 | 1.0166 | 2.2064 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7900.001 | 1.3847 | 2.0128 | 0.7944 | |
| MDA-MB-436 | TNBC | Basal B | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7899.001 | 1.1127 | 1.1073 | 2.0444 | |
| HCC1187 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10753.146 | 0.9625 | 0.9479 | 1.4503 | |
| MDA-MB-453 | TNBC | Luminal | GW-5074 | CRAF | MAPK | 0.0000853 | uM | 7517.088 | 1.0193 | 1.0263 | 1.4687 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7863.001 | 1.0188 | 1.0214 | 1.7540 | |
| SUM159PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7531.066 | 1.0351 | 1.0209 | 3.3129 | |
| HCC202 | HER2amp | Luminal | Nelfinavir | 0.0000853 | uM | 13135.174 | 0.9482 | 0.8074 | 0.5256 | |||
| HCC3153 | TNBC | Basal A | Nelfinavir | 0.0000853 | uM | 13733.174 | 0.9495 | 0.8064 | 0.5093 |